The effects of Tualang honey on sperm profile In mixed cholesterol diet administered rats
Introduction: Hypercholesterolaemia is a recognised factor associated with male infertility. They have been shown to reduce the semen quality. The main recommendation for treatment is diet modifications. Tualang honey (TH) has proven to exert anti-inflammatory and anti-oxidative effects which may he...
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my.iium.irep.914742022-04-07T01:52:54Z http://irep.iium.edu.my/91474/ The effects of Tualang honey on sperm profile In mixed cholesterol diet administered rats Hasan, Sakiinah Abdul Rahim, Roslina Alias, Mohd Afzal Muhammad, Siti Aeshah @ Naznin Abdullah, Nor Zamzila Abdul Razak, Redzuan Nul Hakim QP Physiology R Medicine (General) RB Pathology RC620 Specialties of Internal Medicine-Nutritional Diseases RC627 Specialties of Internal Medicine-Metabolic Diseases RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents RM214 Diet therapy. Diet and dietectics in disease RZ Other systems of medicine Introduction: Hypercholesterolaemia is a recognised factor associated with male infertility. They have been shown to reduce the semen quality. The main recommendation for treatment is diet modifications. Tualang honey (TH) has proven to exert anti-inflammatory and anti-oxidative effects which may help to improve sperm parameters. Methods: Thirty male Sprague Dawley rats were divided into two groups, mixed cholesterol diet (12%CD;n=24) and standard diet (SD;n=6) and were fed for 16 weeks. Then, the rats in the 12%CD group were divided into four groups and continued with SD. Group A was untreated while group B, C and D were given TH at different doses (1.2, 2.4, and 3.0g/kg/day) for 4 weeks. Then, sperm profile analysis from the caudal epididymis was performed. Results: Group A showed significant decrease in sperm concentration, the percentage of total sperm motility, progressive motility, and viability compared to SD group (p<0.001). In contrast, all TH supplemented groups demonstrated significant improvement in the sperm parameters (p<0.001). The higher the dosage of TH given, the higher the improvements in sperm parameters (p<0.001). Conclusion: TH supplementation with diet modifications improved sperm profile parameters. From our findings, there is a need to further explore TH in improving male infertility associated with hypercholesterolaemia. 2021-03-29 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/91474/1/YSM-ASM%20ISVC%202021%20poster.pdf application/pdf en http://irep.iium.edu.my/91474/2/E-cert%20YSN-ASM%20ISVC%20Poster%20Presenter-36.pdf application/pdf en http://irep.iium.edu.my/91474/3/ISVC2021%20Poster%20Acceptance%20Letter_Sakiinah%20binti%20Hasan.pdf application/pdf en http://irep.iium.edu.my/91474/4/SAKIINAHHASAN_YSN-ASM%20Abstract%20.pdf Hasan, Sakiinah and Abdul Rahim, Roslina and Alias, Mohd Afzal and Muhammad, Siti Aeshah @ Naznin and Abdullah, Nor Zamzila and Abdul Razak, Redzuan Nul Hakim (2021) The effects of Tualang honey on sperm profile In mixed cholesterol diet administered rats. In: YSN-ASM International Scientific Virtual Conference (ISVC) 2021, 29th March 2021 - 1st April 2021, Kuala Lumpur, Malaysia. (Unpublished) |
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QP Physiology R Medicine (General) RB Pathology RC620 Specialties of Internal Medicine-Nutritional Diseases RC627 Specialties of Internal Medicine-Metabolic Diseases RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents RM214 Diet therapy. Diet and dietectics in disease RZ Other systems of medicine |
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QP Physiology R Medicine (General) RB Pathology RC620 Specialties of Internal Medicine-Nutritional Diseases RC627 Specialties of Internal Medicine-Metabolic Diseases RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents RM214 Diet therapy. Diet and dietectics in disease RZ Other systems of medicine Hasan, Sakiinah Abdul Rahim, Roslina Alias, Mohd Afzal Muhammad, Siti Aeshah @ Naznin Abdullah, Nor Zamzila Abdul Razak, Redzuan Nul Hakim The effects of Tualang honey on sperm profile In mixed cholesterol diet administered rats |
| description |
Introduction: Hypercholesterolaemia is a recognised factor associated with male infertility. They have been shown to reduce the semen quality. The main recommendation for treatment is diet modifications. Tualang honey (TH) has proven to exert anti-inflammatory and anti-oxidative effects which may help to improve sperm parameters.
Methods: Thirty male Sprague Dawley rats were divided into two groups, mixed cholesterol diet (12%CD;n=24) and standard diet (SD;n=6) and were fed for 16 weeks. Then, the rats in the 12%CD group were divided into four groups and continued with SD. Group A was untreated while group B, C and D were given TH at different doses (1.2, 2.4, and 3.0g/kg/day) for 4 weeks. Then, sperm profile analysis from the caudal epididymis was performed.
Results: Group A showed significant decrease in sperm concentration, the percentage of total sperm motility, progressive motility, and viability compared to SD group (p<0.001). In contrast, all TH supplemented groups demonstrated significant improvement in the sperm parameters (p<0.001). The higher the dosage of TH given, the higher the improvements in sperm parameters (p<0.001).
Conclusion: TH supplementation with diet modifications improved sperm profile parameters. From our findings, there is a need to further explore TH in improving male infertility associated with hypercholesterolaemia. |
| format |
Conference or Workshop Item |
| author |
Hasan, Sakiinah Abdul Rahim, Roslina Alias, Mohd Afzal Muhammad, Siti Aeshah @ Naznin Abdullah, Nor Zamzila Abdul Razak, Redzuan Nul Hakim |
| author_facet |
Hasan, Sakiinah Abdul Rahim, Roslina Alias, Mohd Afzal Muhammad, Siti Aeshah @ Naznin Abdullah, Nor Zamzila Abdul Razak, Redzuan Nul Hakim |
| author_sort |
Hasan, Sakiinah |
| title |
The effects of Tualang honey on sperm profile In mixed cholesterol diet administered rats |
| title_short |
The effects of Tualang honey on sperm profile In mixed cholesterol diet administered rats |
| title_full |
The effects of Tualang honey on sperm profile In mixed cholesterol diet administered rats |
| title_fullStr |
The effects of Tualang honey on sperm profile In mixed cholesterol diet administered rats |
| title_full_unstemmed |
The effects of Tualang honey on sperm profile In mixed cholesterol diet administered rats |
| title_sort |
effects of tualang honey on sperm profile in mixed cholesterol diet administered rats |
| publishDate |
2021 |
| url |
http://irep.iium.edu.my/91474/1/YSM-ASM%20ISVC%202021%20poster.pdf http://irep.iium.edu.my/91474/2/E-cert%20YSN-ASM%20ISVC%20Poster%20Presenter-36.pdf http://irep.iium.edu.my/91474/3/ISVC2021%20Poster%20Acceptance%20Letter_Sakiinah%20binti%20Hasan.pdf http://irep.iium.edu.my/91474/4/SAKIINAHHASAN_YSN-ASM%20Abstract%20.pdf http://irep.iium.edu.my/91474/ |
| _version_ |
1729702907057537024 |
| score |
13.211869 |