Staff View: The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment

The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment

The second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning its pathogenesis. The use of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetra...

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Main Authors:	Razali, Khairiah, Othman, Noratikah, Mohd Nasir, Mohd Hamzah, Doolaanea, Abd Almonem, Kumar, Jaya, Ibrahim, Wisam Nabeel, Mohamed Ibrahim, Norlinah, Mohamed, Wael Mohamed Yousef
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://irep.iium.edu.my/89368/7/89368_ZP_Review.pdf http://irep.iium.edu.my/89368/ https://www.frontiersin.org/articles/10.3389/fgene.2021.655550/full
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spelling	my.iium.irep.893682021-04-16T06:12:26Z http://irep.iium.edu.my/89368/ The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment Razali, Khairiah Othman, Noratikah Mohd Nasir, Mohd Hamzah Doolaanea, Abd Almonem Kumar, Jaya Ibrahim, Wisam Nabeel Mohamed Ibrahim, Norlinah Mohamed, Wael Mohamed Yousef RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry The second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning its pathogenesis. The use of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the basis of most animal models of PD. MPTP is metabolized by monoamine oxidase B (MAO B) to MPP + and induces the loss of dopaminergic neurons in the substantia nigra in mammals. Zebrafish have been commonly used in developmental biology as a model organism, but owing to its perfect mix of properties, it is now emerging as a model for human diseases. Zebrafish (Danio rerio) are cheap and easy to sustain, evolve rapidly, breed transparent embryos in large amounts, and are readily manipulated by different methods, particularly genetic ones. Furthermore, zebrafish are vertebrate species and mammalian findings obtained from zebrafish may be more applicable than those derived from genetic models of invertebrates such as Drosophila melanogaster and Caenorhabditis elegans. The resemblance cannot be taken for granted, however. The goal of the present review article is to highlight the promise of zebrafish as a PD animal model. As its aminergic structures, MPTP mode of action, and PINK1 roles mimic those of mammalians, zebrafish seems to be a viable model for studying PD. The roles of zebrafish MAO, however, vary from those of the two types of MAO present in mammals. The benefits unique to zebrafish, such as the ability to perform large-scale genetic or drug screens, should be exploited in future experiments utilizing zebrafish PD models. Frontiers Media S.A. 2021-04-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/89368/7/89368_ZP_Review.pdf Razali, Khairiah and Othman, Noratikah and Mohd Nasir, Mohd Hamzah and Doolaanea, Abd Almonem and Kumar, Jaya and Ibrahim, Wisam Nabeel and Mohamed Ibrahim, Norlinah and Mohamed, Wael Mohamed Yousef (2021) The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment. Frontiers In Genetics, 12. pp. 1-17. ISSN 1664-8021 https://www.frontiersin.org/articles/10.3389/fgene.2021.655550/full 10.3389/fgene.2021.655550
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Razali, Khairiah Othman, Noratikah Mohd Nasir, Mohd Hamzah Doolaanea, Abd Almonem Kumar, Jaya Ibrahim, Wisam Nabeel Mohamed Ibrahim, Norlinah Mohamed, Wael Mohamed Yousef The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment
description	The second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning its pathogenesis. The use of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the basis of most animal models of PD. MPTP is metabolized by monoamine oxidase B (MAO B) to MPP + and induces the loss of dopaminergic neurons in the substantia nigra in mammals. Zebrafish have been commonly used in developmental biology as a model organism, but owing to its perfect mix of properties, it is now emerging as a model for human diseases. Zebrafish (Danio rerio) are cheap and easy to sustain, evolve rapidly, breed transparent embryos in large amounts, and are readily manipulated by different methods, particularly genetic ones. Furthermore, zebrafish are vertebrate species and mammalian findings obtained from zebrafish may be more applicable than those derived from genetic models of invertebrates such as Drosophila melanogaster and Caenorhabditis elegans. The resemblance cannot be taken for granted, however. The goal of the present review article is to highlight the promise of zebrafish as a PD animal model. As its aminergic structures, MPTP mode of action, and PINK1 roles mimic those of mammalians, zebrafish seems to be a viable model for studying PD. The roles of zebrafish MAO, however, vary from those of the two types of MAO present in mammals. The benefits unique to zebrafish, such as the ability to perform large-scale genetic or drug screens, should be exploited in future experiments utilizing zebrafish PD models.
format	Article
author	Razali, Khairiah Othman, Noratikah Mohd Nasir, Mohd Hamzah Doolaanea, Abd Almonem Kumar, Jaya Ibrahim, Wisam Nabeel Mohamed Ibrahim, Norlinah Mohamed, Wael Mohamed Yousef
author_facet	Razali, Khairiah Othman, Noratikah Mohd Nasir, Mohd Hamzah Doolaanea, Abd Almonem Kumar, Jaya Ibrahim, Wisam Nabeel Mohamed Ibrahim, Norlinah Mohamed, Wael Mohamed Yousef
author_sort	Razali, Khairiah
title	The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment
title_short	The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment
title_full	The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment
title_fullStr	The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment
title_full_unstemmed	The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment
title_sort	promise of the zebrafish model for parkinson’s disease: today’s science and tomorrow’s treatment
publisher	Frontiers Media S.A.
publishDate	2021
url	http://irep.iium.edu.my/89368/7/89368_ZP_Review.pdf http://irep.iium.edu.my/89368/ https://www.frontiersin.org/articles/10.3389/fgene.2021.655550/full
_version_	1698696756796063744
score	13.211869

The promise of the Zebrafish model for Parkinson’s disease: today’s science and tomorrow’s treatment

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