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Chemical constituents and bioactivities of Garcinia malaccensis Hk.f

Garcinia malaccensis Hk.f (Guttiferae) is closely resembled to G. mangostana and G. hombroniana. The genus of Garcinia, especially Garcinia mangostana is well known as a medicinal plant in South-east Asia and is used in traditional medicine. The paper reported the chemical constituents of the stemb...

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Main Authors:	Bakhtiar, M. Taher, Darnis, Deny Susanti, Rezali, Mohd Fazlin, Ahmad Zohri, Farah Syahidah, Solachuddin Jauhari, Arief Ichwan, Alkhamaiseh, Suhaib Ibrahim, Ahmad, Farediah
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/8296/1/Chemical_constituents.pdf http://irep.iium.edu.my/8296/ http://www.icnp2011.upm.edu.my/
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spelling	my.iium.irep.82962011-12-29T10:20:51Z http://irep.iium.edu.my/8296/ Chemical constituents and bioactivities of Garcinia malaccensis Hk.f Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Ahmad Zohri, Farah Syahidah Solachuddin Jauhari, Arief Ichwan Alkhamaiseh, Suhaib Ibrahim Ahmad, Farediah RS Pharmacy and materia medica Garcinia malaccensis Hk.f (Guttiferae) is closely resembled to G. mangostana and G. hombroniana. The genus of Garcinia, especially Garcinia mangostana is well known as a medicinal plant in South-east Asia and is used in traditional medicine. The paper reported the chemical constituents of the stembark of Garcinia malaccensis together with cytotoxic, antimicrobial and antioxidant activities. Purification and structure elucidation were carried out by chromatographic and spectroscopic techniques, respectively. MTT and trypan blue exclusion methods were performed to study the cytotoxic activity. Antibacterial activity was conducted by disc diffusion and microdilution methods, whereas antioxidant activities were done by ferric thiocyanate method and DPPH radical scavenging. The phytochemical study led to the isolation of -mangostin and cycloart-24-en-3-ol. -Mangostin exhibited cytotoxic activity against HSC-3 cells with an IC50 of 0.33 M. β- and α-mangostin showed activity against K562 cells with IC50 of 0.40 M and 0.48 M, respectively. -Mangostin was active against Gram-positive bacteria, Staphylococcus aureus and Bacilus anthracis with inhibition zone and MIC value of (19 mm; 0.025 mg/mL) and (20 mm; 0.013 mg/mL), respectively. In antioxidant assay, -mangostin exhibited activity as an inhibitor of lipid peroxidation. G. malaccensis presence - and -mangostin and cycloart-24-en-3-ol. -Mangostin was found very active against HSC-3 cells and K562. The results suggest that mangostins derivatives have the potential to inhibit the growth of cancer cells by inducing apoptosis. In addition, -and -mangostin was found inhibit the growth of Gram-positive pathogenic bacteria and also showed the activity as an inhibitor of lipid peroxidation. Keywords: Garcinia malaccensis, Guttiferae, apoptosis, antibacterial, antioxidant 2011 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/8296/1/Chemical_constituents.pdf Bakhtiar, M. Taher and Darnis, Deny Susanti and Rezali, Mohd Fazlin and Ahmad Zohri, Farah Syahidah and Solachuddin Jauhari, Arief Ichwan and Alkhamaiseh, Suhaib Ibrahim and Ahmad, Farediah (2011) Chemical constituents and bioactivities of Garcinia malaccensis Hk.f. In: International Conference on Natural Products, 14-16 November 2011, Palm garden Resort, Putrajaya, Malaysia. http://www.icnp2011.upm.edu.my/
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Ahmad Zohri, Farah Syahidah Solachuddin Jauhari, Arief Ichwan Alkhamaiseh, Suhaib Ibrahim Ahmad, Farediah Chemical constituents and bioactivities of Garcinia malaccensis Hk.f
description	Garcinia malaccensis Hk.f (Guttiferae) is closely resembled to G. mangostana and G. hombroniana. The genus of Garcinia, especially Garcinia mangostana is well known as a medicinal plant in South-east Asia and is used in traditional medicine. The paper reported the chemical constituents of the stembark of Garcinia malaccensis together with cytotoxic, antimicrobial and antioxidant activities. Purification and structure elucidation were carried out by chromatographic and spectroscopic techniques, respectively. MTT and trypan blue exclusion methods were performed to study the cytotoxic activity. Antibacterial activity was conducted by disc diffusion and microdilution methods, whereas antioxidant activities were done by ferric thiocyanate method and DPPH radical scavenging. The phytochemical study led to the isolation of -mangostin and cycloart-24-en-3-ol. -Mangostin exhibited cytotoxic activity against HSC-3 cells with an IC50 of 0.33 M. β- and α-mangostin showed activity against K562 cells with IC50 of 0.40 M and 0.48 M, respectively. -Mangostin was active against Gram-positive bacteria, Staphylococcus aureus and Bacilus anthracis with inhibition zone and MIC value of (19 mm; 0.025 mg/mL) and (20 mm; 0.013 mg/mL), respectively. In antioxidant assay, -mangostin exhibited activity as an inhibitor of lipid peroxidation. G. malaccensis presence - and -mangostin and cycloart-24-en-3-ol. -Mangostin was found very active against HSC-3 cells and K562. The results suggest that mangostins derivatives have the potential to inhibit the growth of cancer cells by inducing apoptosis. In addition, -and -mangostin was found inhibit the growth of Gram-positive pathogenic bacteria and also showed the activity as an inhibitor of lipid peroxidation. Keywords: Garcinia malaccensis, Guttiferae, apoptosis, antibacterial, antioxidant
format	Conference or Workshop Item
author	Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Ahmad Zohri, Farah Syahidah Solachuddin Jauhari, Arief Ichwan Alkhamaiseh, Suhaib Ibrahim Ahmad, Farediah
author_facet	Bakhtiar, M. Taher Darnis, Deny Susanti Rezali, Mohd Fazlin Ahmad Zohri, Farah Syahidah Solachuddin Jauhari, Arief Ichwan Alkhamaiseh, Suhaib Ibrahim Ahmad, Farediah
author_sort	Bakhtiar, M. Taher
title	Chemical constituents and bioactivities of Garcinia malaccensis Hk.f
title_short	Chemical constituents and bioactivities of Garcinia malaccensis Hk.f
title_full	Chemical constituents and bioactivities of Garcinia malaccensis Hk.f
title_fullStr	Chemical constituents and bioactivities of Garcinia malaccensis Hk.f
title_full_unstemmed	Chemical constituents and bioactivities of Garcinia malaccensis Hk.f
title_sort	chemical constituents and bioactivities of garcinia malaccensis hk.f
publishDate	2011
url	http://irep.iium.edu.my/8296/1/Chemical_constituents.pdf http://irep.iium.edu.my/8296/ http://www.icnp2011.upm.edu.my/
_version_	1643606103407198208
score	13.211869

Chemical constituents and bioactivities of Garcinia malaccensis Hk.f

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