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Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era

Purpose To compare the outcomes of infants with a right (RCDH) versus a left-sided (LCDH) congenital diaphragmatic hernia (CDH) and whether these differed according to whether the infants had undergone fetoscopic tracheal occlusion (FETO). Methods Demographics, the type of surgical repair, preopera...

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Main Authors: Ali, Kamal, Dassios, Theodore, Syed Abd Hamid, Syed Abdul Khaliq, Williams, Emma E., Tamura, Kentaro, Davenport, Mark, Greenough, Anne
Format: Article
Language:English
English
Published: Springer Verlag 2019
Subjects:
RD Surgery
RJ101 Child Health. Child health services
Online Access:http://irep.iium.edu.my/87517/7/87517_Outcomes%20of%20infants%20with%20congenital%20diaphragmatic%20hernia.pdf
http://irep.iium.edu.my/87517/8/87517_Outcomes%20of%20infants%20with%20congenital%20diaphragmatic%20hernia_Scopus.pdf
http://irep.iium.edu.my/87517/
https://doi.org/10.1007/s00383-019-04484-3
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spelling my.iium.irep.875172021-01-08T01:13:26Z http://irep.iium.edu.my/87517/ Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era Ali, Kamal Dassios, Theodore Syed Abd Hamid, Syed Abdul Khaliq Williams, Emma E. Tamura, Kentaro Davenport, Mark Greenough, Anne RD Surgery RJ101 Child Health. Child health services Purpose To compare the outcomes of infants with a right (RCDH) versus a left-sided (LCDH) congenital diaphragmatic hernia (CDH) and whether these differed according to whether the infants had undergone fetoscopic tracheal occlusion (FETO). Methods Demographics, the type of surgical repair, preoperative and postoperative courses and respiratory, gastrointestinal, surgical and skeletal morbidities at follow-up were compared between infants with a RCDH or LCDH. A sub-analysis was undertaken in those who had undergone FETO. Results During the study period, there were 167 infants with a LCDH and 24 with a RCDH; 106 underwent FETO (15 RCDH). Overall, the need for inhaled nitric oxide (p = 0.036) was higher in the RCDH group and, at follow-up, infants with RCDH were more likely to have a hernia recurrence (p = 0.043), pectus deformity (p = 0.019), scoliosis (p = 0.029) and suffer chronic respiratory morbidity (p = 0.001). There were, however, no significant differences in short term or long term outcomes (hernia recurrence (p = 0.237), pectus deformity (p = 0.322), scoliosis (p = 0.0174) or chronic respiratory morbidity (p = 0.326)) between infants with a right or left sided CDH who had undergone FETO. Conclusion Overall, infants with a RCDH compared to those with a LCDH had greater long-term morbidity, but not if they had undergone FETO. Springer Verlag 2019-05-14 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/87517/7/87517_Outcomes%20of%20infants%20with%20congenital%20diaphragmatic%20hernia.pdf application/pdf en http://irep.iium.edu.my/87517/8/87517_Outcomes%20of%20infants%20with%20congenital%20diaphragmatic%20hernia_Scopus.pdf Ali, Kamal and Dassios, Theodore and Syed Abd Hamid, Syed Abdul Khaliq and Williams, Emma E. and Tamura, Kentaro and Davenport, Mark and Greenough, Anne (2019) Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era. Pediatric Surgery International, 35 (7). pp. 743-747. ISSN 0179-0358 (Unpublished) https://doi.org/10.1007/s00383-019-04484-3 10.1007/s00383-019-04484-3
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RD Surgery
RJ101 Child Health. Child health services
spellingShingle RD Surgery
RJ101 Child Health. Child health services
Ali, Kamal
Dassios, Theodore
Syed Abd Hamid, Syed Abdul Khaliq
Williams, Emma E.
Tamura, Kentaro
Davenport, Mark
Greenough, Anne
Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era
description Purpose To compare the outcomes of infants with a right (RCDH) versus a left-sided (LCDH) congenital diaphragmatic hernia (CDH) and whether these differed according to whether the infants had undergone fetoscopic tracheal occlusion (FETO). Methods Demographics, the type of surgical repair, preoperative and postoperative courses and respiratory, gastrointestinal, surgical and skeletal morbidities at follow-up were compared between infants with a RCDH or LCDH. A sub-analysis was undertaken in those who had undergone FETO. Results During the study period, there were 167 infants with a LCDH and 24 with a RCDH; 106 underwent FETO (15 RCDH). Overall, the need for inhaled nitric oxide (p = 0.036) was higher in the RCDH group and, at follow-up, infants with RCDH were more likely to have a hernia recurrence (p = 0.043), pectus deformity (p = 0.019), scoliosis (p = 0.029) and suffer chronic respiratory morbidity (p = 0.001). There were, however, no significant differences in short term or long term outcomes (hernia recurrence (p = 0.237), pectus deformity (p = 0.322), scoliosis (p = 0.0174) or chronic respiratory morbidity (p = 0.326)) between infants with a right or left sided CDH who had undergone FETO. Conclusion Overall, infants with a RCDH compared to those with a LCDH had greater long-term morbidity, but not if they had undergone FETO.
format Article
author Ali, Kamal
Dassios, Theodore
Syed Abd Hamid, Syed Abdul Khaliq
Williams, Emma E.
Tamura, Kentaro
Davenport, Mark
Greenough, Anne
author_facet Ali, Kamal
Dassios, Theodore
Syed Abd Hamid, Syed Abdul Khaliq
Williams, Emma E.
Tamura, Kentaro
Davenport, Mark
Greenough, Anne
author_sort Ali, Kamal
title Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era
title_short Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era
title_full Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era
title_fullStr Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era
title_full_unstemmed Outcomes of infants with congenital diaphragmatic hernia by side of defect in the FETO era
title_sort outcomes of infants with congenital diaphragmatic hernia by side of defect in the feto era
publisher Springer Verlag
publishDate 2019
url http://irep.iium.edu.my/87517/7/87517_Outcomes%20of%20infants%20with%20congenital%20diaphragmatic%20hernia.pdf
http://irep.iium.edu.my/87517/8/87517_Outcomes%20of%20infants%20with%20congenital%20diaphragmatic%20hernia_Scopus.pdf
http://irep.iium.edu.my/87517/
https://doi.org/10.1007/s00383-019-04484-3
_version_ 1688547795034701824
score 13.211869

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