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Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious?

Coronavirus disease 2019 (COVID-19) is highly contagious in symptomatic patients as it is thought to be transmitted through respiratory droplets. However, it is debatable whether asymptomatic COVID-19 patients are contagious due to lack of data. From 1st March to 15th April 2020, a total of 247 COV...

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Main Authors: Wong, Yen Shen, Muhamad, Dzawani, How, Soon Hin, Mohamed, Mohamed Sapian, Mohd Arif, Nasrah, Soh, Tze Vee, Mohd Hashim, Suzana, Abdullah, Norazmi
Format: Article
Language:English
Published: Science and Education Publishing 2020
Subjects:
R Medicine (General)
RC Internal medicine
Online Access:http://irep.iium.edu.my/82935/7/82935_Asymptomatic%20coronavirus%20disease%202019%20%28COVID-19%29%20carriers.pdf
http://irep.iium.edu.my/82935/
http://pubs.sciepub.com/ajidm/8/3/4/
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spelling my.iium.irep.829352020-10-13T03:50:08Z http://irep.iium.edu.my/82935/ Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious? Wong, Yen Shen Muhamad, Dzawani How, Soon Hin Mohamed, Mohamed Sapian Mohd Arif, Nasrah Soh, Tze Vee Mohd Hashim, Suzana Abdullah, Norazmi R Medicine (General) RC Internal medicine Coronavirus disease 2019 (COVID-19) is highly contagious in symptomatic patients as it is thought to be transmitted through respiratory droplets. However, it is debatable whether asymptomatic COVID-19 patients are contagious due to lack of data. From 1st March to 15th April 2020, a total of 247 COVID-19 cases were admitted to Tengku Ampuan Afzan Hospital and 1010 close contacts were identified. We studied the epidemiological and clinical outcomes in asymptomatic subjects, as well as estimated the metrics of disease transmission between asymptomatic, symptomatic, and pneumonia subjects. From a total of 125 asymptomatic subjects, majority (n=116,92.8%) remained asymptomatic upon discharge. Only 9 (7.2%) subjects developed mild symptoms after admission. Seven subjects had abnormal chest radiograph suggestive of pneumonia, and 22 subjects (17.6%) were found to have mild liver impairment. None of the asymptomatic subjects required oxygen support, inotropic support or ICU care during admission. Fifteen second generation COVID-19 cases were found transmitted from the asymptomatic group, with an attack rate of 3.9%, which was statistically significantly lower compared to the symptomatic (7.6%) or pneumonia groups (25.7%, p<0.001). In conclusion, asymptomatic COVID-19 patients show excellent clinical outcome. They are infectious but had a lower transmission risk compared with symptomatic or pneumonia patients. Science and Education Publishing 2020-09-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/82935/7/82935_Asymptomatic%20coronavirus%20disease%202019%20%28COVID-19%29%20carriers.pdf Wong, Yen Shen and Muhamad, Dzawani and How, Soon Hin and Mohamed, Mohamed Sapian and Mohd Arif, Nasrah and Soh, Tze Vee and Mohd Hashim, Suzana and Abdullah, Norazmi (2020) Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious? American Journal of Infectious Diseases and Microbiology, 8 (3). pp. 113-117. ISSN 2328-4056 E-ISSN 2328-4064 http://pubs.sciepub.com/ajidm/8/3/4/ 10.12691/ajidm-8-3-4
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RC Internal medicine
spellingShingle R Medicine (General)
RC Internal medicine
Wong, Yen Shen
Muhamad, Dzawani
How, Soon Hin
Mohamed, Mohamed Sapian
Mohd Arif, Nasrah
Soh, Tze Vee
Mohd Hashim, Suzana
Abdullah, Norazmi
Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious?
description Coronavirus disease 2019 (COVID-19) is highly contagious in symptomatic patients as it is thought to be transmitted through respiratory droplets. However, it is debatable whether asymptomatic COVID-19 patients are contagious due to lack of data. From 1st March to 15th April 2020, a total of 247 COVID-19 cases were admitted to Tengku Ampuan Afzan Hospital and 1010 close contacts were identified. We studied the epidemiological and clinical outcomes in asymptomatic subjects, as well as estimated the metrics of disease transmission between asymptomatic, symptomatic, and pneumonia subjects. From a total of 125 asymptomatic subjects, majority (n=116,92.8%) remained asymptomatic upon discharge. Only 9 (7.2%) subjects developed mild symptoms after admission. Seven subjects had abnormal chest radiograph suggestive of pneumonia, and 22 subjects (17.6%) were found to have mild liver impairment. None of the asymptomatic subjects required oxygen support, inotropic support or ICU care during admission. Fifteen second generation COVID-19 cases were found transmitted from the asymptomatic group, with an attack rate of 3.9%, which was statistically significantly lower compared to the symptomatic (7.6%) or pneumonia groups (25.7%, p<0.001). In conclusion, asymptomatic COVID-19 patients show excellent clinical outcome. They are infectious but had a lower transmission risk compared with symptomatic or pneumonia patients.
format Article
author Wong, Yen Shen
Muhamad, Dzawani
How, Soon Hin
Mohamed, Mohamed Sapian
Mohd Arif, Nasrah
Soh, Tze Vee
Mohd Hashim, Suzana
Abdullah, Norazmi
author_facet Wong, Yen Shen
Muhamad, Dzawani
How, Soon Hin
Mohamed, Mohamed Sapian
Mohd Arif, Nasrah
Soh, Tze Vee
Mohd Hashim, Suzana
Abdullah, Norazmi
author_sort Wong, Yen Shen
title Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious?
title_short Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious?
title_full Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious?
title_fullStr Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious?
title_full_unstemmed Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious?
title_sort asymptomatic coronavirus disease 2019 (covid-19) carriers: are they infectious?
publisher Science and Education Publishing
publishDate 2020
url http://irep.iium.edu.my/82935/7/82935_Asymptomatic%20coronavirus%20disease%202019%20%28COVID-19%29%20carriers.pdf
http://irep.iium.edu.my/82935/
http://pubs.sciepub.com/ajidm/8/3/4/
_version_ 1681489285558042624
score 13.211869

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