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Anticancer, antioxidant, and antibacterial activities of the methanolic extract from Sphagneticola trilobata (L.) J. F Pruski leaves

This study aims to investigate the potential of bioactive secondary metabolites contained in Sphagneticola trilobata (L.) J.F Pruski leaves as novel plant-derived anticancer agent. Qualitative bioactive compound contents in the methanolic extract of S. trilobata leaves were screened using phytochemi...

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Main Authors: Mardina, Vivi, Ilyas, Syafruddin, Halimatussakdiah,, Halimatussakdiah, Harmawan, Tisna, Tanjung, Masitta, Yusof, Faridah
Format: Article
Language:English
Published: National Library of Medicine 2021
Subjects:
Q Science (General)
TP248.13 Biotechnology
Online Access:http://irep.iium.edu.my/91438/6/91438_Anticancer%2C%20Antioxidant%2C%20and%20Antibacterial%20Activities.pdf
http://irep.iium.edu.my/91438/
https://pubmed.ncbi.nlm.nih.gov/34345598/
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spelling my.iium.irep.914382021-08-12T00:25:49Z http://irep.iium.edu.my/91438/ Anticancer, antioxidant, and antibacterial activities of the methanolic extract from Sphagneticola trilobata (L.) J. F Pruski leaves Mardina, Vivi Ilyas, Syafruddin Halimatussakdiah,, Halimatussakdiah Harmawan, Tisna Tanjung, Masitta Yusof, Faridah Q Science (General) TP248.13 Biotechnology This study aims to investigate the potential of bioactive secondary metabolites contained in Sphagneticola trilobata (L.) J.F Pruski leaves as novel plant-derived anticancer agent. Qualitative bioactive compound contents in the methanolic extract of S. trilobata leaves were screened using phytochemical method. Antioxidant evaluation was carried out using 2,2-diphenyl-1-picrylhydrazyl assay; antibacterial - using well diffusion method on Escherichia coli and Salmonella typhi; and cytotoxicity - using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay on MCF-7 cell line and Vero Cell. It was found that the methanolic extract exhibited antioxidant activity with an IC50 value of 124.34 μg/mL. The inhibition zone values against E. coli and S. thypi (at extract concentration of 100 mg/mL) were 34.33 and 36 mm, respectively. In vitro MTT assay showed that our extract successfully reached 96% mortality with LC50 = 189.287 μg/mL, where the selective index of 2.5 suggest its selectivity against MCF-7 breast cancer cell line. In conclusion, the data of biological activities suggest the potential development of methanolic extract from S. trilobata leaves as a phytomedicine for breast cancer treatment. National Library of Medicine 2021-07-16 Article PeerReviewed application/pdf en http://irep.iium.edu.my/91438/6/91438_Anticancer%2C%20Antioxidant%2C%20and%20Antibacterial%20Activities.pdf Mardina, Vivi and Ilyas, Syafruddin and Halimatussakdiah,, Halimatussakdiah and Harmawan, Tisna and Tanjung, Masitta and Yusof, Faridah (2021) Anticancer, antioxidant, and antibacterial activities of the methanolic extract from Sphagneticola trilobata (L.) J. F Pruski leaves. J Adv Pharm Technol Res., 12 (3). pp. 222-226. E-ISSN 3434-5598 https://pubmed.ncbi.nlm.nih.gov/34345598/ 10.4103/japtr.JAPTR_131_21
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic Q Science (General)
TP248.13 Biotechnology
spellingShingle Q Science (General)
TP248.13 Biotechnology
Mardina, Vivi
Ilyas, Syafruddin
Halimatussakdiah,, Halimatussakdiah
Harmawan, Tisna
Tanjung, Masitta
Yusof, Faridah
Anticancer, antioxidant, and antibacterial activities of the methanolic extract from Sphagneticola trilobata (L.) J. F Pruski leaves
description This study aims to investigate the potential of bioactive secondary metabolites contained in Sphagneticola trilobata (L.) J.F Pruski leaves as novel plant-derived anticancer agent. Qualitative bioactive compound contents in the methanolic extract of S. trilobata leaves were screened using phytochemical method. Antioxidant evaluation was carried out using 2,2-diphenyl-1-picrylhydrazyl assay; antibacterial - using well diffusion method on Escherichia coli and Salmonella typhi; and cytotoxicity - using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay on MCF-7 cell line and Vero Cell. It was found that the methanolic extract exhibited antioxidant activity with an IC50 value of 124.34 μg/mL. The inhibition zone values against E. coli and S. thypi (at extract concentration of 100 mg/mL) were 34.33 and 36 mm, respectively. In vitro MTT assay showed that our extract successfully reached 96% mortality with LC50 = 189.287 μg/mL, where the selective index of 2.5 suggest its selectivity against MCF-7 breast cancer cell line. In conclusion, the data of biological activities suggest the potential development of methanolic extract from S. trilobata leaves as a phytomedicine for breast cancer treatment.
format Article
author Mardina, Vivi
Ilyas, Syafruddin
Halimatussakdiah,, Halimatussakdiah
Harmawan, Tisna
Tanjung, Masitta
Yusof, Faridah
author_facet Mardina, Vivi
Ilyas, Syafruddin
Halimatussakdiah,, Halimatussakdiah
Harmawan, Tisna
Tanjung, Masitta
Yusof, Faridah
author_sort Mardina, Vivi
title Anticancer, antioxidant, and antibacterial activities of the methanolic extract from Sphagneticola trilobata (L.) J. F Pruski leaves
title_short Anticancer, antioxidant, and antibacterial activities of the methanolic extract from Sphagneticola trilobata (L.) J. F Pruski leaves
title_full Anticancer, antioxidant, and antibacterial activities of the methanolic extract from Sphagneticola trilobata (L.) J. F Pruski leaves
title_fullStr Anticancer, antioxidant, and antibacterial activities of the methanolic extract from Sphagneticola trilobata (L.) J. F Pruski leaves
title_full_unstemmed Anticancer, antioxidant, and antibacterial activities of the methanolic extract from Sphagneticola trilobata (L.) J. F Pruski leaves
title_sort anticancer, antioxidant, and antibacterial activities of the methanolic extract from sphagneticola trilobata (l.) j. f pruski leaves
publisher National Library of Medicine
publishDate 2021
url http://irep.iium.edu.my/91438/6/91438_Anticancer%2C%20Antioxidant%2C%20and%20Antibacterial%20Activities.pdf
http://irep.iium.edu.my/91438/
https://pubmed.ncbi.nlm.nih.gov/34345598/
_version_ 1709667151448637440
score 13.211869

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