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High prevalence of thyroid antibodies in urban population of peninsular Malaysia

Thyroid antibodies are closely related to autoimmune thyroid disorders. To date, there are no data on the prevalence of these antibodies among the Malaysian population. This study aimed to determine the prevalence of thyroid antibodies; and the factors associated with thyroid antibodies in the Malay...

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Main Authors: Shahar, Mohammad Arif, Omar, Ahmad Marzuki, A. Wahab, Norasyikin, Sukor, Norlela, Kamaruddin, Nor Azmi
Format: Article
Language:English
English
English
Published: International Islamic University Malaysia 2020
Subjects:
R Medicine (General)
RC582 Specialities of Internal Medicine- Immunologic Diseases
Online Access:http://irep.iium.edu.my/87842/1/87842_High%20Prevalence%20of%20Thyroid.pdf
http://irep.iium.edu.my/87842/2/87842_High%20Prevalence%20of%20Thyroid_SCOPUS.pdf
http://irep.iium.edu.my/87842/12/87842_High%20Prevalence%20of%20Thyroid_WOS.pdf
http://irep.iium.edu.my/87842/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/1559/1042
https://doi.org/10.31436/imjm.v19i2.1559
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spelling my.iium.irep.878422021-01-15T05:30:43Z http://irep.iium.edu.my/87842/ High prevalence of thyroid antibodies in urban population of peninsular Malaysia Shahar, Mohammad Arif Omar, Ahmad Marzuki A. Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi R Medicine (General) RC582 Specialities of Internal Medicine- Immunologic Diseases Thyroid antibodies are closely related to autoimmune thyroid disorders. To date, there are no data on the prevalence of these antibodies among the Malaysian population. This study aimed to determine the prevalence of thyroid antibodies; and the factors associated with thyroid antibodies in the Malaysian adult population. MATERIALS AND METHODS: A cross-sectional study was performed in 5 pre-assigned regions in Peninsular Malaysia. Participants' sociodemographic profile and medical history were recorded. Physical examinations were done looking for abnormalities of the thyroid gland and signs of thyroid dysfunctions. Fifteen mils of blood were withdrawn and analysed for thyroid function, anti-thyroperoxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies at a central laboratory. RESULTS: Among the total of 2190 respondents, the overall prevalence of positive anti-TPO and anti-TG antibodies were 12.2% and 12.1%, respectively; mainly found in urban and coastal areas. Only 7% to 9% of those with positive anti-TPO or anti-TG antibodies had either hypo- or hyperthyroidism. The predictors for positive anti-TPO antibody were female [adjusted OR 1.7 (95%CI: 1.2-2.4); p=0.001], Indian [adjusted OR 1.9 (95%CI: 1.1-3.1); p=0.020], and having a goitre [adjusted OR 1.8 (95%CI: 1.2-2.8), p=0.004]. The predictors of positive anti-TG antibody was female [adjusted OR 2.3 (95%CI: 1.6-3.3); p<0.001], and having a goitre [adjusted OR 2.0 (95%CI: 1.3-3.4), p=0.001]. Those living in rural areas had 38% lower risk of having positive anti-TG. CONCLUSIONS: The prevalence of positive anti-TPO and anti-TG antibodies were 12.2% and 12.1%, respectively; were higher among the urban and coastal populations. Those living in rural areas had lower risks of anti-TG antibody. (258 words). © 2020 International Islamic University Malaysia. International Islamic University Malaysia 2020-07-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/87842/1/87842_High%20Prevalence%20of%20Thyroid.pdf application/pdf en http://irep.iium.edu.my/87842/2/87842_High%20Prevalence%20of%20Thyroid_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/87842/12/87842_High%20Prevalence%20of%20Thyroid_WOS.pdf Shahar, Mohammad Arif and Omar, Ahmad Marzuki and A. Wahab, Norasyikin and Sukor, Norlela and Kamaruddin, Nor Azmi (2020) High prevalence of thyroid antibodies in urban population of peninsular Malaysia. International Medical Journal Malaysia, 19 (2). pp. 3-12. ISSN 1823-4631 https://journals.iium.edu.my/kom/index.php/imjm/article/view/1559/1042 https://doi.org/10.31436/imjm.v19i2.1559
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic R Medicine (General)
RC582 Specialities of Internal Medicine- Immunologic Diseases
spellingShingle R Medicine (General)
RC582 Specialities of Internal Medicine- Immunologic Diseases
Shahar, Mohammad Arif
Omar, Ahmad Marzuki
A. Wahab, Norasyikin
Sukor, Norlela
Kamaruddin, Nor Azmi
High prevalence of thyroid antibodies in urban population of peninsular Malaysia
description Thyroid antibodies are closely related to autoimmune thyroid disorders. To date, there are no data on the prevalence of these antibodies among the Malaysian population. This study aimed to determine the prevalence of thyroid antibodies; and the factors associated with thyroid antibodies in the Malaysian adult population. MATERIALS AND METHODS: A cross-sectional study was performed in 5 pre-assigned regions in Peninsular Malaysia. Participants' sociodemographic profile and medical history were recorded. Physical examinations were done looking for abnormalities of the thyroid gland and signs of thyroid dysfunctions. Fifteen mils of blood were withdrawn and analysed for thyroid function, anti-thyroperoxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies at a central laboratory. RESULTS: Among the total of 2190 respondents, the overall prevalence of positive anti-TPO and anti-TG antibodies were 12.2% and 12.1%, respectively; mainly found in urban and coastal areas. Only 7% to 9% of those with positive anti-TPO or anti-TG antibodies had either hypo- or hyperthyroidism. The predictors for positive anti-TPO antibody were female [adjusted OR 1.7 (95%CI: 1.2-2.4); p=0.001], Indian [adjusted OR 1.9 (95%CI: 1.1-3.1); p=0.020], and having a goitre [adjusted OR 1.8 (95%CI: 1.2-2.8), p=0.004]. The predictors of positive anti-TG antibody was female [adjusted OR 2.3 (95%CI: 1.6-3.3); p<0.001], and having a goitre [adjusted OR 2.0 (95%CI: 1.3-3.4), p=0.001]. Those living in rural areas had 38% lower risk of having positive anti-TG. CONCLUSIONS: The prevalence of positive anti-TPO and anti-TG antibodies were 12.2% and 12.1%, respectively; were higher among the urban and coastal populations. Those living in rural areas had lower risks of anti-TG antibody. (258 words). © 2020 International Islamic University Malaysia.
format Article
author Shahar, Mohammad Arif
Omar, Ahmad Marzuki
A. Wahab, Norasyikin
Sukor, Norlela
Kamaruddin, Nor Azmi
author_facet Shahar, Mohammad Arif
Omar, Ahmad Marzuki
A. Wahab, Norasyikin
Sukor, Norlela
Kamaruddin, Nor Azmi
author_sort Shahar, Mohammad Arif
title High prevalence of thyroid antibodies in urban population of peninsular Malaysia
title_short High prevalence of thyroid antibodies in urban population of peninsular Malaysia
title_full High prevalence of thyroid antibodies in urban population of peninsular Malaysia
title_fullStr High prevalence of thyroid antibodies in urban population of peninsular Malaysia
title_full_unstemmed High prevalence of thyroid antibodies in urban population of peninsular Malaysia
title_sort high prevalence of thyroid antibodies in urban population of peninsular malaysia
publisher International Islamic University Malaysia
publishDate 2020
url http://irep.iium.edu.my/87842/1/87842_High%20Prevalence%20of%20Thyroid.pdf
http://irep.iium.edu.my/87842/2/87842_High%20Prevalence%20of%20Thyroid_SCOPUS.pdf
http://irep.iium.edu.my/87842/12/87842_High%20Prevalence%20of%20Thyroid_WOS.pdf
http://irep.iium.edu.my/87842/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/1559/1042
https://doi.org/10.31436/imjm.v19i2.1559
_version_ 1690370772061650944
score 13.211869

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