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Solanum torvum for hypertension in ‘Kitab al-tibb’: A systematic review on the scientific evidence

Solanum torvum or ‘terung pipit’ is a perennial herb that was mentioned in ‘Kitab al-Tibb’ or ‘Kitab Tibb Pontianak’ for treatment of hypertension. The aim of this study is to conduct systematic review utilizing Science Direct, PubMed and Scopus databases asserting the claim. Search was carried out...

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Main Author: Ismail, Azlini
Format: Conference or Workshop Item
Language:English
English
English
Published: 2020
Subjects:
RM Therapeutics. Pharmacology
RM147 Administration of Drugs and Other Therapeutic Agents
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/86585/13/86585_ICOMMM%20Programme%20Book%202020.pdf
http://irep.iium.edu.my/86585/14/86585_ICOMMM%20Programme%20Schedule%202020.pdf
http://irep.iium.edu.my/86585/15/86585_Solanum%20torvum%20for%20hypertension.pdf
http://irep.iium.edu.my/86585/
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spelling my.iium.irep.865852020-12-30T06:37:28Z http://irep.iium.edu.my/86585/ Solanum torvum for hypertension in ‘Kitab al-tibb’: A systematic review on the scientific evidence Ismail, Azlini RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents RS Pharmacy and materia medica Solanum torvum or ‘terung pipit’ is a perennial herb that was mentioned in ‘Kitab al-Tibb’ or ‘Kitab Tibb Pontianak’ for treatment of hypertension. The aim of this study is to conduct systematic review utilizing Science Direct, PubMed and Scopus databases asserting the claim. Search was carried out without date and language restrictions, and based on combinations of the following keywords; "Solanum torvum", "S. torvum”, "antihypertensive", "antihypertensive", "diuretic", "vasodilation", "ACE inhibitor", "angiotensin converting enzyme inhibitor", and "blood pressure". After systematic search and filtration of the inclusion and exclusion criteria, 17 research articles were included in this review. It was found that the frequently used part of S. torvum in these studies was its fruits. The plausible evidences found include; i) reduction in blood pressure of normotensive and hypertensive rats (induced by high fructose diet), ii) diuretic activity by increasing total urine output and increased sodium excretion in normotensive rats, and iii) significant inhibition on angiotensin-converting enzyme that is responsible for production of Angiotensin II, a potent vasoconstrictor. The isolated active compound found was (E)-2,3- dihydroxycyclopentyl-3- (3′,4′-dihydroxyphenyl) acrylate. In contrast, one article showed contradictory findings whereby S. torvum was reported to induce partial vasoconstriction, and to amplify hypertensive effect in L-NG-Nitro arginine methyl ester (L-NAME)-induced hypertensive rats, an animal model which was deprived from the relaxing factor, nitric oxide. Despite this, the same study reported an increase in total urine output and sodium excretion in L-NAMEinduced hypertensive rats. These discrepancies actually suggest that S. torvum actually works distinctively in different animal models of induced hypertension; thus, there is a need to conduct further study on Spontaneously Hypertensive Rats model to actually mimic the essential hypertension that frequently occurs in humans. Altogether, this review found scientific evidence from modern science supporting the use of S. torvum as mentioned in ‘Kitab al-Tibb’ for hypertension. 2020-12-15 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/86585/13/86585_ICOMMM%20Programme%20Book%202020.pdf application/pdf en http://irep.iium.edu.my/86585/14/86585_ICOMMM%20Programme%20Schedule%202020.pdf application/pdf en http://irep.iium.edu.my/86585/15/86585_Solanum%20torvum%20for%20hypertension.pdf Ismail, Azlini (2020) Solanum torvum for hypertension in ‘Kitab al-tibb’: A systematic review on the scientific evidence. In: International Conference on Malay Medical Manuscript (ICOMMM) 2020, 15th - 16th December 2020, IIUM Kuantan, Pahang, Malaysia.
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic RM Therapeutics. Pharmacology
RM147 Administration of Drugs and Other Therapeutic Agents
RS Pharmacy and materia medica
spellingShingle RM Therapeutics. Pharmacology
RM147 Administration of Drugs and Other Therapeutic Agents
RS Pharmacy and materia medica
Ismail, Azlini
Solanum torvum for hypertension in ‘Kitab al-tibb’: A systematic review on the scientific evidence
description Solanum torvum or ‘terung pipit’ is a perennial herb that was mentioned in ‘Kitab al-Tibb’ or ‘Kitab Tibb Pontianak’ for treatment of hypertension. The aim of this study is to conduct systematic review utilizing Science Direct, PubMed and Scopus databases asserting the claim. Search was carried out without date and language restrictions, and based on combinations of the following keywords; "Solanum torvum", "S. torvum”, "antihypertensive", "antihypertensive", "diuretic", "vasodilation", "ACE inhibitor", "angiotensin converting enzyme inhibitor", and "blood pressure". After systematic search and filtration of the inclusion and exclusion criteria, 17 research articles were included in this review. It was found that the frequently used part of S. torvum in these studies was its fruits. The plausible evidences found include; i) reduction in blood pressure of normotensive and hypertensive rats (induced by high fructose diet), ii) diuretic activity by increasing total urine output and increased sodium excretion in normotensive rats, and iii) significant inhibition on angiotensin-converting enzyme that is responsible for production of Angiotensin II, a potent vasoconstrictor. The isolated active compound found was (E)-2,3- dihydroxycyclopentyl-3- (3′,4′-dihydroxyphenyl) acrylate. In contrast, one article showed contradictory findings whereby S. torvum was reported to induce partial vasoconstriction, and to amplify hypertensive effect in L-NG-Nitro arginine methyl ester (L-NAME)-induced hypertensive rats, an animal model which was deprived from the relaxing factor, nitric oxide. Despite this, the same study reported an increase in total urine output and sodium excretion in L-NAMEinduced hypertensive rats. These discrepancies actually suggest that S. torvum actually works distinctively in different animal models of induced hypertension; thus, there is a need to conduct further study on Spontaneously Hypertensive Rats model to actually mimic the essential hypertension that frequently occurs in humans. Altogether, this review found scientific evidence from modern science supporting the use of S. torvum as mentioned in ‘Kitab al-Tibb’ for hypertension.
format Conference or Workshop Item
author Ismail, Azlini
author_facet Ismail, Azlini
author_sort Ismail, Azlini
title Solanum torvum for hypertension in ‘Kitab al-tibb’: A systematic review on the scientific evidence
title_short Solanum torvum for hypertension in ‘Kitab al-tibb’: A systematic review on the scientific evidence
title_full Solanum torvum for hypertension in ‘Kitab al-tibb’: A systematic review on the scientific evidence
title_fullStr Solanum torvum for hypertension in ‘Kitab al-tibb’: A systematic review on the scientific evidence
title_full_unstemmed Solanum torvum for hypertension in ‘Kitab al-tibb’: A systematic review on the scientific evidence
title_sort solanum torvum for hypertension in ‘kitab al-tibb’: a systematic review on the scientific evidence
publishDate 2020
url http://irep.iium.edu.my/86585/13/86585_ICOMMM%20Programme%20Book%202020.pdf
http://irep.iium.edu.my/86585/14/86585_ICOMMM%20Programme%20Schedule%202020.pdf
http://irep.iium.edu.my/86585/15/86585_Solanum%20torvum%20for%20hypertension.pdf
http://irep.iium.edu.my/86585/
_version_ 1688547748567056384
score 13.211869

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