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A review on oxidative stress, diabetic complications, and the roles of honey polyphenols

Despite the availability of various antidiabetic drugs, diabetes mellitus (DM) remains one of the world’s most prevalent chronic diseases and is a global burden. Hyperglycaemia, a characteristic of type 2 diabetes mellitus (T2DM), substantially leads to the generation of reactive oxygen species (ROS...

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Main Authors:	Pasupuleti, Visweswara Rao, Arigela, Chandra Sekhar, Gan, Siew Hua, Kuttulebbai Naina Mohamed Salam, Sirajudeen, Krishnan, Kumara Thevan, Abdul Rahman, Nurhanan, Jeffree, Mohammad Saffree
Format:	Article
Language:	English English
Published:	Hindawi Publishers 2020
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/85338/1/honey%20review%20paper%2024.11.2020%20KNSS.pdf http://irep.iium.edu.my/85338/7/85338_A%20review%20on%20oxidative%20stress%2C%20diabetic%20complications_scopus.pdf http://irep.iium.edu.my/85338/ https://www.hindawi.com/journals/omcl/2020/8878172/ https://doi.org/10.1155/2020/8878172
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spelling	my.iium.irep.853382021-01-16T08:19:11Z http://irep.iium.edu.my/85338/ A review on oxidative stress, diabetic complications, and the roles of honey polyphenols Pasupuleti, Visweswara Rao Arigela, Chandra Sekhar Gan, Siew Hua Kuttulebbai Naina Mohamed Salam, Sirajudeen Krishnan, Kumara Thevan Abdul Rahman, Nurhanan Jeffree, Mohammad Saffree R Medicine (General) Despite the availability of various antidiabetic drugs, diabetes mellitus (DM) remains one of the world’s most prevalent chronic diseases and is a global burden. Hyperglycaemia, a characteristic of type 2 diabetes mellitus (T2DM), substantially leads to the generation of reactive oxygen species (ROS), triggering oxidative stress as well as numerous cellular and molecular modifications such as mitochondrial dysfunction affecting normal physiological functions in the body. In mitochondrial-mediated processes, oxidative pathways play an important role, although the responsible molecular mechanisms remain unclear. The impaired mitochondrial function is evidenced by insulin insensitivity in various cell types. In addition, the roles of master antioxidant pathway nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)/antioxidant response elements (ARE) are being deciphered to explain various molecular pathways involved in diabetes. Dietary factors are known to influence diabetes, and many natural dietary factors have been studied to improve diabetes. Honey is primarily rich in carbohydrates and is also abundant in flavonoids and phenolic acids; thus, it is a promising therapeutic antioxidant for various disorders. Various research has indicated that honey has strong wound-healing properties and has antibacterial, anti-inflammatory, antifungal, and antiviral effects; thus, it is a promising antidiabetic agent. The potential antidiabetic mechanisms of honey were proposed based on its major constituents. This review focuses on the various prospects of using honey as an antidiabetic agent and the potential insights. Hindawi Publishers 2020-11-23 Article PeerReviewed application/pdf en http://irep.iium.edu.my/85338/1/honey%20review%20paper%2024.11.2020%20KNSS.pdf application/pdf en http://irep.iium.edu.my/85338/7/85338_A%20review%20on%20oxidative%20stress%2C%20diabetic%20complications_scopus.pdf Pasupuleti, Visweswara Rao and Arigela, Chandra Sekhar and Gan, Siew Hua and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Krishnan, Kumara Thevan and Abdul Rahman, Nurhanan and Jeffree, Mohammad Saffree (2020) A review on oxidative stress, diabetic complications, and the roles of honey polyphenols. Oxidative Medicine and Cellular Longevity, 2020. pp. 1-16. ISSN 1942-0994 https://www.hindawi.com/journals/omcl/2020/8878172/ https://doi.org/10.1155/2020/8878172
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Pasupuleti, Visweswara Rao Arigela, Chandra Sekhar Gan, Siew Hua Kuttulebbai Naina Mohamed Salam, Sirajudeen Krishnan, Kumara Thevan Abdul Rahman, Nurhanan Jeffree, Mohammad Saffree A review on oxidative stress, diabetic complications, and the roles of honey polyphenols
description	Despite the availability of various antidiabetic drugs, diabetes mellitus (DM) remains one of the world’s most prevalent chronic diseases and is a global burden. Hyperglycaemia, a characteristic of type 2 diabetes mellitus (T2DM), substantially leads to the generation of reactive oxygen species (ROS), triggering oxidative stress as well as numerous cellular and molecular modifications such as mitochondrial dysfunction affecting normal physiological functions in the body. In mitochondrial-mediated processes, oxidative pathways play an important role, although the responsible molecular mechanisms remain unclear. The impaired mitochondrial function is evidenced by insulin insensitivity in various cell types. In addition, the roles of master antioxidant pathway nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)/antioxidant response elements (ARE) are being deciphered to explain various molecular pathways involved in diabetes. Dietary factors are known to influence diabetes, and many natural dietary factors have been studied to improve diabetes. Honey is primarily rich in carbohydrates and is also abundant in flavonoids and phenolic acids; thus, it is a promising therapeutic antioxidant for various disorders. Various research has indicated that honey has strong wound-healing properties and has antibacterial, anti-inflammatory, antifungal, and antiviral effects; thus, it is a promising antidiabetic agent. The potential antidiabetic mechanisms of honey were proposed based on its major constituents. This review focuses on the various prospects of using honey as an antidiabetic agent and the potential insights.
format	Article
author	Pasupuleti, Visweswara Rao Arigela, Chandra Sekhar Gan, Siew Hua Kuttulebbai Naina Mohamed Salam, Sirajudeen Krishnan, Kumara Thevan Abdul Rahman, Nurhanan Jeffree, Mohammad Saffree
author_facet	Pasupuleti, Visweswara Rao Arigela, Chandra Sekhar Gan, Siew Hua Kuttulebbai Naina Mohamed Salam, Sirajudeen Krishnan, Kumara Thevan Abdul Rahman, Nurhanan Jeffree, Mohammad Saffree
author_sort	Pasupuleti, Visweswara Rao
title	A review on oxidative stress, diabetic complications, and the roles of honey polyphenols
title_short	A review on oxidative stress, diabetic complications, and the roles of honey polyphenols
title_full	A review on oxidative stress, diabetic complications, and the roles of honey polyphenols
title_fullStr	A review on oxidative stress, diabetic complications, and the roles of honey polyphenols
title_full_unstemmed	A review on oxidative stress, diabetic complications, and the roles of honey polyphenols
title_sort	review on oxidative stress, diabetic complications, and the roles of honey polyphenols
publisher	Hindawi Publishers
publishDate	2020
url	http://irep.iium.edu.my/85338/1/honey%20review%20paper%2024.11.2020%20KNSS.pdf http://irep.iium.edu.my/85338/7/85338_A%20review%20on%20oxidative%20stress%2C%20diabetic%20complications_scopus.pdf http://irep.iium.edu.my/85338/ https://www.hindawi.com/journals/omcl/2020/8878172/ https://doi.org/10.1155/2020/8878172
_version_	1690370745942671360
score	13.211869

A review on oxidative stress, diabetic complications, and the roles of honey polyphenols

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