Cover Image

Seroconversion after recombinant Hepatitis B vaccination

Background: Hepatitis B virus infection is an important public health problem with significant morbidity and mortality. Recombinant hepatitis B vaccine for the prevention of hepatitis B virus infection is in practice in different parts of the world since its availability in 1986. Government of Bangl...

Full description

Saved in:
Bibliographic Details
Main Authors: Guho, Abhijit, Ahad, Md Abdul, Salam, Md. Abdus, Alim, Md Abdul, Haque, A.K.M Enamul, Islam, Quazi Tarikul
Format: Article
Language:English
Published: Bangladesh Society of Medicine 2010
Subjects:
QR180 Immunology
Online Access:http://irep.iium.edu.my/87312/1/Seroconversion%20after%20HBV%20vaccination.pdf
http://irep.iium.edu.my/87312/
http://doi.org/10.3329/jom.v11i2.5461
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.87312
record_format dspace
spelling my.iium.irep.873122021-01-07T07:46:19Z http://irep.iium.edu.my/87312/ Seroconversion after recombinant Hepatitis B vaccination Guho, Abhijit Ahad, Md Abdul Salam, Md. Abdus Alim, Md Abdul Haque, A.K.M Enamul Islam, Quazi Tarikul QR180 Immunology Background: Hepatitis B virus infection is an important public health problem with significant morbidity and mortality. Recombinant hepatitis B vaccine for the prevention of hepatitis B virus infection is in practice in different parts of the world since its availability in 1986. Government of Bangladesh has also included hepatitis B vaccine in EPI schedule since 2005. Materials and methods: This study was carried out to assess the seroconversion status among hepatitis B vaccinated individuals. A total of 190 individuals including 150 vaccinated persons and 40 non-vaccinated apparently healthy individuals were included as study population. Sources of vaccinated persons were from both EPI and non-EPI schedule of vaccination. Age and sex matched non-vaccinated individuals served as controls for the study. All individuals constituting the study population were screened for HBsAg by Immunochromatographic strip test and only HBsAg-negative persons were included for estimation of their anti-HBs titer. Results: Out of 150 vaccinated individuals, 133(88.67%) were found to have anti-HBs titer in the protective level (>10 IU/L), while 17(11.33%) individuals had anti-HBs titer below the protective level (<10 IU/L). All non-vaccinated controls had anti-HBs titers below the protective level. Regarding immune response developed among vaccinated individuals, 67.78%, 23.33% and 8.89% were good-responders, hypo-responders and non-responders respectively. Mean titer of anti-HBs was found significantly higher among recipients who received booster dose than those who received 3 doses schedule (863.39 IU/L vs. 262.40 IU/L), indicating high antibody titer develops after booster dose. Vaccinated group included 85 (56.67%) men and 65 (43.33%) women with protective level of anti-HBs titer found in 85.88% male and 92.31% female individuals. There was no significant difference of anti-HBs titer between male and female (p>0.05). Vaccinated individuals from lower socioeconomic condition have had comparatively low rate of protective antibody than people from middle and upper classes. Conclusion: Recombinant HB vaccine induces good level of protective immunity among vaccinated persons. Bangladesh Society of Medicine 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/87312/1/Seroconversion%20after%20HBV%20vaccination.pdf Guho, Abhijit and Ahad, Md Abdul and Salam, Md. Abdus and Alim, Md Abdul and Haque, A.K.M Enamul and Islam, Quazi Tarikul (2010) Seroconversion after recombinant Hepatitis B vaccination. Journal of Medicine, 11 (2). pp. 143-150. ISSN 1997-9797 E-ISSN 2075-5384 http://doi.org/10.3329/jom.v11i2.5461 doi:10.3329/jom.v11i2.5461
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QR180 Immunology
spellingShingle QR180 Immunology
Guho, Abhijit
Ahad, Md Abdul
Salam, Md. Abdus
Alim, Md Abdul
Haque, A.K.M Enamul
Islam, Quazi Tarikul
Seroconversion after recombinant Hepatitis B vaccination
description Background: Hepatitis B virus infection is an important public health problem with significant morbidity and mortality. Recombinant hepatitis B vaccine for the prevention of hepatitis B virus infection is in practice in different parts of the world since its availability in 1986. Government of Bangladesh has also included hepatitis B vaccine in EPI schedule since 2005. Materials and methods: This study was carried out to assess the seroconversion status among hepatitis B vaccinated individuals. A total of 190 individuals including 150 vaccinated persons and 40 non-vaccinated apparently healthy individuals were included as study population. Sources of vaccinated persons were from both EPI and non-EPI schedule of vaccination. Age and sex matched non-vaccinated individuals served as controls for the study. All individuals constituting the study population were screened for HBsAg by Immunochromatographic strip test and only HBsAg-negative persons were included for estimation of their anti-HBs titer. Results: Out of 150 vaccinated individuals, 133(88.67%) were found to have anti-HBs titer in the protective level (>10 IU/L), while 17(11.33%) individuals had anti-HBs titer below the protective level (<10 IU/L). All non-vaccinated controls had anti-HBs titers below the protective level. Regarding immune response developed among vaccinated individuals, 67.78%, 23.33% and 8.89% were good-responders, hypo-responders and non-responders respectively. Mean titer of anti-HBs was found significantly higher among recipients who received booster dose than those who received 3 doses schedule (863.39 IU/L vs. 262.40 IU/L), indicating high antibody titer develops after booster dose. Vaccinated group included 85 (56.67%) men and 65 (43.33%) women with protective level of anti-HBs titer found in 85.88% male and 92.31% female individuals. There was no significant difference of anti-HBs titer between male and female (p>0.05). Vaccinated individuals from lower socioeconomic condition have had comparatively low rate of protective antibody than people from middle and upper classes. Conclusion: Recombinant HB vaccine induces good level of protective immunity among vaccinated persons.
format Article
author Guho, Abhijit
Ahad, Md Abdul
Salam, Md. Abdus
Alim, Md Abdul
Haque, A.K.M Enamul
Islam, Quazi Tarikul
author_facet Guho, Abhijit
Ahad, Md Abdul
Salam, Md. Abdus
Alim, Md Abdul
Haque, A.K.M Enamul
Islam, Quazi Tarikul
author_sort Guho, Abhijit
title Seroconversion after recombinant Hepatitis B vaccination
title_short Seroconversion after recombinant Hepatitis B vaccination
title_full Seroconversion after recombinant Hepatitis B vaccination
title_fullStr Seroconversion after recombinant Hepatitis B vaccination
title_full_unstemmed Seroconversion after recombinant Hepatitis B vaccination
title_sort seroconversion after recombinant hepatitis b vaccination
publisher Bangladesh Society of Medicine
publishDate 2010
url http://irep.iium.edu.my/87312/1/Seroconversion%20after%20HBV%20vaccination.pdf
http://irep.iium.edu.my/87312/
http://doi.org/10.3329/jom.v11i2.5461
_version_ 1688547782518898688
score 13.211869

Similar Items