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Anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates

Various preparation of skin antisepsis was used to prevent catheter-related blood stream infection (CRBSI) in neonate with central venous catheter (CVC). However, their safety and effectiveness are still uncertain. We assessed the safety and efficacy of different antiseptic solutions in preventing C...

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Main Authors: Muhd Helmi, Muhd Alwi, Mohd Noor, Norhayati
Format: Conference or Workshop Item
Language:English
English
English
Published: 2019
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/82424/1/KL%20International%20Neonatology%20Conference%20%28KLINC%29%20-%20POSTER%20Slot.pdf
http://irep.iium.edu.my/82424/2/Poster%20Presentation-Dr%20Muhd%20Alwi.pdf
http://irep.iium.edu.my/82424/3/Poster%20Cert-Dr%20Muhd%20Alwi.pdf
http://irep.iium.edu.my/82424/
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spelling my.iium.irep.824242020-08-28T01:39:41Z http://irep.iium.edu.my/82424/ Anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates Muhd Helmi, Muhd Alwi Mohd Noor, Norhayati R Medicine (General) Various preparation of skin antisepsis was used to prevent catheter-related blood stream infection (CRBSI) in neonate with central venous catheter (CVC). However, their safety and effectiveness are still uncertain. We assessed the safety and efficacy of different antiseptic solutions in preventing CRBSI and other related outcomes in neonates with CVC including the effects on different subgroups. We searched the Cochrane Central, Epistemonikos, PubMed using keywords and MeSH terms, up to August 2019. We included randomised trials that compared different type of antisepsis. Data were extracted using Cochrane Neonatal Review Group methods. Two authors determined eligibility and risk-of-bias (ROB) of the trials. Results were presented in risk ratio (RR) with 95% confidence intervals (CIs). 2 studies involved 352 neonates were included. Both trials compare 2% chlorhexidine in alcohol (CHD/A) and 10% povidone-iodine (PI). Included studies have mixed ROB. Certainty of evidence was mixed for the major outcomes. There is no significant difference in the risk of CRBSI (RR1.28, 95% CI 0.54 to 3.01), clinical sepsis (RR 0.98, 95% 0.56 to 1.71) and skin irritation (RR 1.04, 95% CI 0.24 to 4.48) between CHD/A and PI. All CHD/A-induced skin irritation occurred on infant less than 28 weeks. There was a significant difference in risk of thyroid disorder (RR 0.05, 95% CI 0.00 to 0.85) favouring CHD/A. There were no clear differences in risk of major outcomes like CRBSI, clinical sepsis and skin irritation between CHD/A and PI. However, the use of PI significantly increases the risk of thyroid dysfunction and should be avoided. 2019-11-21 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/82424/1/KL%20International%20Neonatology%20Conference%20%28KLINC%29%20-%20POSTER%20Slot.pdf application/pdf en http://irep.iium.edu.my/82424/2/Poster%20Presentation-Dr%20Muhd%20Alwi.pdf application/pdf en http://irep.iium.edu.my/82424/3/Poster%20Cert-Dr%20Muhd%20Alwi.pdf Muhd Helmi, Muhd Alwi and Mohd Noor, Norhayati (2019) Anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates. In: 3rd KL International Neonatology Conference (KLINC) in Conjunction with World Prematurity Day 2019, 20-23 November 2019, Sunway Medical Centre, Selangor, Malaysia. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Muhd Helmi, Muhd Alwi
Mohd Noor, Norhayati
Anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates
description Various preparation of skin antisepsis was used to prevent catheter-related blood stream infection (CRBSI) in neonate with central venous catheter (CVC). However, their safety and effectiveness are still uncertain. We assessed the safety and efficacy of different antiseptic solutions in preventing CRBSI and other related outcomes in neonates with CVC including the effects on different subgroups. We searched the Cochrane Central, Epistemonikos, PubMed using keywords and MeSH terms, up to August 2019. We included randomised trials that compared different type of antisepsis. Data were extracted using Cochrane Neonatal Review Group methods. Two authors determined eligibility and risk-of-bias (ROB) of the trials. Results were presented in risk ratio (RR) with 95% confidence intervals (CIs). 2 studies involved 352 neonates were included. Both trials compare 2% chlorhexidine in alcohol (CHD/A) and 10% povidone-iodine (PI). Included studies have mixed ROB. Certainty of evidence was mixed for the major outcomes. There is no significant difference in the risk of CRBSI (RR1.28, 95% CI 0.54 to 3.01), clinical sepsis (RR 0.98, 95% 0.56 to 1.71) and skin irritation (RR 1.04, 95% CI 0.24 to 4.48) between CHD/A and PI. All CHD/A-induced skin irritation occurred on infant less than 28 weeks. There was a significant difference in risk of thyroid disorder (RR 0.05, 95% CI 0.00 to 0.85) favouring CHD/A. There were no clear differences in risk of major outcomes like CRBSI, clinical sepsis and skin irritation between CHD/A and PI. However, the use of PI significantly increases the risk of thyroid dysfunction and should be avoided.
format Conference or Workshop Item
author Muhd Helmi, Muhd Alwi
Mohd Noor, Norhayati
author_facet Muhd Helmi, Muhd Alwi
Mohd Noor, Norhayati
author_sort Muhd Helmi, Muhd Alwi
title Anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates
title_short Anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates
title_full Anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates
title_fullStr Anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates
title_full_unstemmed Anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates
title_sort anti-septic solutions for skin preparation in the care of central-catheter insertion in neonates
publishDate 2019
url http://irep.iium.edu.my/82424/1/KL%20International%20Neonatology%20Conference%20%28KLINC%29%20-%20POSTER%20Slot.pdf
http://irep.iium.edu.my/82424/2/Poster%20Presentation-Dr%20Muhd%20Alwi.pdf
http://irep.iium.edu.my/82424/3/Poster%20Cert-Dr%20Muhd%20Alwi.pdf
http://irep.iium.edu.my/82424/
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score 13.211869

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