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Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin

The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium al...

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Main Authors:	Hassani, Abdelkader, Mahmood, Syed, Enezei, Hamid Hammad, Hussain, Siti Aslina, Hamad, Hamad Ali, Aldoghachi, Ahmed Faris, Hagar, Abdullah, Doolaanea, Abd Almonem, Ibrahim, Wisam Nabeel
Format:	Article
Language:	English English
Published:	MDPI AG 2020
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/80929/1/molecules-25-02244.pdf http://irep.iium.edu.my/80929/7/Scopus%20-formulation%20characterization.pdf http://irep.iium.edu.my/80929/ https://www.mdpi.com/1420-3049/25/9/2244
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spelling	my.iium.irep.809292020-11-18T07:45:15Z http://irep.iium.edu.my/80929/ Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin Hassani, Abdelkader Mahmood, Syed Enezei, Hamid Hammad Hussain, Siti Aslina Hamad, Hamad Ali Aldoghachi, Ahmed Faris Hagar, Abdullah Doolaanea, Abd Almonem Ibrahim, Wisam Nabeel RS Pharmacy and materia medica The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance–Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was –15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy MDPI AG 2020-05-01 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/80929/1/molecules-25-02244.pdf application/pdf en http://irep.iium.edu.my/80929/7/Scopus%20-formulation%20characterization.pdf Hassani, Abdelkader and Mahmood, Syed and Enezei, Hamid Hammad and Hussain, Siti Aslina and Hamad, Hamad Ali and Aldoghachi, Ahmed Faris and Hagar, Abdullah and Doolaanea, Abd Almonem and Ibrahim, Wisam Nabeel (2020) Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin. Molecules, 25 (9). pp. 1-21. ISSN 1420-3049 https://www.mdpi.com/1420-3049/25/9/2244 doi:10.3390/molecules25092244
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Hassani, Abdelkader Mahmood, Syed Enezei, Hamid Hammad Hussain, Siti Aslina Hamad, Hamad Ali Aldoghachi, Ahmed Faris Hagar, Abdullah Doolaanea, Abd Almonem Ibrahim, Wisam Nabeel Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin
description	The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance–Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was –15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy
format	Article
author	Hassani, Abdelkader Mahmood, Syed Enezei, Hamid Hammad Hussain, Siti Aslina Hamad, Hamad Ali Aldoghachi, Ahmed Faris Hagar, Abdullah Doolaanea, Abd Almonem Ibrahim, Wisam Nabeel
author_facet	Hassani, Abdelkader Mahmood, Syed Enezei, Hamid Hammad Hussain, Siti Aslina Hamad, Hamad Ali Aldoghachi, Ahmed Faris Hagar, Abdullah Doolaanea, Abd Almonem Ibrahim, Wisam Nabeel
author_sort	Hassani, Abdelkader
title	Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin
title_short	Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin
title_full	Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin
title_fullStr	Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin
title_full_unstemmed	Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin
title_sort	formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin
publisher	MDPI AG
publishDate	2020
url	http://irep.iium.edu.my/80929/1/molecules-25-02244.pdf http://irep.iium.edu.my/80929/7/Scopus%20-formulation%20characterization.pdf http://irep.iium.edu.my/80929/ https://www.mdpi.com/1420-3049/25/9/2244
_version_	1684653059638034432
score	13.211869

Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin

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