Cover Image

Plasma concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in short and long term opioid users with non-cancer pain

INTRODUCTION Little is known whether the duration of opioid use influences the concentrations of pro and anti-inflammatory cytokines. OBJECTIVES This study examined the plasma concentration of pro-inflammatory cytokine, IL-6, and anti-inflammatory cytokine, IL-10, in short, and long-term opio...

Full description

Saved in:
Bibliographic Details
Main Authors: Mizher, Hussam A., Zin, Che Suraya, Helal Uddin, A.B.M., Mohamed, Abdul Hadi, Tan, Hung Ling, M. Izat, Munira
Format: Conference or Workshop Item
Language:English
English
English
Published: 2019
Subjects:
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/75871/1/191104_main%20page_program.pdf
http://irep.iium.edu.my/75871/2/191104_hosam_oral_program.pdf
http://irep.iium.edu.my/75871/11/191017_icprp_hosam_17102019_ICPRP%20presentation.pdf
http://irep.iium.edu.my/75871/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.iium.irep.75871
record_format dspace
spelling my.iium.irep.758712022-11-07T03:45:17Z http://irep.iium.edu.my/75871/ Plasma concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in short and long term opioid users with non-cancer pain Mizher, Hussam A. Zin, Che Suraya Helal Uddin, A.B.M. Mohamed, Abdul Hadi Tan, Hung Ling M. Izat, Munira RM Therapeutics. Pharmacology INTRODUCTION Little is known whether the duration of opioid use influences the concentrations of pro and anti-inflammatory cytokines. OBJECTIVES This study examined the plasma concentration of pro-inflammatory cytokine, IL-6, and anti-inflammatory cytokine, IL-10, in short, and long-term opioid users with non-cancer pain. METHOD Adult patients with opioid therapy for noncancer pain were recruited from pain clinics at two tertiary hospital settings in Malaysia between February 2016 and March 2017. They were stratified into short-or long-term users based on opioid prescriptions ≥ 90 days per year. A 10 ml blood sample was taken for the analysis of plasma concentrations of IL-6 and IL-10 and were quantified using a highly sensitive multiplex assay. RESULTS Of 38 patients recruited, 24% (n=9/38) and 76% (n=29/38) were respectively short and long-term opioid users. Short term use of opioid was associated with higher levels of IL-6 (mean ±SD, 173.9 ± 13.7 pg/ml) and IL-10 (50 ± 5.8 pg/ml), while long term use of opioids was associated with lower levels (no significant difference) of both cytokines (IL6 (125 ± 16.1 pg/ml) and IL10 (41.3 ± 6.7 pg/ml). There was strong correlation between IL-6 and IL-10 within the same group (r² = 0.72, p < 0.05) and (r² = 0.76, p<0.05) for short and long-term users, respectively. CONCLUSION The duration of opioid use may modulate the level of pro-inflammatory cytokines in which it was higher in short term use and lower in long term use, but the effect of pain relief was similar as both cytokines were well correlated. 2019-10-19 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/75871/1/191104_main%20page_program.pdf application/pdf en http://irep.iium.edu.my/75871/2/191104_hosam_oral_program.pdf application/pdf en http://irep.iium.edu.my/75871/11/191017_icprp_hosam_17102019_ICPRP%20presentation.pdf Mizher, Hussam A. and Zin, Che Suraya and Helal Uddin, A.B.M. and Mohamed, Abdul Hadi and Tan, Hung Ling and M. Izat, Munira (2019) Plasma concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in short and long term opioid users with non-cancer pain. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19-20th October 2019, Hotel Istana Kuala Lumpur. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic RM Therapeutics. Pharmacology
spellingShingle RM Therapeutics. Pharmacology
Mizher, Hussam A.
Zin, Che Suraya
Helal Uddin, A.B.M.
Mohamed, Abdul Hadi
Tan, Hung Ling
M. Izat, Munira
Plasma concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in short and long term opioid users with non-cancer pain
description INTRODUCTION Little is known whether the duration of opioid use influences the concentrations of pro and anti-inflammatory cytokines. OBJECTIVES This study examined the plasma concentration of pro-inflammatory cytokine, IL-6, and anti-inflammatory cytokine, IL-10, in short, and long-term opioid users with non-cancer pain. METHOD Adult patients with opioid therapy for noncancer pain were recruited from pain clinics at two tertiary hospital settings in Malaysia between February 2016 and March 2017. They were stratified into short-or long-term users based on opioid prescriptions ≥ 90 days per year. A 10 ml blood sample was taken for the analysis of plasma concentrations of IL-6 and IL-10 and were quantified using a highly sensitive multiplex assay. RESULTS Of 38 patients recruited, 24% (n=9/38) and 76% (n=29/38) were respectively short and long-term opioid users. Short term use of opioid was associated with higher levels of IL-6 (mean ±SD, 173.9 ± 13.7 pg/ml) and IL-10 (50 ± 5.8 pg/ml), while long term use of opioids was associated with lower levels (no significant difference) of both cytokines (IL6 (125 ± 16.1 pg/ml) and IL10 (41.3 ± 6.7 pg/ml). There was strong correlation between IL-6 and IL-10 within the same group (r² = 0.72, p < 0.05) and (r² = 0.76, p<0.05) for short and long-term users, respectively. CONCLUSION The duration of opioid use may modulate the level of pro-inflammatory cytokines in which it was higher in short term use and lower in long term use, but the effect of pain relief was similar as both cytokines were well correlated.
format Conference or Workshop Item
author Mizher, Hussam A.
Zin, Che Suraya
Helal Uddin, A.B.M.
Mohamed, Abdul Hadi
Tan, Hung Ling
M. Izat, Munira
author_facet Mizher, Hussam A.
Zin, Che Suraya
Helal Uddin, A.B.M.
Mohamed, Abdul Hadi
Tan, Hung Ling
M. Izat, Munira
author_sort Mizher, Hussam A.
title Plasma concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in short and long term opioid users with non-cancer pain
title_short Plasma concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in short and long term opioid users with non-cancer pain
title_full Plasma concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in short and long term opioid users with non-cancer pain
title_fullStr Plasma concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in short and long term opioid users with non-cancer pain
title_full_unstemmed Plasma concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 in short and long term opioid users with non-cancer pain
title_sort plasma concentrations of pro-inflammatory cytokine il-6 and anti-inflammatory cytokine il-10 in short and long term opioid users with non-cancer pain
publishDate 2019
url http://irep.iium.edu.my/75871/1/191104_main%20page_program.pdf
http://irep.iium.edu.my/75871/2/191104_hosam_oral_program.pdf
http://irep.iium.edu.my/75871/11/191017_icprp_hosam_17102019_ICPRP%20presentation.pdf
http://irep.iium.edu.my/75871/
_version_ 1751535891406389248
score 13.211869

Similar Items