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Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies

Cancer-associated thrombosis (CAT) is a leading cause of death in cancer patients receiving outpatient chemotherapy. The latest guidelines emphasize stratifying the patients in terms of CAT risks periodically. Multiple risk assessment models (RAMs) were developed to classify patients and guide th...

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Main Authors:	Mosaad, Manar, Elnaem, Mohamed Hassan Abdelaziz, Cheema, Ejaz, Ibrahim, Ismail, Ab Rahman, Jamalludin, Kori, Ahlam Naila, How, Soon Hin
Format:	Article
Language:	English English
Published:	Dove Medical Press Ltd 2021
Subjects:	R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/91290/7/91290_Cancer-Associated%20Thrombosis_Scopus.pdf http://irep.iium.edu.my/91290/13/91290_Cancer-Associated%20Thrombosis.pdf http://irep.iium.edu.my/91290/
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spelling	my.iium.irep.912902022-07-15T02:13:29Z http://irep.iium.edu.my/91290/ Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies Mosaad, Manar Elnaem, Mohamed Hassan Abdelaziz Cheema, Ejaz Ibrahim, Ismail Ab Rahman, Jamalludin Kori, Ahlam Naila How, Soon Hin R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica Cancer-associated thrombosis (CAT) is a leading cause of death in cancer patients receiving outpatient chemotherapy. The latest guidelines emphasize stratifying the patients in terms of CAT risks periodically. Multiple risk assessment models (RAMs) were developed to classify patients and guide thromboprophylaxis to high-risk patients. This study aimed to discuss and highlight different RAMs across various malignancy types with their related advantages and disadvantages. A scoping review was conducted using predefined search terms in three scientific databases, including Google Scholar, Science Direct, and PubMed. The search for studies was restricted to original research articles that reported risk assessment models published in the last thirteen years (between 2008 and 2021) to cover the most recently published evidence following the development of the principal risk assessment score in 2008. Data charting of the relevant trials, scores, advantages, and disadvantages were done iteratively considering the malignancy type. Of the initially identified 1115 studies, 39 studies with over 67,680 patients were included in the review. In solid organ malignancy, nine risk assessment scores were generated. The first and most known Khorana risk score still offers the best available risk assessment model when used for high-risk populations with a threshold of 2 and above. However, KRS has a limitation of failure to stratify low-risk patients. The COMPASS-CAT score showed the best performance in the lung carcinoma patients who have a higher prevalence of thrombosis than other malignancy subtypes. In testicular germ cell tumours, Bezan et al RAM is a validated good discriminatory RAM for this malignancy subtype. CAT in haematological malignancy seems to be under-investigated and has multiple disease-related, and treatment-related confounding factors. AL-Ani et al score performed efficiently in acute leukemia. In multiple myeloma, both SAVED and IMPEDED VTE scores showed good performance. Despite the availability of different disease-specific scores in lymphoma-related thrombosis, the standard of care needs to be redefined. Dove Medical Press Ltd 2021 Article PeerReviewed application/pdf en http://irep.iium.edu.my/91290/7/91290_Cancer-Associated%20Thrombosis_Scopus.pdf application/pdf en http://irep.iium.edu.my/91290/13/91290_Cancer-Associated%20Thrombosis.pdf Mosaad, Manar and Elnaem, Mohamed Hassan Abdelaziz and Cheema, Ejaz and Ibrahim, Ismail and Ab Rahman, Jamalludin and Kori, Ahlam Naila and How, Soon Hin (2021) Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies. International Journal of General Medicine, 14. pp. 3881-3897. ISSN 1178-7074 10.2147/IJGM.S320492
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica
spellingShingle	R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica Mosaad, Manar Elnaem, Mohamed Hassan Abdelaziz Cheema, Ejaz Ibrahim, Ismail Ab Rahman, Jamalludin Kori, Ahlam Naila How, Soon Hin Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies
description	Cancer-associated thrombosis (CAT) is a leading cause of death in cancer patients receiving outpatient chemotherapy. The latest guidelines emphasize stratifying the patients in terms of CAT risks periodically. Multiple risk assessment models (RAMs) were developed to classify patients and guide thromboprophylaxis to high-risk patients. This study aimed to discuss and highlight different RAMs across various malignancy types with their related advantages and disadvantages. A scoping review was conducted using predefined search terms in three scientific databases, including Google Scholar, Science Direct, and PubMed. The search for studies was restricted to original research articles that reported risk assessment models published in the last thirteen years (between 2008 and 2021) to cover the most recently published evidence following the development of the principal risk assessment score in 2008. Data charting of the relevant trials, scores, advantages, and disadvantages were done iteratively considering the malignancy type. Of the initially identified 1115 studies, 39 studies with over 67,680 patients were included in the review. In solid organ malignancy, nine risk assessment scores were generated. The first and most known Khorana risk score still offers the best available risk assessment model when used for high-risk populations with a threshold of 2 and above. However, KRS has a limitation of failure to stratify low-risk patients. The COMPASS-CAT score showed the best performance in the lung carcinoma patients who have a higher prevalence of thrombosis than other malignancy subtypes. In testicular germ cell tumours, Bezan et al RAM is a validated good discriminatory RAM for this malignancy subtype. CAT in haematological malignancy seems to be under-investigated and has multiple disease-related, and treatment-related confounding factors. AL-Ani et al score performed efficiently in acute leukemia. In multiple myeloma, both SAVED and IMPEDED VTE scores showed good performance. Despite the availability of different disease-specific scores in lymphoma-related thrombosis, the standard of care needs to be redefined.
format	Article
author	Mosaad, Manar Elnaem, Mohamed Hassan Abdelaziz Cheema, Ejaz Ibrahim, Ismail Ab Rahman, Jamalludin Kori, Ahlam Naila How, Soon Hin
author_facet	Mosaad, Manar Elnaem, Mohamed Hassan Abdelaziz Cheema, Ejaz Ibrahim, Ismail Ab Rahman, Jamalludin Kori, Ahlam Naila How, Soon Hin
author_sort	Mosaad, Manar
title	Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies
title_short	Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies
title_full	Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies
title_fullStr	Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies
title_full_unstemmed	Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies
title_sort	cancer-associated thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies
publisher	Dove Medical Press Ltd
publishDate	2021
url	http://irep.iium.edu.my/91290/7/91290_Cancer-Associated%20Thrombosis_Scopus.pdf http://irep.iium.edu.my/91290/13/91290_Cancer-Associated%20Thrombosis.pdf http://irep.iium.edu.my/91290/
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score	13.211869

Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies

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