Potentiation of testicular cytotoxicity by the alkyltransferase inhibitor O6 benzylguanine and the 5-fluorouracil/N-(2-chloroethyl)-N-nitrosourea molecular combination, B.4152
Alkylating agents are a group of compounds that have a cytotoxic effect due to their ability to form adducts with DNA. Cells possess the ability to repair this damage via an enzyme, O6-alkylguanine-DNA alkyltransferase (AGT). To study the effect of inhibiting this repair mechanism upon testicular cy...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1996
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/8409/1/Reprod_Tox_1996_Suzanah.pdf http://irep.iium.edu.my/8409/ http://www.journals.elsevier.com/reproductive-toxicology/ |
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