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High prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in Bangladesh

Objectives: Urinary tract infections due to multi drug resistant bacteria have been on the rise globally with serious implications for public health. The objective of this study was to explore the prevalence of multi drug resistant uropathogens and to correlate the urinary tract infections with so...

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Main Authors: Dasgupta, Chandrika, Rafi, Md. Abdur, Salam, Md. Abdus
Format: Article
Language:English
English
Published: Professional Medical Publications 2020
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/82442/1/prof%20salam%20paper1.pdf
http://irep.iium.edu.my/82442/7/82442_High%20prevalence%20of%20multidrug%20resistant%20uropathogens_Scopus.pdf
http://irep.iium.edu.my/82442/
https://www.pjms.org.pk/index.php/pjms/article/view/2943/646
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spelling my.iium.irep.824422021-02-05T08:38:38Z http://irep.iium.edu.my/82442/ High prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in Bangladesh Dasgupta, Chandrika Rafi, Md. Abdur Salam, Md. Abdus R Medicine (General) Objectives: Urinary tract infections due to multi drug resistant bacteria have been on the rise globally with serious implications for public health. The objective of this study was to explore the prevalence of multi drug resistant uropathogens and to correlate the urinary tract infections with some demographic and clinical characteristics of patients admitted in a tertiary care hospital in Bangladesh. Methods: A cross sectional prospective study was conducted at Shaheed Ziaur Rahman Medical College Hospital, Bogura, Bangladesh among clinically suspected urinary tract infection patients from January to December, 2018. Clean-catch midstream or catheter-catch urine samples were subjected to bacteriological culture using chromogenic agar media. Antimicrobial susceptibility testing of the isolates was done by KirbyBauer disk diffusion method following Clinical and Laboratory Standards Institute guidelines. Descriptive statistical methods were used for data analysis. Results: Culture yielded a total of 537 (42.8%) significant bacterial growths including 420 (78.2%) multi drug resistant uropathogens from 1255 urine samples. Escherichia coli was the most common isolate (61.6%) followed by Klebsiella spp. (22.5%), Pseudomonas spp. (7.8%), Staphylococcus aureus (5.4%) and Enterobacter spp. (2.6%) with multi drug resistance frequency of 77.6%, 71.9%, 90.5%, 86.2% and 92.9% respectively. There was female preponderance (M:F; 1:1.97; P=0.007) but insignificant differences between paediatric and adult population (43.65% vs. 42.57%) and also among different age groups. Diabetes, chronic renal failure, fever and supra-pubic pain had significant association as co-morbidities and presentations of urinary tract infections (P<0.05). Multi drug resistance ranged from 3.7 to 88.1% including moderate to high resistance found against commonly used antibiotics like ciprofloxacin, cephalosporin, azithromycin, aztreonam, cotrimoxazole and nalidixic acid (28.6 to 92.9%). Isolates showed 2.4 to 32.2% resistance to nitrofurantoin, amikacin, netilmicin and carbapenems except Pseudomonas spp. (66.7% resistance to nitrofurantoin) and Enterobacter spp. (28.6 to 42.9% resistance to carbapenems). Conclusion: There is very high prevalence of multi drug resistant uropathogens among hospitalized patients and emergence of carbapenem resistance is an alarming situation. Antibiotic stewardship program is highly recommended for hospitals to combat antimicrobial resistance. Professional Medical Publications 2020-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/82442/1/prof%20salam%20paper1.pdf application/pdf en http://irep.iium.edu.my/82442/7/82442_High%20prevalence%20of%20multidrug%20resistant%20uropathogens_Scopus.pdf Dasgupta, Chandrika and Rafi, Md. Abdur and Salam, Md. Abdus (2020) High prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in Bangladesh. Pak J Med Sci, 36 (6). pp. 1297-1302. ISSN 1682-024X https://www.pjms.org.pk/index.php/pjms/article/view/2943/646 : https://doi.org/10.12669/pjms.36.6.2943
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Dasgupta, Chandrika
Rafi, Md. Abdur
Salam, Md. Abdus
High prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in Bangladesh
description Objectives: Urinary tract infections due to multi drug resistant bacteria have been on the rise globally with serious implications for public health. The objective of this study was to explore the prevalence of multi drug resistant uropathogens and to correlate the urinary tract infections with some demographic and clinical characteristics of patients admitted in a tertiary care hospital in Bangladesh. Methods: A cross sectional prospective study was conducted at Shaheed Ziaur Rahman Medical College Hospital, Bogura, Bangladesh among clinically suspected urinary tract infection patients from January to December, 2018. Clean-catch midstream or catheter-catch urine samples were subjected to bacteriological culture using chromogenic agar media. Antimicrobial susceptibility testing of the isolates was done by KirbyBauer disk diffusion method following Clinical and Laboratory Standards Institute guidelines. Descriptive statistical methods were used for data analysis. Results: Culture yielded a total of 537 (42.8%) significant bacterial growths including 420 (78.2%) multi drug resistant uropathogens from 1255 urine samples. Escherichia coli was the most common isolate (61.6%) followed by Klebsiella spp. (22.5%), Pseudomonas spp. (7.8%), Staphylococcus aureus (5.4%) and Enterobacter spp. (2.6%) with multi drug resistance frequency of 77.6%, 71.9%, 90.5%, 86.2% and 92.9% respectively. There was female preponderance (M:F; 1:1.97; P=0.007) but insignificant differences between paediatric and adult population (43.65% vs. 42.57%) and also among different age groups. Diabetes, chronic renal failure, fever and supra-pubic pain had significant association as co-morbidities and presentations of urinary tract infections (P<0.05). Multi drug resistance ranged from 3.7 to 88.1% including moderate to high resistance found against commonly used antibiotics like ciprofloxacin, cephalosporin, azithromycin, aztreonam, cotrimoxazole and nalidixic acid (28.6 to 92.9%). Isolates showed 2.4 to 32.2% resistance to nitrofurantoin, amikacin, netilmicin and carbapenems except Pseudomonas spp. (66.7% resistance to nitrofurantoin) and Enterobacter spp. (28.6 to 42.9% resistance to carbapenems). Conclusion: There is very high prevalence of multi drug resistant uropathogens among hospitalized patients and emergence of carbapenem resistance is an alarming situation. Antibiotic stewardship program is highly recommended for hospitals to combat antimicrobial resistance.
format Article
author Dasgupta, Chandrika
Rafi, Md. Abdur
Salam, Md. Abdus
author_facet Dasgupta, Chandrika
Rafi, Md. Abdur
Salam, Md. Abdus
author_sort Dasgupta, Chandrika
title High prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in Bangladesh
title_short High prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in Bangladesh
title_full High prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in Bangladesh
title_fullStr High prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in Bangladesh
title_full_unstemmed High prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in Bangladesh
title_sort high prevalence of multidrug resistant uropathogens: a recent audit of antimicrobial susceptibility testing from a tertiary care hospital in bangladesh
publisher Professional Medical Publications
publishDate 2020
url http://irep.iium.edu.my/82442/1/prof%20salam%20paper1.pdf
http://irep.iium.edu.my/82442/7/82442_High%20prevalence%20of%20multidrug%20resistant%20uropathogens_Scopus.pdf
http://irep.iium.edu.my/82442/
https://www.pjms.org.pk/index.php/pjms/article/view/2943/646
_version_ 1691732905371369472
score 13.211869

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