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Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray

Background: Electrospray is a method able to produce monodispersed particles using applied electric field to deform the interface of liquid coming out from a capillary. Objectives: The abstract aims to investigate the influence of electrospray critical process parameters (CPPs), including: flow rate...

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Main Authors: Azhar, Muhammad Fitri, Mohd Rus, Shaiqah, Haris @ Harith, Muhammad Salahuddin, Yang, Mingshi, Mu, Huiling
Format: Conference or Workshop Item
Language:English
English
Published: 2020
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/79492/53/combinepdf%20%281%29.pdf
http://irep.iium.edu.my/79492/59/79492_Encapsulation%20of%20fenofibrate_Poster.pdf
http://irep.iium.edu.my/79492/
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spelling my.iium.irep.794922020-12-01T00:52:20Z http://irep.iium.edu.my/79492/ Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray Azhar, Muhammad Fitri Mohd Rus, Shaiqah Haris @ Harith, Muhammad Salahuddin Yang, Mingshi Mu, Huiling RS Pharmacy and materia medica Background: Electrospray is a method able to produce monodispersed particles using applied electric field to deform the interface of liquid coming out from a capillary. Objectives: The abstract aims to investigate the influence of electrospray critical process parameters (CPPs), including: flow rate, solid concentration and tip-to-collector distance on the critical quality attributes (CQAs) of electrosprayed fenofibrate microparticles such as: particle size and yield. Methods: Central composite face-centred (CCF) design was carried out and analysed using partial least square (PLS). Results: The results from the PLS analysis were used to develop models and identify an optimal operating space (OOS). The particle size and the yield models were significant with p-value (<0.05). Flow rate and solid concentration parameters significantly affected the particle size and yield, respectively. A lower flow rate will produce smaller particle size of electrospray particles. Particle size below 2 μm can be obtained when the flow rate is below 13 μL/min for solid concentration between 1-3% (w/w) at 10 cm tip-to-collector distance. In order to increase yield up to 80%, solid concentration should be around 2.8% electrosprayed at distance of 10.25 cm. Discussion and conclusions: Electrospray technique can be used to encapsulate solid lipid fenofibrate microparticles by controlling the parameters including flow rate and solid concentration. The knowledge gained using CCF approach in this study will help in rational experimental design to achieve desired electrospray solid lipid fenofibrate microparticles characteristics. 2020 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/79492/53/combinepdf%20%281%29.pdf application/pdf en http://irep.iium.edu.my/79492/59/79492_Encapsulation%20of%20fenofibrate_Poster.pdf Azhar, Muhammad Fitri and Mohd Rus, Shaiqah and Haris @ Harith, Muhammad Salahuddin and Yang, Mingshi and Mu, Huiling (2020) Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray. In: International Research Conference on Pharmaceutical and Allied Sciences (IRCPAS 2020), 7th-8th March 2020, Kuala Lumpur. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Azhar, Muhammad Fitri
Mohd Rus, Shaiqah
Haris @ Harith, Muhammad Salahuddin
Yang, Mingshi
Mu, Huiling
Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray
description Background: Electrospray is a method able to produce monodispersed particles using applied electric field to deform the interface of liquid coming out from a capillary. Objectives: The abstract aims to investigate the influence of electrospray critical process parameters (CPPs), including: flow rate, solid concentration and tip-to-collector distance on the critical quality attributes (CQAs) of electrosprayed fenofibrate microparticles such as: particle size and yield. Methods: Central composite face-centred (CCF) design was carried out and analysed using partial least square (PLS). Results: The results from the PLS analysis were used to develop models and identify an optimal operating space (OOS). The particle size and the yield models were significant with p-value (<0.05). Flow rate and solid concentration parameters significantly affected the particle size and yield, respectively. A lower flow rate will produce smaller particle size of electrospray particles. Particle size below 2 μm can be obtained when the flow rate is below 13 μL/min for solid concentration between 1-3% (w/w) at 10 cm tip-to-collector distance. In order to increase yield up to 80%, solid concentration should be around 2.8% electrosprayed at distance of 10.25 cm. Discussion and conclusions: Electrospray technique can be used to encapsulate solid lipid fenofibrate microparticles by controlling the parameters including flow rate and solid concentration. The knowledge gained using CCF approach in this study will help in rational experimental design to achieve desired electrospray solid lipid fenofibrate microparticles characteristics.
format Conference or Workshop Item
author Azhar, Muhammad Fitri
Mohd Rus, Shaiqah
Haris @ Harith, Muhammad Salahuddin
Yang, Mingshi
Mu, Huiling
author_facet Azhar, Muhammad Fitri
Mohd Rus, Shaiqah
Haris @ Harith, Muhammad Salahuddin
Yang, Mingshi
Mu, Huiling
author_sort Azhar, Muhammad Fitri
title Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray
title_short Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray
title_full Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray
title_fullStr Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray
title_full_unstemmed Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray
title_sort encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray
publishDate 2020
url http://irep.iium.edu.my/79492/53/combinepdf%20%281%29.pdf
http://irep.iium.edu.my/79492/59/79492_Encapsulation%20of%20fenofibrate_Poster.pdf
http://irep.iium.edu.my/79492/
_version_ 1685578524806610944
score 13.211869

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