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MRI of corpus callosum in patients with autism spectrum disorder in Kuantan

OBjective: To study the integrity of the corpus callosum among autistic children population in Kuantan, Pahang, Malaysia, which is determined by MRI’s diffusion tensor imaging (DTI) parameters, fractional anisotropy (FA) and radial diffusivity (RD). These param- eters represent the direction depende...

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Main Authors: Shamsuddin Perisamy, Rajeev, Abd. Aziz, Azian, Mat Zin, Nora, Hasan, Taufiq Hidayat, Abdul Rahim, Mohamad Shahrir
Format: Article
Language:English
Published: Korean Radiological Society 2021
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/90736/7/90736_MRI%20of%20corpus%20callosum%20in%20patients%20with%20autism.pdf
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spelling my.iium.irep.907362021-07-13T23:43:35Z http://irep.iium.edu.my/90736/ MRI of corpus callosum in patients with autism spectrum disorder in Kuantan Shamsuddin Perisamy, Rajeev Abd. Aziz, Azian Mat Zin, Nora Hasan, Taufiq Hidayat Abdul Rahim, Mohamad Shahrir R Medicine (General) OBjective: To study the integrity of the corpus callosum among autistic children population in Kuantan, Pahang, Malaysia, which is determined by MRI’s diffusion tensor imaging (DTI) parameters, fractional anisotropy (FA) and radial diffusivity (RD). These param- eters represent the direction dependence of water molecules diffusion within the measured tissues. As corpus callosum is saturated with brain white matter tracts, the water molecules diffusion here will be direction dependent. Studies involving foreign populations have shown that there is distortion in the corpus callosum’s DTI parameters in autistic population indicative of microstructural distor- tion. Whether similar findings will be observed in our local autistic population still remains a question. Other gross corpus callosum parameters such as its thickness, length and size are also studied. Materials & Methods: 28 randomly selected autistic children under the International Islamic University Malaysia Medical Centre (IIUMMC), Kuantan follow-up are subjected to MRI scan. Limited MRI sequences including DTI are obtained and analysed. FA, RD, midsagittal thickness at the genu, body and splenium of the corpus callosum as well as its midsagittal length and size are measured. Data are tabulated according to age followed by statistical analysis. Results: A weak negative correlation is found between the age and the FA of the corpus callosum. Other parameters such as the thickness, length and size show weak positive correlation with age. Conclusion: Although the correlation is weak, our study shows that there is evidence of distortion of corpus callosum white matter microstructure in children with autism spectrum disorder in Kuantan, Pahang. Korean Radiological Society 2021-07 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/90736/7/90736_MRI%20of%20corpus%20callosum%20in%20patients%20with%20autism.pdf Shamsuddin Perisamy, Rajeev and Abd. Aziz, Azian and Mat Zin, Nora and Hasan, Taufiq Hidayat and Abdul Rahim, Mohamad Shahrir (2021) MRI of corpus callosum in patients with autism spectrum disorder in Kuantan. Korean Journal of Radiology. S179. ISSN 1229-6929 E-ISSN 2005-8330 https://kjronline.org
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Shamsuddin Perisamy, Rajeev
Abd. Aziz, Azian
Mat Zin, Nora
Hasan, Taufiq Hidayat
Abdul Rahim, Mohamad Shahrir
MRI of corpus callosum in patients with autism spectrum disorder in Kuantan
description OBjective: To study the integrity of the corpus callosum among autistic children population in Kuantan, Pahang, Malaysia, which is determined by MRI’s diffusion tensor imaging (DTI) parameters, fractional anisotropy (FA) and radial diffusivity (RD). These param- eters represent the direction dependence of water molecules diffusion within the measured tissues. As corpus callosum is saturated with brain white matter tracts, the water molecules diffusion here will be direction dependent. Studies involving foreign populations have shown that there is distortion in the corpus callosum’s DTI parameters in autistic population indicative of microstructural distor- tion. Whether similar findings will be observed in our local autistic population still remains a question. Other gross corpus callosum parameters such as its thickness, length and size are also studied. Materials & Methods: 28 randomly selected autistic children under the International Islamic University Malaysia Medical Centre (IIUMMC), Kuantan follow-up are subjected to MRI scan. Limited MRI sequences including DTI are obtained and analysed. FA, RD, midsagittal thickness at the genu, body and splenium of the corpus callosum as well as its midsagittal length and size are measured. Data are tabulated according to age followed by statistical analysis. Results: A weak negative correlation is found between the age and the FA of the corpus callosum. Other parameters such as the thickness, length and size show weak positive correlation with age. Conclusion: Although the correlation is weak, our study shows that there is evidence of distortion of corpus callosum white matter microstructure in children with autism spectrum disorder in Kuantan, Pahang.
format Article
author Shamsuddin Perisamy, Rajeev
Abd. Aziz, Azian
Mat Zin, Nora
Hasan, Taufiq Hidayat
Abdul Rahim, Mohamad Shahrir
author_facet Shamsuddin Perisamy, Rajeev
Abd. Aziz, Azian
Mat Zin, Nora
Hasan, Taufiq Hidayat
Abdul Rahim, Mohamad Shahrir
author_sort Shamsuddin Perisamy, Rajeev
title MRI of corpus callosum in patients with autism spectrum disorder in Kuantan
title_short MRI of corpus callosum in patients with autism spectrum disorder in Kuantan
title_full MRI of corpus callosum in patients with autism spectrum disorder in Kuantan
title_fullStr MRI of corpus callosum in patients with autism spectrum disorder in Kuantan
title_full_unstemmed MRI of corpus callosum in patients with autism spectrum disorder in Kuantan
title_sort mri of corpus callosum in patients with autism spectrum disorder in kuantan
publisher Korean Radiological Society
publishDate 2021
url http://irep.iium.edu.my/90736/7/90736_MRI%20of%20corpus%20callosum%20in%20patients%20with%20autism.pdf
http://irep.iium.edu.my/90736/
https://kjronline.org
_version_ 1706956586567598080
score 13.211869

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