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Chronic low dose organic arsenic induced liver structural damage

Over the decades, organic arsenic has been thought to be less toxic than inorganic arsenic. Monosodium methylarsonate (MSMA) is a potent organoarsenical herbicide that is still being used in most Asian countries, even though in some countries the used has been restricted. Other organic studies repor...

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Main Authors: Saharudin, Shahida, Abdullah, Nor Zamzila, A.Talib, Norlelawati, Ab Rahman, Jamalludin, Buyong, Zunariah
Format: Conference or Workshop Item
Language:English
English
English
Published: 2019
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/83929/1/Abstract%2028thSCMSM%20Shahida%20Chronic%20Low%20Dose%20Organic%20Arsenic%20Induced%20Liver%20Structural%20Damage.pdf
http://irep.iium.edu.my/83929/7/National%20-%202019%20-%20Oral%20presentation%2028th%20SCMSM%20drshahida%20%281%29.pdf
http://irep.iium.edu.my/83929/8/SCMSM%202019%20supporting%20documents.pdf
http://irep.iium.edu.my/83929/
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spelling my.iium.irep.839292020-11-02T03:43:29Z http://irep.iium.edu.my/83929/ Chronic low dose organic arsenic induced liver structural damage Saharudin, Shahida Abdullah, Nor Zamzila A.Talib, Norlelawati Ab Rahman, Jamalludin Buyong, Zunariah R Medicine (General) Over the decades, organic arsenic has been thought to be less toxic than inorganic arsenic. Monosodium methylarsonate (MSMA) is a potent organoarsenical herbicide that is still being used in most Asian countries, even though in some countries the used has been restricted. Other organic studies reported the effects mainly on the gastrointestinal system. However, the evidence on the severity of it to the liver is still insufficient. The study objective was to investigate the effect of organic arsenic (MSMA) exposure on hepatocytes and liver sinusoidal endothelial cells (LSEC). Rats were exposed to MSMA at 63.20 mg/kg daily for 6 months duration through oral gavage daily. Control rats received distilled water ad libitum. At the end of the duration, they were sacrificed and underwent liver perfusion for tissue preservation. Liver tissue was prepared for light microscopy, scanning and transmission electron microscopy. Histopathological and ultrastructural comparison between control and treated rats were qualitatively described. Histopathological and ultrastructurally, MSMA has caused necrotic and apoptotic changes of the liver with a reduction of organelles in hepatocytes and capillarization of LSEC. Chronic low dose organic arsenic exposure showed evidence of toxicity to hepatocytes. Interestingly, LSEC demonstrated survival accommodation. 2019-12-18 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/83929/1/Abstract%2028thSCMSM%20Shahida%20Chronic%20Low%20Dose%20Organic%20Arsenic%20Induced%20Liver%20Structural%20Damage.pdf application/pdf en http://irep.iium.edu.my/83929/7/National%20-%202019%20-%20Oral%20presentation%2028th%20SCMSM%20drshahida%20%281%29.pdf application/pdf en http://irep.iium.edu.my/83929/8/SCMSM%202019%20supporting%20documents.pdf Saharudin, Shahida and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Buyong, Zunariah (2019) Chronic low dose organic arsenic induced liver structural damage. In: 28th Scientific Conference of the Microscopy Society Malaysia 2019, 18th - 20th December 2019, Swiss Garden Beach Resort, Kuantan, Pahang. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Saharudin, Shahida
Abdullah, Nor Zamzila
A.Talib, Norlelawati
Ab Rahman, Jamalludin
Buyong, Zunariah
Chronic low dose organic arsenic induced liver structural damage
description Over the decades, organic arsenic has been thought to be less toxic than inorganic arsenic. Monosodium methylarsonate (MSMA) is a potent organoarsenical herbicide that is still being used in most Asian countries, even though in some countries the used has been restricted. Other organic studies reported the effects mainly on the gastrointestinal system. However, the evidence on the severity of it to the liver is still insufficient. The study objective was to investigate the effect of organic arsenic (MSMA) exposure on hepatocytes and liver sinusoidal endothelial cells (LSEC). Rats were exposed to MSMA at 63.20 mg/kg daily for 6 months duration through oral gavage daily. Control rats received distilled water ad libitum. At the end of the duration, they were sacrificed and underwent liver perfusion for tissue preservation. Liver tissue was prepared for light microscopy, scanning and transmission electron microscopy. Histopathological and ultrastructural comparison between control and treated rats were qualitatively described. Histopathological and ultrastructurally, MSMA has caused necrotic and apoptotic changes of the liver with a reduction of organelles in hepatocytes and capillarization of LSEC. Chronic low dose organic arsenic exposure showed evidence of toxicity to hepatocytes. Interestingly, LSEC demonstrated survival accommodation.
format Conference or Workshop Item
author Saharudin, Shahida
Abdullah, Nor Zamzila
A.Talib, Norlelawati
Ab Rahman, Jamalludin
Buyong, Zunariah
author_facet Saharudin, Shahida
Abdullah, Nor Zamzila
A.Talib, Norlelawati
Ab Rahman, Jamalludin
Buyong, Zunariah
author_sort Saharudin, Shahida
title Chronic low dose organic arsenic induced liver structural damage
title_short Chronic low dose organic arsenic induced liver structural damage
title_full Chronic low dose organic arsenic induced liver structural damage
title_fullStr Chronic low dose organic arsenic induced liver structural damage
title_full_unstemmed Chronic low dose organic arsenic induced liver structural damage
title_sort chronic low dose organic arsenic induced liver structural damage
publishDate 2019
url http://irep.iium.edu.my/83929/1/Abstract%2028thSCMSM%20Shahida%20Chronic%20Low%20Dose%20Organic%20Arsenic%20Induced%20Liver%20Structural%20Damage.pdf
http://irep.iium.edu.my/83929/7/National%20-%202019%20-%20Oral%20presentation%2028th%20SCMSM%20drshahida%20%281%29.pdf
http://irep.iium.edu.my/83929/8/SCMSM%202019%20supporting%20documents.pdf
http://irep.iium.edu.my/83929/
_version_ 1683230302753783808
score 13.211869

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