Cover Image

Systolic Time Interval (STI) in hypothyroid patients receiving high dose L-Thyroxine

Introduction: Systolic Time Interval (STI) is a simple,noninvasive and precise technique to assess left ventricular (LV) function. It measures aortic Pre-Ejection Period (PEP) over Left Ventricular Ejection Time (LVET) from echocardiogram. Thyrotoxicosis will enhance LV function and cause reduction...

Full description

Saved in:
Bibliographic Details
Main Authors: Zakaria, Nurul Aulia, Pasi, Hafizah, Shahar, Mohammad Arif
Format: Article
Language:English
Published: Kulliyyah of Medicine, International Islamic University Malaysia 2020
Subjects:
RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
Online Access:http://irep.iium.edu.my/85106/1/582-Manuscript-1714-1-10-20200115.pdf
http://irep.iium.edu.my/85106/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/582/354
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.85106
record_format dspace
spelling my.iium.irep.851062020-12-01T01:38:16Z http://irep.iium.edu.my/85106/ Systolic Time Interval (STI) in hypothyroid patients receiving high dose L-Thyroxine Zakaria, Nurul Aulia Pasi, Hafizah Shahar, Mohammad Arif RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology Introduction: Systolic Time Interval (STI) is a simple,noninvasive and precise technique to assess left ventricular (LV) function. It measures aortic Pre-Ejection Period (PEP) over Left Ventricular Ejection Time (LVET) from echocardiogram. Thyrotoxicosis will enhance LV function and cause reduction of STI. This study was perform to measure the changes of STI after administration of high dose L-thyroxine and to determine the correlation between high dose L-thyroxine administration and STI. Materials and Method: A Total of 22 patients were screened. Those with cardiac diseases and high Framingham risk score were excluded. Nine patients were started on high dose L-thyroxine (7x their usual dose) once a week during the month of Ramadan.Thyroid hormones ( T3,T4,TSH)Â and STI (PEP/LVET) were measured at baseline and within 24 hrs after high dose L-thyroxine ingestion. Results: All patients have normal thyroid hormones level and normal cardiac function at baseline. The median dose (mcg) of L-thyroxine was 600 (437.5,700) while the median level of fT4 (pmol/L) was 17.43(12.38,20.8). Despite the significant increment of fT4 after L- thyroxine ingestion [baseline 13.21(8.19,14.63) vs high dose 17.43(12.38,22.55) p; 0.011] there was no significant change in STI [baseline 0.3(0.2,0.4) vs high dose 0.28(0.26,0.45) p; 0.513]. There was no correlation found between the dose of L- thyroxine and STI (r=0.244 , p;0.526). Conclusion: Administration of high dose L- thyroxine did not significantly alter STI despite significant increment of fT4 level unlike the naturally occurring thyrotoxicosis.Therefore ‘exogenous’ administration of high dose L-thyroxine is cardiac safe. Kulliyyah of Medicine, International Islamic University Malaysia 2020-01-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/85106/1/582-Manuscript-1714-1-10-20200115.pdf Zakaria, Nurul Aulia and Pasi, Hafizah and Shahar, Mohammad Arif (2020) Systolic Time Interval (STI) in hypothyroid patients receiving high dose L-Thyroxine. IIUM Medical Journal Malaysia (IMJM), 18 (2 Supplementary Issue No 2). p. 17. ISSN 1823-4631 E-ISSN 2735-2285 https://journals.iium.edu.my/kom/index.php/imjm/article/view/582/354 10.31436/imjm.v18i2.582
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
spellingShingle RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
Zakaria, Nurul Aulia
Pasi, Hafizah
Shahar, Mohammad Arif
Systolic Time Interval (STI) in hypothyroid patients receiving high dose L-Thyroxine
description Introduction: Systolic Time Interval (STI) is a simple,noninvasive and precise technique to assess left ventricular (LV) function. It measures aortic Pre-Ejection Period (PEP) over Left Ventricular Ejection Time (LVET) from echocardiogram. Thyrotoxicosis will enhance LV function and cause reduction of STI. This study was perform to measure the changes of STI after administration of high dose L-thyroxine and to determine the correlation between high dose L-thyroxine administration and STI. Materials and Method: A Total of 22 patients were screened. Those with cardiac diseases and high Framingham risk score were excluded. Nine patients were started on high dose L-thyroxine (7x their usual dose) once a week during the month of Ramadan.Thyroid hormones ( T3,T4,TSH)Â and STI (PEP/LVET) were measured at baseline and within 24 hrs after high dose L-thyroxine ingestion. Results: All patients have normal thyroid hormones level and normal cardiac function at baseline. The median dose (mcg) of L-thyroxine was 600 (437.5,700) while the median level of fT4 (pmol/L) was 17.43(12.38,20.8). Despite the significant increment of fT4 after L- thyroxine ingestion [baseline 13.21(8.19,14.63) vs high dose 17.43(12.38,22.55) p; 0.011] there was no significant change in STI [baseline 0.3(0.2,0.4) vs high dose 0.28(0.26,0.45) p; 0.513]. There was no correlation found between the dose of L- thyroxine and STI (r=0.244 , p;0.526). Conclusion: Administration of high dose L- thyroxine did not significantly alter STI despite significant increment of fT4 level unlike the naturally occurring thyrotoxicosis.Therefore ‘exogenous’ administration of high dose L-thyroxine is cardiac safe.
format Article
author Zakaria, Nurul Aulia
Pasi, Hafizah
Shahar, Mohammad Arif
author_facet Zakaria, Nurul Aulia
Pasi, Hafizah
Shahar, Mohammad Arif
author_sort Zakaria, Nurul Aulia
title Systolic Time Interval (STI) in hypothyroid patients receiving high dose L-Thyroxine
title_short Systolic Time Interval (STI) in hypothyroid patients receiving high dose L-Thyroxine
title_full Systolic Time Interval (STI) in hypothyroid patients receiving high dose L-Thyroxine
title_fullStr Systolic Time Interval (STI) in hypothyroid patients receiving high dose L-Thyroxine
title_full_unstemmed Systolic Time Interval (STI) in hypothyroid patients receiving high dose L-Thyroxine
title_sort systolic time interval (sti) in hypothyroid patients receiving high dose l-thyroxine
publisher Kulliyyah of Medicine, International Islamic University Malaysia
publishDate 2020
url http://irep.iium.edu.my/85106/1/582-Manuscript-1714-1-10-20200115.pdf
http://irep.iium.edu.my/85106/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/582/354
_version_ 1685578549592850432
score 13.211869

Similar Items