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The effect of probiotics on the development of oral cancer: A systematic review and meta-analysis

Introduction: The prevalence of oral cancer has been reported annually along with high mortality rate. Probiotics have been suggested to possess anti-cancer properties, however the role of these microorganisms on oral cancer is remain unclear. The objective of the present study is to identify the me...

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Main Authors: Wan Mohd Kamaluddin, Wan Nur Fatihah, Ismail, Ahmad Faisal, Mohammad Aidid, Edre, Othman, Noratikah, Arzmi, Mohd Hafiz
Format: Article
Language:English
Published: IIUM Press 2019
Subjects:
QR Microbiology
RK Dentistry
Online Access:http://irep.iium.edu.my/80874/1/637-Manuscript-1800-1-10-20200116.pdf
http://irep.iium.edu.my/80874/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/637/396
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spelling my.iium.irep.808742020-07-01T04:36:16Z http://irep.iium.edu.my/80874/ The effect of probiotics on the development of oral cancer: A systematic review and meta-analysis Wan Mohd Kamaluddin, Wan Nur Fatihah Ismail, Ahmad Faisal Mohammad Aidid, Edre Othman, Noratikah Arzmi, Mohd Hafiz QR Microbiology RK Dentistry Introduction: The prevalence of oral cancer has been reported annually along with high mortality rate. Probiotics have been suggested to possess anti-cancer properties, however the role of these microorganisms on oral cancer is remain unclear. The objective of the present study is to identify the mechanisms exerted by probiotics on oral carcinogenesis by using systematic review and meta analysis with the hypothesis that probiotics inhibit oral carcinogenesis. Materials and method: Comprehensive literature search was conducted on PubMed, Scopus and Web of Science electronic database from January 2019 until April 2019. Main keywords that were used are “probiotic” AND “oral cancer”. Articles that were published in English language were included in this review. Articles were selected independently by three authors and inspected independently by another researcher. The titles and abstracts of the studies were screened to identify studies that meet the inclusion criteria. Full text articles of the remaining studies were assessed to determine the availability to be included in the review. Meta-analysis was conducted by using RevMan 5 software, and the result was graphically plotted on the forest plot. This review was done according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA-P) 2015 guidelines. Results: After thorough screening of the full text articles, seven papers were eligible to be included in the systematic review. The included articles were mainly discussed on the association of probiotics and oral cancer. Two from the seven papers were selected to be analyse for quantitative synthesis (meta-analysis). The present study also showed that, Lactobacillus salivarius REN produces protective effect from developing neoplastic tongue lesions with odd ratio < 1. Conclusion: Probiotics were found to confer positive effect as an inhibitory agent against the oral carcinogenesis thus supported the hypothesis of the present study that probiotics can inhibit oral carcinogenesis. IIUM Press 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/80874/1/637-Manuscript-1800-1-10-20200116.pdf Wan Mohd Kamaluddin, Wan Nur Fatihah and Ismail, Ahmad Faisal and Mohammad Aidid, Edre and Othman, Noratikah and Arzmi, Mohd Hafiz (2019) The effect of probiotics on the development of oral cancer: A systematic review and meta-analysis. International Medical Journal Malaysia, 18 (Supplementary Issue No 2). p. 58. E-ISSN 1823-4631 https://journals.iium.edu.my/kom/index.php/imjm/article/view/637/396
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QR Microbiology
RK Dentistry
spellingShingle QR Microbiology
RK Dentistry
Wan Mohd Kamaluddin, Wan Nur Fatihah
Ismail, Ahmad Faisal
Mohammad Aidid, Edre
Othman, Noratikah
Arzmi, Mohd Hafiz
The effect of probiotics on the development of oral cancer: A systematic review and meta-analysis
description Introduction: The prevalence of oral cancer has been reported annually along with high mortality rate. Probiotics have been suggested to possess anti-cancer properties, however the role of these microorganisms on oral cancer is remain unclear. The objective of the present study is to identify the mechanisms exerted by probiotics on oral carcinogenesis by using systematic review and meta analysis with the hypothesis that probiotics inhibit oral carcinogenesis. Materials and method: Comprehensive literature search was conducted on PubMed, Scopus and Web of Science electronic database from January 2019 until April 2019. Main keywords that were used are “probiotic” AND “oral cancer”. Articles that were published in English language were included in this review. Articles were selected independently by three authors and inspected independently by another researcher. The titles and abstracts of the studies were screened to identify studies that meet the inclusion criteria. Full text articles of the remaining studies were assessed to determine the availability to be included in the review. Meta-analysis was conducted by using RevMan 5 software, and the result was graphically plotted on the forest plot. This review was done according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA-P) 2015 guidelines. Results: After thorough screening of the full text articles, seven papers were eligible to be included in the systematic review. The included articles were mainly discussed on the association of probiotics and oral cancer. Two from the seven papers were selected to be analyse for quantitative synthesis (meta-analysis). The present study also showed that, Lactobacillus salivarius REN produces protective effect from developing neoplastic tongue lesions with odd ratio < 1. Conclusion: Probiotics were found to confer positive effect as an inhibitory agent against the oral carcinogenesis thus supported the hypothesis of the present study that probiotics can inhibit oral carcinogenesis.
format Article
author Wan Mohd Kamaluddin, Wan Nur Fatihah
Ismail, Ahmad Faisal
Mohammad Aidid, Edre
Othman, Noratikah
Arzmi, Mohd Hafiz
author_facet Wan Mohd Kamaluddin, Wan Nur Fatihah
Ismail, Ahmad Faisal
Mohammad Aidid, Edre
Othman, Noratikah
Arzmi, Mohd Hafiz
author_sort Wan Mohd Kamaluddin, Wan Nur Fatihah
title The effect of probiotics on the development of oral cancer: A systematic review and meta-analysis
title_short The effect of probiotics on the development of oral cancer: A systematic review and meta-analysis
title_full The effect of probiotics on the development of oral cancer: A systematic review and meta-analysis
title_fullStr The effect of probiotics on the development of oral cancer: A systematic review and meta-analysis
title_full_unstemmed The effect of probiotics on the development of oral cancer: A systematic review and meta-analysis
title_sort effect of probiotics on the development of oral cancer: a systematic review and meta-analysis
publisher IIUM Press
publishDate 2019
url http://irep.iium.edu.my/80874/1/637-Manuscript-1800-1-10-20200116.pdf
http://irep.iium.edu.my/80874/
https://journals.iium.edu.my/kom/index.php/imjm/article/view/637/396
_version_ 1672610211147284480
score 13.211869

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