Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies
Cancer-associated thrombosis (CAT) is a leading cause of death in cancer patients receiving outpatient chemotherapy. The latest guidelines emphasize stratifying the patients in terms of CAT risks periodically. Multiple risk assessment models (RAMs) were developed to classify patients and guide th...
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2021
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my.iium.irep.912902022-07-15T02:13:29Z http://irep.iium.edu.my/91290/ Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies Mosaad, Manar Elnaem, Mohamed Hassan Abdelaziz Cheema, Ejaz Ibrahim, Ismail Ab Rahman, Jamalludin Kori, Ahlam Naila How, Soon Hin R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica Cancer-associated thrombosis (CAT) is a leading cause of death in cancer patients receiving outpatient chemotherapy. The latest guidelines emphasize stratifying the patients in terms of CAT risks periodically. Multiple risk assessment models (RAMs) were developed to classify patients and guide thromboprophylaxis to high-risk patients. This study aimed to discuss and highlight different RAMs across various malignancy types with their related advantages and disadvantages. A scoping review was conducted using predefined search terms in three scientific databases, including Google Scholar, Science Direct, and PubMed. The search for studies was restricted to original research articles that reported risk assessment models published in the last thirteen years (between 2008 and 2021) to cover the most recently published evidence following the development of the principal risk assessment score in 2008. Data charting of the relevant trials, scores, advantages, and disadvantages were done iteratively considering the malignancy type. Of the initially identified 1115 studies, 39 studies with over 67,680 patients were included in the review. In solid organ malignancy, nine risk assessment scores were generated. The first and most known Khorana risk score still offers the best available risk assessment model when used for high-risk populations with a threshold of 2 and above. However, KRS has a limitation of failure to stratify low-risk patients. The COMPASS-CAT score showed the best performance in the lung carcinoma patients who have a higher prevalence of thrombosis than other malignancy subtypes. In testicular germ cell tumours, Bezan et al RAM is a validated good discriminatory RAM for this malignancy subtype. CAT in haematological malignancy seems to be under-investigated and has multiple disease-related, and treatment-related confounding factors. AL-Ani et al score performed efficiently in acute leukemia. In multiple myeloma, both SAVED and IMPEDED VTE scores showed good performance. Despite the availability of different disease-specific scores in lymphoma-related thrombosis, the standard of care needs to be redefined. Dove Medical Press Ltd 2021 Article PeerReviewed application/pdf en http://irep.iium.edu.my/91290/7/91290_Cancer-Associated%20Thrombosis_Scopus.pdf application/pdf en http://irep.iium.edu.my/91290/13/91290_Cancer-Associated%20Thrombosis.pdf Mosaad, Manar and Elnaem, Mohamed Hassan Abdelaziz and Cheema, Ejaz and Ibrahim, Ismail and Ab Rahman, Jamalludin and Kori, Ahlam Naila and How, Soon Hin (2021) Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies. International Journal of General Medicine, 14. pp. 3881-3897. ISSN 1178-7074 10.2147/IJGM.S320492 |
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| collection |
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| language |
English English |
| topic |
R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica |
| spellingShingle |
R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) RS Pharmacy and materia medica Mosaad, Manar Elnaem, Mohamed Hassan Abdelaziz Cheema, Ejaz Ibrahim, Ismail Ab Rahman, Jamalludin Kori, Ahlam Naila How, Soon Hin Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies |
| description |
Cancer-associated thrombosis (CAT) is a leading cause of death in cancer patients
receiving outpatient chemotherapy. The latest guidelines emphasize stratifying the patients in
terms of CAT risks periodically. Multiple risk assessment models (RAMs) were developed to
classify patients and guide thromboprophylaxis to high-risk patients. This study aimed to
discuss and highlight different RAMs across various malignancy types with their related
advantages and disadvantages. A scoping review was conducted using predefined search
terms in three scientific databases, including Google Scholar, Science Direct, and PubMed.
The search for studies was restricted to original research articles that reported risk assessment models published in the last thirteen years (between 2008 and 2021) to cover the most
recently published evidence following the development of the principal risk assessment score
in 2008. Data charting of the relevant trials, scores, advantages, and disadvantages were done
iteratively considering the malignancy type. Of the initially identified 1115 studies, 39
studies with over 67,680 patients were included in the review. In solid organ malignancy,
nine risk assessment scores were generated. The first and most known Khorana risk score
still offers the best available risk assessment model when used for high-risk populations with
a threshold of 2 and above. However, KRS has a limitation of failure to stratify low-risk
patients. The COMPASS-CAT score showed the best performance in the lung carcinoma
patients who have a higher prevalence of thrombosis than other malignancy subtypes. In
testicular germ cell tumours, Bezan et al RAM is a validated good discriminatory RAM for
this malignancy subtype. CAT in haematological malignancy seems to be under-investigated
and has multiple disease-related, and treatment-related confounding factors. AL-Ani et al
score performed efficiently in acute leukemia. In multiple myeloma, both SAVED and
IMPEDED VTE scores showed good performance. Despite the availability of different
disease-specific scores in lymphoma-related thrombosis, the standard of care needs to be
redefined. |
| format |
Article |
| author |
Mosaad, Manar Elnaem, Mohamed Hassan Abdelaziz Cheema, Ejaz Ibrahim, Ismail Ab Rahman, Jamalludin Kori, Ahlam Naila How, Soon Hin |
| author_facet |
Mosaad, Manar Elnaem, Mohamed Hassan Abdelaziz Cheema, Ejaz Ibrahim, Ismail Ab Rahman, Jamalludin Kori, Ahlam Naila How, Soon Hin |
| author_sort |
Mosaad, Manar |
| title |
Cancer-Associated Thrombosis: a clinical
scoping review of the risk assessment models
across solid tumours and haematological
malignancies |
| title_short |
Cancer-Associated Thrombosis: a clinical
scoping review of the risk assessment models
across solid tumours and haematological
malignancies |
| title_full |
Cancer-Associated Thrombosis: a clinical
scoping review of the risk assessment models
across solid tumours and haematological
malignancies |
| title_fullStr |
Cancer-Associated Thrombosis: a clinical
scoping review of the risk assessment models
across solid tumours and haematological
malignancies |
| title_full_unstemmed |
Cancer-Associated Thrombosis: a clinical
scoping review of the risk assessment models
across solid tumours and haematological
malignancies |
| title_sort |
cancer-associated thrombosis: a clinical
scoping review of the risk assessment models
across solid tumours and haematological
malignancies |
| publisher |
Dove Medical Press Ltd |
| publishDate |
2021 |
| url |
http://irep.iium.edu.my/91290/7/91290_Cancer-Associated%20Thrombosis_Scopus.pdf http://irep.iium.edu.my/91290/13/91290_Cancer-Associated%20Thrombosis.pdf http://irep.iium.edu.my/91290/ |
| _version_ |
1738510110759583744 |
| score |
13.251815 |