Cover Image

Comparison between the effect of GnRH agonist and HCG injection on the luteal phase support in patient undergoing IUI

Intrauterine insemination is amongst the foremost recommended procedures to reinforce the probability of pregnancy in couples with infertility. The success rate of this system depends on numerous factors, one among which is that the quality of the luteal phase which could be due to insufficient prod...

Full description

Saved in:
Bibliographic Details
Main Authors: Mohammed, Zahraa Ali, Selman, Mohammad Oda, Jawad, Mufeeda Ali, Faisal, Ghasak Ghazi, Mohammad, Ahmad
Format: Article
Language:English
English
Published: 2020
Subjects:
RB Pathology
RG Gynecology and obstetrics
Online Access:http://irep.iium.edu.my/86406/1/XD20_1244_Ghassak_Ghazi_Faisal_Malaysia%20%281%29.pdf
http://irep.iium.edu.my/86406/7/86406%20acceptance.pdf
http://irep.iium.edu.my/86406/
http://www.jidmr.com/journal/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.86406
record_format dspace
spelling my.iium.irep.864062020-12-17T08:43:35Z http://irep.iium.edu.my/86406/ Comparison between the effect of GnRH agonist and HCG injection on the luteal phase support in patient undergoing IUI Mohammed, Zahraa Ali Selman, Mohammad Oda Jawad, Mufeeda Ali Faisal, Ghasak Ghazi Mohammad, Ahmad RB Pathology RG Gynecology and obstetrics Intrauterine insemination is amongst the foremost recommended procedures to reinforce the probability of pregnancy in couples with infertility. The success rate of this system depends on numerous factors, one among which is that the quality of the luteal phase which could be due to insufficient production of progesterone. To study the impact of luteal phase GnRH agonist versus HCG supplementation on pregnancy rates in females undergoing intrauterine insemination. This study was performed on random 40 infertile couples. Basal hormones measurement of FSH, LH, E2 and progesterone was done before undergoing ovarian stimulation by letrozole or clomiphene citrate. In the mid cycle transvaginal ultrasound was done to measure the dominate follicle/ s and endometrial thickness (ET). Assessment of progesterone and E2 was done on the trigger day. Triggering of ovulation was done by the HCG injection (5000IU). IUI for all females included in the study then they were divided into two groups of 20. Group A were supplemented with GnRH agonist injections (0.1 mg) on day 9,10,11,12 post IUI plus progesterone suppositories 400 mg for 14 days while group B were supplemented with HCG injections 1500IU on day 1, 4, 7 post IUI plus progesterone suppositories 400 mg for 14 days. Then Progesterone level was re measured at day 21 of the cycle. Chemical pregnancy rate was done and recorded. The hormonal levels showed no significant difference in baseline serum FSH, LH and estradiol (E2) (P > 0.05); however, there was significant difference in mean serum baseline progesterone between protocol groups (p= 0.024); additionally, there was no significant difference in mean serum estradiol (E2) and progesterone at day 12 (p> 0.05), but the difference in mean serum progesterone at day 21 was highly significant (p < 0.001); its level was highest in group B than A. The pregnancy rate of infertile women in groupA (who used GnRH as supportive to luteal phase) was higher (40.0 %).Conclusions: Luteal phase support by GnRH injection (Decapeptyl 0.1mg) significantly increased pregnancy rate in infertile females undergoing intrauterine insemination compared to HCG injection (1500IU) in spite of significant elevation in progesterone hormone at 21the day in HCG group. 2020 Article PeerReviewed application/pdf en http://irep.iium.edu.my/86406/1/XD20_1244_Ghassak_Ghazi_Faisal_Malaysia%20%281%29.pdf application/pdf en http://irep.iium.edu.my/86406/7/86406%20acceptance.pdf Mohammed, Zahraa Ali and Selman, Mohammad Oda and Jawad, Mufeeda Ali and Faisal, Ghasak Ghazi and Mohammad, Ahmad (2020) Comparison between the effect of GnRH agonist and HCG injection on the luteal phase support in patient undergoing IUI. Journal of international dental and medical research, 13 (4). ISSN 1309-100X (In Press) http://www.jidmr.com/journal/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RB Pathology
RG Gynecology and obstetrics
spellingShingle RB Pathology
RG Gynecology and obstetrics
Mohammed, Zahraa Ali
Selman, Mohammad Oda
Jawad, Mufeeda Ali
Faisal, Ghasak Ghazi
Mohammad, Ahmad
Comparison between the effect of GnRH agonist and HCG injection on the luteal phase support in patient undergoing IUI
description Intrauterine insemination is amongst the foremost recommended procedures to reinforce the probability of pregnancy in couples with infertility. The success rate of this system depends on numerous factors, one among which is that the quality of the luteal phase which could be due to insufficient production of progesterone. To study the impact of luteal phase GnRH agonist versus HCG supplementation on pregnancy rates in females undergoing intrauterine insemination. This study was performed on random 40 infertile couples. Basal hormones measurement of FSH, LH, E2 and progesterone was done before undergoing ovarian stimulation by letrozole or clomiphene citrate. In the mid cycle transvaginal ultrasound was done to measure the dominate follicle/ s and endometrial thickness (ET). Assessment of progesterone and E2 was done on the trigger day. Triggering of ovulation was done by the HCG injection (5000IU). IUI for all females included in the study then they were divided into two groups of 20. Group A were supplemented with GnRH agonist injections (0.1 mg) on day 9,10,11,12 post IUI plus progesterone suppositories 400 mg for 14 days while group B were supplemented with HCG injections 1500IU on day 1, 4, 7 post IUI plus progesterone suppositories 400 mg for 14 days. Then Progesterone level was re measured at day 21 of the cycle. Chemical pregnancy rate was done and recorded. The hormonal levels showed no significant difference in baseline serum FSH, LH and estradiol (E2) (P > 0.05); however, there was significant difference in mean serum baseline progesterone between protocol groups (p= 0.024); additionally, there was no significant difference in mean serum estradiol (E2) and progesterone at day 12 (p> 0.05), but the difference in mean serum progesterone at day 21 was highly significant (p < 0.001); its level was highest in group B than A. The pregnancy rate of infertile women in groupA (who used GnRH as supportive to luteal phase) was higher (40.0 %).Conclusions: Luteal phase support by GnRH injection (Decapeptyl 0.1mg) significantly increased pregnancy rate in infertile females undergoing intrauterine insemination compared to HCG injection (1500IU) in spite of significant elevation in progesterone hormone at 21the day in HCG group.
format Article
author Mohammed, Zahraa Ali
Selman, Mohammad Oda
Jawad, Mufeeda Ali
Faisal, Ghasak Ghazi
Mohammad, Ahmad
author_facet Mohammed, Zahraa Ali
Selman, Mohammad Oda
Jawad, Mufeeda Ali
Faisal, Ghasak Ghazi
Mohammad, Ahmad
author_sort Mohammed, Zahraa Ali
title Comparison between the effect of GnRH agonist and HCG injection on the luteal phase support in patient undergoing IUI
title_short Comparison between the effect of GnRH agonist and HCG injection on the luteal phase support in patient undergoing IUI
title_full Comparison between the effect of GnRH agonist and HCG injection on the luteal phase support in patient undergoing IUI
title_fullStr Comparison between the effect of GnRH agonist and HCG injection on the luteal phase support in patient undergoing IUI
title_full_unstemmed Comparison between the effect of GnRH agonist and HCG injection on the luteal phase support in patient undergoing IUI
title_sort comparison between the effect of gnrh agonist and hcg injection on the luteal phase support in patient undergoing iui
publishDate 2020
url http://irep.iium.edu.my/86406/1/XD20_1244_Ghassak_Ghazi_Faisal_Malaysia%20%281%29.pdf
http://irep.iium.edu.my/86406/7/86406%20acceptance.pdf
http://irep.iium.edu.my/86406/
http://www.jidmr.com/journal/
_version_ 1687393157224857600
score 13.211869

Similar Items