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Poly(trimethylene carbonate-co-caprolactone): An emerging drug delivery nanosystem in pharmaceutics

As conventional drug delivery system is being improved rapidly by target-based drug delivery system, finding suitable Drug Delivery System (DDS) for new drugs remains a challenge. Although there are many drug delivery vehicles in existence, a significant improvement is required to some DDS such as f...

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Main Authors: Hossain, Md. Sanower, Mohamed, Farahidah, Mohd Shafri, Mohd Affendi
Format: Article
Language:English
Published: Techno-Press, Ltd. 2020
Subjects:
RS Pharmacy and materia medica
RS192 Materia Medica-Pharmaceutical Technology
Online Access:http://irep.iium.edu.my/83949/1/83949_Poly%28trimethylene%20carbonate-co-caprolactone%29.pdf
http://irep.iium.edu.my/83949/
http://dx.doi.org/10.12989/bme.2020.5.1.065
http://dx.doi.org/10.12989/bme.2020.5.1.065
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spelling my.iium.irep.839492020-11-02T08:16:23Z http://irep.iium.edu.my/83949/ Poly(trimethylene carbonate-co-caprolactone): An emerging drug delivery nanosystem in pharmaceutics Hossain, Md. Sanower Mohamed, Farahidah Mohd Shafri, Mohd Affendi RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology As conventional drug delivery system is being improved rapidly by target-based drug delivery system, finding suitable Drug Delivery System (DDS) for new drugs remains a challenge. Although there are many drug delivery vehicles in existence, a significant improvement is required to some DDS such as for local, implant-based treatments used for musculoskeletal infections. Many polymers have been considered for providing the improvement in DDS. Synthetic polymer, for example, has gained popularity for broad-spectrum physicochemical and mechanical properties. This article reviews the biomedical applications of poly(TriMethylene Carbonate-co-Caprolactone) (PTMCC), which has attracted attention due to its biocompatibility, biodegradability and rubber-like properties. Its synthesis, physical properties, and degradation are also discussed here. Although it is relatively new in biomedical applications, it is readily usable for the fabrication of differing format of DDS of superior mechanical strength and degradation properties. The use of PTMCC is expected to increase in coming years as more is revealed about its potentials. Techno-Press, Ltd. 2020-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/83949/1/83949_Poly%28trimethylene%20carbonate-co-caprolactone%29.pdf Hossain, Md. Sanower and Mohamed, Farahidah and Mohd Shafri, Mohd Affendi (2020) Poly(trimethylene carbonate-co-caprolactone): An emerging drug delivery nanosystem in pharmaceutics. Biomaterials and Biomechanics in Bioengineering,, 5 (1). pp. 65-86. ISSN 2465-9835 E-ISSN 2465-9959 http://dx.doi.org/10.12989/bme.2020.5.1.065 http://dx.doi.org/10.12989/bme.2020.5.1.065
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RS Pharmacy and materia medica
RS192 Materia Medica-Pharmaceutical Technology
spellingShingle RS Pharmacy and materia medica
RS192 Materia Medica-Pharmaceutical Technology
Hossain, Md. Sanower
Mohamed, Farahidah
Mohd Shafri, Mohd Affendi
Poly(trimethylene carbonate-co-caprolactone): An emerging drug delivery nanosystem in pharmaceutics
description As conventional drug delivery system is being improved rapidly by target-based drug delivery system, finding suitable Drug Delivery System (DDS) for new drugs remains a challenge. Although there are many drug delivery vehicles in existence, a significant improvement is required to some DDS such as for local, implant-based treatments used for musculoskeletal infections. Many polymers have been considered for providing the improvement in DDS. Synthetic polymer, for example, has gained popularity for broad-spectrum physicochemical and mechanical properties. This article reviews the biomedical applications of poly(TriMethylene Carbonate-co-Caprolactone) (PTMCC), which has attracted attention due to its biocompatibility, biodegradability and rubber-like properties. Its synthesis, physical properties, and degradation are also discussed here. Although it is relatively new in biomedical applications, it is readily usable for the fabrication of differing format of DDS of superior mechanical strength and degradation properties. The use of PTMCC is expected to increase in coming years as more is revealed about its potentials.
format Article
author Hossain, Md. Sanower
Mohamed, Farahidah
Mohd Shafri, Mohd Affendi
author_facet Hossain, Md. Sanower
Mohamed, Farahidah
Mohd Shafri, Mohd Affendi
author_sort Hossain, Md. Sanower
title Poly(trimethylene carbonate-co-caprolactone): An emerging drug delivery nanosystem in pharmaceutics
title_short Poly(trimethylene carbonate-co-caprolactone): An emerging drug delivery nanosystem in pharmaceutics
title_full Poly(trimethylene carbonate-co-caprolactone): An emerging drug delivery nanosystem in pharmaceutics
title_fullStr Poly(trimethylene carbonate-co-caprolactone): An emerging drug delivery nanosystem in pharmaceutics
title_full_unstemmed Poly(trimethylene carbonate-co-caprolactone): An emerging drug delivery nanosystem in pharmaceutics
title_sort poly(trimethylene carbonate-co-caprolactone): an emerging drug delivery nanosystem in pharmaceutics
publisher Techno-Press, Ltd.
publishDate 2020
url http://irep.iium.edu.my/83949/1/83949_Poly%28trimethylene%20carbonate-co-caprolactone%29.pdf
http://irep.iium.edu.my/83949/
http://dx.doi.org/10.12989/bme.2020.5.1.065
http://dx.doi.org/10.12989/bme.2020.5.1.065
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score 13.211869

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