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Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain

Introduction: Little is known whether the duration of opioid use influences the concentrations of pro- and anti-inflammatory cytokines. Objectives: This study examined the plasma concentration of pro-inflammatory cytokine, interleukin 6 (IL-6), and anti-inflammatory cytokine, interleukin 10 (IL-1...

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Main Authors: Mizher, Hussam, Zin, Che Suraya, Helal Uddin, A.B.M., Mohamed, Rozilah @ Abdul Hadi, Tan, H Ling, Izzat, Munira
Format: Article
Language:English
Published: Wolters Kluwer Health 2020
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/86960/1/zin_hosam_.pdf
http://irep.iium.edu.my/86960/
https://www.jpbsonline.org/text.asp?2020/12/6/663/299973
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spelling my.iium.irep.869602022-11-07T02:18:51Z http://irep.iium.edu.my/86960/ Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain Mizher, Hussam Zin, Che Suraya Helal Uddin, A.B.M. Mohamed, Rozilah @ Abdul Hadi Tan, H Ling Izzat, Munira RS Pharmacy and materia medica Introduction: Little is known whether the duration of opioid use influences the concentrations of pro- and anti-inflammatory cytokines. Objectives: This study examined the plasma concentration of pro-inflammatory cytokine, interleukin 6 (IL-6), and anti-inflammatory cytokine, interleukin 10 (IL-10), in short-, and long-term opioid users with noncancer pain. Materials and Methods: Adult patients with opioid therapy for noncancer pain were recruited from pain clinics at two tertiary hospital settings in Malaysia between February 2016 and March 2017. They were stratified into short- or long-term users based on opioid prescriptions ≥ 90 days per year. A 10 mL blood sample was taken for the analysis of plasma concentrations of IL-6 and IL-10 and were quantified using a highly sensitive multiplex assay. Results: Of 38 patients recruited, 24% (n = 9/38) and 76% (n = 29/38) were respectively short- and long-term opioid users. Short-term use of opioid was associated with higher levels of IL-6 (mean ± SD, 173.9 ± 13.7 pg/mL) and IL-10 (50 ± 5.8 pg/mL), whereas long-term use of opioids was associated with lower levels (no significant difference) of both cytokines IL6 (125 ± 16.1 pg/mL) and IL10 (41.3 ± 6.7 pg/mL). There was strong correlation between IL-6 and IL-10 within the same group (r² = 0.72, P < 0.05) and (r² = 0.76, P < 0.05) for short- and long-term users, respectively. Conclusion: The duration of opioid use may modulate the level of pro-inflammatory cytokines in which it was higher in short-term use and lower in long-term use, but the effect of pain relief was similar as both cytokines were well correlated Wolters Kluwer Health 2020-11-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/86960/1/zin_hosam_.pdf Mizher, Hussam and Zin, Che Suraya and Helal Uddin, A.B.M. and Mohamed, Rozilah @ Abdul Hadi and Tan, H Ling and Izzat, Munira (2020) Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain. Journal of Pharmacy and Bioallied Sciences, 12 (6). pp. 663-666. ISSN 0976-4879 E-ISSN 0975-7406 https://www.jpbsonline.org/text.asp?2020/12/6/663/299973
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Mizher, Hussam
Zin, Che Suraya
Helal Uddin, A.B.M.
Mohamed, Rozilah @ Abdul Hadi
Tan, H Ling
Izzat, Munira
Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain
description Introduction: Little is known whether the duration of opioid use influences the concentrations of pro- and anti-inflammatory cytokines. Objectives: This study examined the plasma concentration of pro-inflammatory cytokine, interleukin 6 (IL-6), and anti-inflammatory cytokine, interleukin 10 (IL-10), in short-, and long-term opioid users with noncancer pain. Materials and Methods: Adult patients with opioid therapy for noncancer pain were recruited from pain clinics at two tertiary hospital settings in Malaysia between February 2016 and March 2017. They were stratified into short- or long-term users based on opioid prescriptions ≥ 90 days per year. A 10 mL blood sample was taken for the analysis of plasma concentrations of IL-6 and IL-10 and were quantified using a highly sensitive multiplex assay. Results: Of 38 patients recruited, 24% (n = 9/38) and 76% (n = 29/38) were respectively short- and long-term opioid users. Short-term use of opioid was associated with higher levels of IL-6 (mean ± SD, 173.9 ± 13.7 pg/mL) and IL-10 (50 ± 5.8 pg/mL), whereas long-term use of opioids was associated with lower levels (no significant difference) of both cytokines IL6 (125 ± 16.1 pg/mL) and IL10 (41.3 ± 6.7 pg/mL). There was strong correlation between IL-6 and IL-10 within the same group (r² = 0.72, P < 0.05) and (r² = 0.76, P < 0.05) for short- and long-term users, respectively. Conclusion: The duration of opioid use may modulate the level of pro-inflammatory cytokines in which it was higher in short-term use and lower in long-term use, but the effect of pain relief was similar as both cytokines were well correlated
format Article
author Mizher, Hussam
Zin, Che Suraya
Helal Uddin, A.B.M.
Mohamed, Rozilah @ Abdul Hadi
Tan, H Ling
Izzat, Munira
author_facet Mizher, Hussam
Zin, Che Suraya
Helal Uddin, A.B.M.
Mohamed, Rozilah @ Abdul Hadi
Tan, H Ling
Izzat, Munira
author_sort Mizher, Hussam
title Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain
title_short Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain
title_full Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain
title_fullStr Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain
title_full_unstemmed Plasma concentrations of pro-inflammatory cytokine IL-6 and antiinflammatory cytokine IL-10 in short- and long-term opioid users with noncancer pain
title_sort plasma concentrations of pro-inflammatory cytokine il-6 and antiinflammatory cytokine il-10 in short- and long-term opioid users with noncancer pain
publisher Wolters Kluwer Health
publishDate 2020
url http://irep.iium.edu.my/86960/1/zin_hosam_.pdf
http://irep.iium.edu.my/86960/
https://www.jpbsonline.org/text.asp?2020/12/6/663/299973
_version_ 1751535903360155648
score 13.211869

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