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The illustration of a rat large intestine: a model for the effect of carcinogens

Introduction: Rat large intestine is an established model to study the effect of carcinogens. There are several distinctive features among mammalian gastrointestinal tracts in gross anatomy but they share some basic similar structures. The variety in digestive system relies on its physiology. Rats r...

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Main Authors: Zulkiflee, Khodijah, Buyong, Zunariah, Hamdan, Asmah Hanim
Format: Conference or Workshop Item
Language:English
English
Published: 2017
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/87501/1/Local%20conference%20-%202017%20-%20MRS%209%20Aug%20Poster%20Rats%20colon.pdf
http://irep.iium.edu.my/87501/7/62376_The%20illustration%20of%20a%20rat%20large%20intestine.pdf
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spelling my.iium.irep.875012021-01-20T01:07:20Z http://irep.iium.edu.my/87501/ The illustration of a rat large intestine: a model for the effect of carcinogens Zulkiflee, Khodijah Buyong, Zunariah Hamdan, Asmah Hanim RB Pathology Introduction: Rat large intestine is an established model to study the effect of carcinogens. There are several distinctive features among mammalian gastrointestinal tracts in gross anatomy but they share some basic similar structures. The variety in digestive system relies on its physiology. Rats rarely eat high fatty diets, thus the function of gall bladder become less significant in their digestive system and this is justified by the fact that rats have none. Rats have large caecum designated for their fermentation chamber to digest cellulose. Another notable difference is the size and length of colon itself, in which human colon is significantly bigger and longer. We aimed to demonstrate the gross anatomy and histology of rat digestive system particularly the large intestine. Materials and method: Abdominal cavity was opened and rat digestive system in situ was identified. The whole digestive tube was released from the mesentery. The length of large intestine was measured and flushed with phosphate buffered saline to remove its contents. Representative samples from the large intestine were taken and fixed with Carnoy’s solution and neutral buffered formalin for histological study. Results: The most obvious region in rat large intestine was the caecum and no obvious partitions of large intestine as in human. Nevertheless, the histology of rat large intestine resembled the human. Gall bladder and appendix were absent in rats. Conclusion: Besides smaller in size and length, rat large intestine has a larger caecum compared to human. There is similarity between the large intestinal wall in rat and human microscopically. 2017-08-08 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/87501/1/Local%20conference%20-%202017%20-%20MRS%209%20Aug%20Poster%20Rats%20colon.pdf application/pdf en http://irep.iium.edu.my/87501/7/62376_The%20illustration%20of%20a%20rat%20large%20intestine.pdf Zulkiflee, Khodijah and Buyong, Zunariah and Hamdan, Asmah Hanim (2017) The illustration of a rat large intestine: a model for the effect of carcinogens. In: Medical Research Symposium 2017, 10th August 2017, Kuantan, Pahang Darul Makmur, Malaysia. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RB Pathology
spellingShingle RB Pathology
Zulkiflee, Khodijah
Buyong, Zunariah
Hamdan, Asmah Hanim
The illustration of a rat large intestine: a model for the effect of carcinogens
description Introduction: Rat large intestine is an established model to study the effect of carcinogens. There are several distinctive features among mammalian gastrointestinal tracts in gross anatomy but they share some basic similar structures. The variety in digestive system relies on its physiology. Rats rarely eat high fatty diets, thus the function of gall bladder become less significant in their digestive system and this is justified by the fact that rats have none. Rats have large caecum designated for their fermentation chamber to digest cellulose. Another notable difference is the size and length of colon itself, in which human colon is significantly bigger and longer. We aimed to demonstrate the gross anatomy and histology of rat digestive system particularly the large intestine. Materials and method: Abdominal cavity was opened and rat digestive system in situ was identified. The whole digestive tube was released from the mesentery. The length of large intestine was measured and flushed with phosphate buffered saline to remove its contents. Representative samples from the large intestine were taken and fixed with Carnoy’s solution and neutral buffered formalin for histological study. Results: The most obvious region in rat large intestine was the caecum and no obvious partitions of large intestine as in human. Nevertheless, the histology of rat large intestine resembled the human. Gall bladder and appendix were absent in rats. Conclusion: Besides smaller in size and length, rat large intestine has a larger caecum compared to human. There is similarity between the large intestinal wall in rat and human microscopically.
format Conference or Workshop Item
author Zulkiflee, Khodijah
Buyong, Zunariah
Hamdan, Asmah Hanim
author_facet Zulkiflee, Khodijah
Buyong, Zunariah
Hamdan, Asmah Hanim
author_sort Zulkiflee, Khodijah
title The illustration of a rat large intestine: a model for the effect of carcinogens
title_short The illustration of a rat large intestine: a model for the effect of carcinogens
title_full The illustration of a rat large intestine: a model for the effect of carcinogens
title_fullStr The illustration of a rat large intestine: a model for the effect of carcinogens
title_full_unstemmed The illustration of a rat large intestine: a model for the effect of carcinogens
title_sort illustration of a rat large intestine: a model for the effect of carcinogens
publishDate 2017
url http://irep.iium.edu.my/87501/1/Local%20conference%20-%202017%20-%20MRS%209%20Aug%20Poster%20Rats%20colon.pdf
http://irep.iium.edu.my/87501/7/62376_The%20illustration%20of%20a%20rat%20large%20intestine.pdf
http://irep.iium.edu.my/87501/
_version_ 1690370755514073088
score 13.211869

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