Staff View: The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)

The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)

Background: International guidelines recommend the use of indirect calorimetry (IC) to measure energy requirements in critically ill patients. This study aimed to assess the effects of IC-guided nutrition vs standard-nutrition care on clinical outcomes in critically ill patients. Methods: Sixty m...

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Main Authors:	Mat Nor, Mohd Basri, Samiullah, Saeed, Md Ralib, Azrina, Mohamad Aidid, Edre
Format:	Conference or Workshop Item
Language:	English
Published:	IIUM Press 2021
Subjects:	RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Online Access:	http://irep.iium.edu.my/91493/1/91493_The%20Impact%20Of%20Indirect%20Calorimetry%20Guided%20Feeding%20Protocol.pdf http://irep.iium.edu.my/91493/ https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/583
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spelling	my.iium.irep.914932021-08-20T10:16:44Z http://irep.iium.edu.my/91493/ The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study) Mat Nor, Mohd Basri Samiullah, Saeed Md Ralib, Azrina Mohamad Aidid, Edre RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid Background: International guidelines recommend the use of indirect calorimetry (IC) to measure energy requirements in critically ill patients. This study aimed to assess the effects of IC-guided nutrition vs standard-nutrition care on clinical outcomes in critically ill patients. Methods: Sixty mechanically ventilated patients expected to stay in intensive care unit (ICU) more than 3 days were randomized into a group in which energy needs were determined by IC (IC-group) and a group prescribed with 25kcal/kg/day reflecting standard care (SC-group). The primary outcome was the ICU length of stay(LOS). Secondary outcomes included change in quadriceps muscle layer thickness (QMLT, ultrasound) during the first 10 days of ICU admission, hospital-LOS, duration of mechanical ventilation, ICU mortality and 28-day-in hospital mortality. Results: Mean energy requirement was similar in both groups. The IC group received 85.63%, whereas the SC group received 76.83% of their energy goals (P=0.002). The protein intake was higher in the IC group (89.58% vs 77.66%, p=0.007). Both groups had a median of 8.0 days ICU-LOS (p=0.424). QMLT was decreased in both groups by 21.9% vs. 25.3% at day10 (p < 0.001), respectively. However, there were no significant differences observed in muscle mass changes and other secondary clinical outcomes between the groups. Conclusion: IC-guided nutrition did not appear to affect significantly any clinical outcomes compared to the SC group due to the limitation in Sample size. Clinicaltrials.gov identifier no. NCT04479254 IIUM Press 2021-04-08 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/91493/1/91493_The%20Impact%20Of%20Indirect%20Calorimetry%20Guided%20Feeding%20Protocol.pdf Mat Nor, Mohd Basri and Samiullah, Saeed and Md Ralib, Azrina and Mohamad Aidid, Edre (2021) The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study). In: Kuantan Research Day 2020: A National Online Event for E-poster Presentation, Kuantan, Pahang. https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/583
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
spellingShingle	RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid Mat Nor, Mohd Basri Samiullah, Saeed Md Ralib, Azrina Mohamad Aidid, Edre The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)
description	Background: International guidelines recommend the use of indirect calorimetry (IC) to measure energy requirements in critically ill patients. This study aimed to assess the effects of IC-guided nutrition vs standard-nutrition care on clinical outcomes in critically ill patients. Methods: Sixty mechanically ventilated patients expected to stay in intensive care unit (ICU) more than 3 days were randomized into a group in which energy needs were determined by IC (IC-group) and a group prescribed with 25kcal/kg/day reflecting standard care (SC-group). The primary outcome was the ICU length of stay(LOS). Secondary outcomes included change in quadriceps muscle layer thickness (QMLT, ultrasound) during the first 10 days of ICU admission, hospital-LOS, duration of mechanical ventilation, ICU mortality and 28-day-in hospital mortality. Results: Mean energy requirement was similar in both groups. The IC group received 85.63%, whereas the SC group received 76.83% of their energy goals (P=0.002). The protein intake was higher in the IC group (89.58% vs 77.66%, p=0.007). Both groups had a median of 8.0 days ICU-LOS (p=0.424). QMLT was decreased in both groups by 21.9% vs. 25.3% at day10 (p < 0.001), respectively. However, there were no significant differences observed in muscle mass changes and other secondary clinical outcomes between the groups. Conclusion: IC-guided nutrition did not appear to affect significantly any clinical outcomes compared to the SC group due to the limitation in Sample size. Clinicaltrials.gov identifier no. NCT04479254
format	Conference or Workshop Item
author	Mat Nor, Mohd Basri Samiullah, Saeed Md Ralib, Azrina Mohamad Aidid, Edre
author_facet	Mat Nor, Mohd Basri Samiullah, Saeed Md Ralib, Azrina Mohamad Aidid, Edre
author_sort	Mat Nor, Mohd Basri
title	The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)
title_short	The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)
title_full	The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)
title_fullStr	The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)
title_full_unstemmed	The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)
title_sort	impact of indirect calorimetry guided feeding protocol on clinical outcomes in critically ill patients: a randomized controlled trial (the ic study)
publisher	IIUM Press
publishDate	2021
url	http://irep.iium.edu.my/91493/1/91493_The%20Impact%20Of%20Indirect%20Calorimetry%20Guided%20Feeding%20Protocol.pdf http://irep.iium.edu.my/91493/ https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/583
_version_	1709667155432177664
score	13.211869

The Impact Of Indirect Calorimetry Guided Feeding Protocol On Clinical Outcomes In Critically Ill Patients: A Randomized Controlled Trial (The Ic Study)

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