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Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach

A selective and sensitive chemosensor for recognizing Co2+ in water sample was optimized from a heterocyclic thiosemicarbazone derivative named 2-acetylpyrazine thiosemicarbazone (AT). The optimization of AT as chemosensor was conducted through RSM experiments using UV- Vis spectroscopy. The interac...

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Main Authors: Ismail, Hakimah, Ahmad, Mohammad Norazmi, Abdullah, Erna Normaya
Format: Conference or Workshop Item
Language:English
English
Published: 2019
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/79369/1/SKAM32%20slide%20print
http://irep.iium.edu.my/79369/2/SKAM32%20PROGRAM%20BOOK.pdf
http://irep.iium.edu.my/79369/
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spelling my.iium.irep.793692020-04-06T13:53:53Z http://irep.iium.edu.my/79369/ Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach Ismail, Hakimah Ahmad, Mohammad Norazmi Abdullah, Erna Normaya QD Chemistry A selective and sensitive chemosensor for recognizing Co2+ in water sample was optimized from a heterocyclic thiosemicarbazone derivative named 2-acetylpyrazine thiosemicarbazone (AT). The optimization of AT as chemosensor was conducted through RSM experiments using UV- Vis spectroscopy. The interaction between AT and Co2+ was found to be optimum in 8:2 v/v DMSO/water at pH 5.3, 100:70 μM AT/Co2+ concentration and 15 minutes reaction time. AT- Co2+ interaction showed colorimetric response from colourless to orange, together with peak- shifting in the absorption spectra from 327 nm to 450 nm. The detection limit of AT towards Co2+ was found to be 3.75 μM while the binding stoichiometry of AT-Co2+ was 2:1. The practicality of AT as chemosensor was tested using three different water samples spiked with Co2+ in the optimized condition. The chemical interaction between AT and Co2+ was further studied through computational studies. DFT calculations for molecular electron potential (MEP), Fukui function and HOMO-LUMO interaction were used to support the experimental results. 2019-08-15 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/79369/1/SKAM32%20slide%20print application/pdf en http://irep.iium.edu.my/79369/2/SKAM32%20PROGRAM%20BOOK.pdf Ismail, Hakimah and Ahmad, Mohammad Norazmi and Abdullah, Erna Normaya (2019) Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach. In: 32nd International Conference of Analytical Sciences (SKAM32), 14-16 August 2019, Port Dickson. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QD Chemistry
spellingShingle QD Chemistry
Ismail, Hakimah
Ahmad, Mohammad Norazmi
Abdullah, Erna Normaya
Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach
description A selective and sensitive chemosensor for recognizing Co2+ in water sample was optimized from a heterocyclic thiosemicarbazone derivative named 2-acetylpyrazine thiosemicarbazone (AT). The optimization of AT as chemosensor was conducted through RSM experiments using UV- Vis spectroscopy. The interaction between AT and Co2+ was found to be optimum in 8:2 v/v DMSO/water at pH 5.3, 100:70 μM AT/Co2+ concentration and 15 minutes reaction time. AT- Co2+ interaction showed colorimetric response from colourless to orange, together with peak- shifting in the absorption spectra from 327 nm to 450 nm. The detection limit of AT towards Co2+ was found to be 3.75 μM while the binding stoichiometry of AT-Co2+ was 2:1. The practicality of AT as chemosensor was tested using three different water samples spiked with Co2+ in the optimized condition. The chemical interaction between AT and Co2+ was further studied through computational studies. DFT calculations for molecular electron potential (MEP), Fukui function and HOMO-LUMO interaction were used to support the experimental results.
format Conference or Workshop Item
author Ismail, Hakimah
Ahmad, Mohammad Norazmi
Abdullah, Erna Normaya
author_facet Ismail, Hakimah
Ahmad, Mohammad Norazmi
Abdullah, Erna Normaya
author_sort Ismail, Hakimah
title Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach
title_short Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach
title_full Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach
title_fullStr Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach
title_full_unstemmed Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach
title_sort chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach
publishDate 2019
url http://irep.iium.edu.my/79369/1/SKAM32%20slide%20print
http://irep.iium.edu.my/79369/2/SKAM32%20PROGRAM%20BOOK.pdf
http://irep.iium.edu.my/79369/
_version_ 1665894798385479680
score 13.211869

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