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Malignant lung carcinoid tumour

*Introduction* Lung carcinoid tumor comprises 1-2% of all lung cancer however atypical lung carcinoid carry high risk of malignant transformation. Carcinoids are strongly and diffusely positive for neuroendocrine markers and commonly used markers include synaptophysin, chromogranin A, and CD56/NCAM...

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Main Authors:	Zainulabid, Ummu Afeera, Abdul Razak, Megat Razeem, How, Soon Hin, Ibrahim, Aishah, Hassan, Nurhidayah, Harun, Norra, Abdul Ghani, Fatimatulzahra
Format:	Conference or Workshop Item
Language:	English English English
Published:	2019
Subjects:	RC731 Specialties of Internal Medicine-Diseases of The Respiratory System
Online Access:	http://irep.iium.edu.my/88223/2/MTS%202019%20CASE%20REPORT%20POSTER%20PRESENTATION%20ACCEPTANCE%20LETTER%20DR%20UMMU%20AFEERA%20BINTI%20ZAINULABID%20-%20abstractID49%202.pdf http://irep.iium.edu.my/88223/3/Malignant%20lung%20carcinoid.pdf http://irep.iium.edu.my/88223/18/Image.pdf http://irep.iium.edu.my/88223/
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spelling	my.iium.irep.882232022-12-08T04:38:24Z http://irep.iium.edu.my/88223/ Malignant lung carcinoid tumour Zainulabid, Ummu Afeera Abdul Razak, Megat Razeem How, Soon Hin Ibrahim, Aishah Hassan, Nurhidayah Harun, Norra Abdul Ghani, Fatimatulzahra RC731 Specialties of Internal Medicine-Diseases of The Respiratory System Introduction Lung carcinoid tumor comprises 1-2% of all lung cancer however atypical lung carcinoid carry high risk of malignant transformation. Carcinoids are strongly and diffusely positive for neuroendocrine markers and commonly used markers include synaptophysin, chromogranin A, and CD56/NCAM. Case Report A 43 year old lady presented initially to surgical team with history of chronic diarrhoea for more than 20 times for a year. Further history suggests that she had flushing of the face. She had significant loss of weight nearly 18 kg. OGDS done with normal finding and colonoscope revealed multiple none bleeding cecal diverticulum. Clinically patient had hepatomegaly thus decided by surgical team for CT liver and subsequently CT Thorax (based on CT liver finding). CT liver revealed multiple liver masses and incidental finding of right lung mass. CECT thorax which was ordered subsequently captured a minimally enhancing irregular hypodense mass at medial segment of right lower lobe measuring 4.1 cm x 3.2 cm x 2.2 cm with evident of bone metastasis. Patient was referred to respiratory team for further management. Bronchoscopy was done and noted narrowed opening of right lower lobe medial segment and unable to pass scope further but can see mass at tertiary carina. There is no endobronchial lesion and transbronchial lung biopsy (TBLB) under fluoroscopy was done. Histopathology report is consistent with atypical carcinoid. The neoplastic cells are strong and diffusely positive for Chromagranin A, Synaptophysin, CD56 and focally positive for CK7. A full diagnosis of malignant lung carcinoid with liver and bone metastasis was made and patient was referred to oncology team for Dotatate PET scan, initiation of sandostatin and further management. Conclusion Physician should always have high suspicious and include a differential diagnosis of carcinoid syndrome in a patient with chronic diarrhea and flushing despite of its rarity. 2019-07-18 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/88223/2/MTS%202019%20CASE%20REPORT%20POSTER%20PRESENTATION%20ACCEPTANCE%20LETTER%20DR%20UMMU%20AFEERA%20BINTI%20ZAINULABID%20-%20abstractID49%202.pdf application/pdf en http://irep.iium.edu.my/88223/3/Malignant%20lung%20carcinoid.pdf application/pdf en http://irep.iium.edu.my/88223/18/Image.pdf Zainulabid, Ummu Afeera and Abdul Razak, Megat Razeem and How, Soon Hin and Ibrahim, Aishah and Hassan, Nurhidayah and Harun, Norra and Abdul Ghani, Fatimatulzahra (2019) Malignant lung carcinoid tumour. In: Malaysian Thoracic Society Congress 2019, 18th- 21st July 2019, The Royale Chulan Hotel, Kuala Lumpur Malaysia.
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English English
topic	RC731 Specialties of Internal Medicine-Diseases of The Respiratory System
spellingShingle	RC731 Specialties of Internal Medicine-Diseases of The Respiratory System Zainulabid, Ummu Afeera Abdul Razak, Megat Razeem How, Soon Hin Ibrahim, Aishah Hassan, Nurhidayah Harun, Norra Abdul Ghani, Fatimatulzahra Malignant lung carcinoid tumour
description	Introduction Lung carcinoid tumor comprises 1-2% of all lung cancer however atypical lung carcinoid carry high risk of malignant transformation. Carcinoids are strongly and diffusely positive for neuroendocrine markers and commonly used markers include synaptophysin, chromogranin A, and CD56/NCAM. Case Report A 43 year old lady presented initially to surgical team with history of chronic diarrhoea for more than 20 times for a year. Further history suggests that she had flushing of the face. She had significant loss of weight nearly 18 kg. OGDS done with normal finding and colonoscope revealed multiple none bleeding cecal diverticulum. Clinically patient had hepatomegaly thus decided by surgical team for CT liver and subsequently CT Thorax (based on CT liver finding). CT liver revealed multiple liver masses and incidental finding of right lung mass. CECT thorax which was ordered subsequently captured a minimally enhancing irregular hypodense mass at medial segment of right lower lobe measuring 4.1 cm x 3.2 cm x 2.2 cm with evident of bone metastasis. Patient was referred to respiratory team for further management. Bronchoscopy was done and noted narrowed opening of right lower lobe medial segment and unable to pass scope further but can see mass at tertiary carina. There is no endobronchial lesion and transbronchial lung biopsy (TBLB) under fluoroscopy was done. Histopathology report is consistent with atypical carcinoid. The neoplastic cells are strong and diffusely positive for Chromagranin A, Synaptophysin, CD56 and focally positive for CK7. A full diagnosis of malignant lung carcinoid with liver and bone metastasis was made and patient was referred to oncology team for Dotatate PET scan, initiation of sandostatin and further management. Conclusion Physician should always have high suspicious and include a differential diagnosis of carcinoid syndrome in a patient with chronic diarrhea and flushing despite of its rarity.
format	Conference or Workshop Item
author	Zainulabid, Ummu Afeera Abdul Razak, Megat Razeem How, Soon Hin Ibrahim, Aishah Hassan, Nurhidayah Harun, Norra Abdul Ghani, Fatimatulzahra
author_facet	Zainulabid, Ummu Afeera Abdul Razak, Megat Razeem How, Soon Hin Ibrahim, Aishah Hassan, Nurhidayah Harun, Norra Abdul Ghani, Fatimatulzahra
author_sort	Zainulabid, Ummu Afeera
title	Malignant lung carcinoid tumour
title_short	Malignant lung carcinoid tumour
title_full	Malignant lung carcinoid tumour
title_fullStr	Malignant lung carcinoid tumour
title_full_unstemmed	Malignant lung carcinoid tumour
title_sort	malignant lung carcinoid tumour
publishDate	2019
url	http://irep.iium.edu.my/88223/2/MTS%202019%20CASE%20REPORT%20POSTER%20PRESENTATION%20ACCEPTANCE%20LETTER%20DR%20UMMU%20AFEERA%20BINTI%20ZAINULABID%20-%20abstractID49%202.pdf http://irep.iium.edu.my/88223/3/Malignant%20lung%20carcinoid.pdf http://irep.iium.edu.my/88223/18/Image.pdf http://irep.iium.edu.my/88223/
_version_	1752146275522838528
score	13.211869

Malignant lung carcinoid tumour

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