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Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens

Introduction: Eurycoma longifolia jack (E.L) is a herbal medicinal plant of South-East Asian origin, popularly recognized as ‘Tongkat Ali.’ The plant roots have been scientifically proven to have many biological effects including antibacterial activity however, no previous research to date has st...

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Main Authors: Alloha, Irani, Binti Aziz, Nurul ‘Ain Liyana, Faisal, Ghasak Ghazi, Abllah, Zurainie, Arzmi, Mohd Hafiz
Format: Article
Language:English
English
Published: 2019
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/75384/7/75384%20Effects%20of%20Eurycoma%20Longifolia%20Jack.pdf
http://irep.iium.edu.my/75384/8/75384%20Effects%20of%20Eurycoma%20Longifolia%20Jack%20SCOPUS.pdf
http://irep.iium.edu.my/75384/
https://phcogj.com/sites/default/files/PJ-11-6-165.pdf
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spelling my.iium.irep.753842019-11-15T01:47:14Z http://irep.iium.edu.my/75384/ Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens Alloha, Irani Binti Aziz, Nurul ‘Ain Liyana Faisal, Ghasak Ghazi Abllah, Zurainie Arzmi, Mohd Hafiz RB Pathology Introduction: Eurycoma longifolia jack (E.L) is a herbal medicinal plant of South-East Asian origin, popularly recognized as ‘Tongkat Ali.’ The plant roots have been scientifically proven to have many biological effects including antibacterial activity however, no previous research to date has studied the effect on oral pathogens including cariogenic bacteria. This study was done to determine the antibacterial and antifungal activities of E.L. root extract against three common oral pathogens. Material and Methods: The microorganisms used were Candida albicans, Streptococcus mutans and Lactobacillus casei. E.L root was extracted using soxhlet method. Disc diffusion assay was conducted using extract concentration of 200 mg/ml. Nystatin and Ampicillin were used as positive control for fungal and bacterial tests respectively. Minimum Inhibitory Concentration (MIC) was done to determine the lowest inhibitory concentration of the extract on the microorganisms. Results: E.L extract inhibited the growth of Candida albicans and Streptococcus mutans at a concentration of 200 mg/ ml with a zone of inhibition of 16.0 ± 3.0 mm and 7.0 ± 1.0 mm respectively. There was no antimicrobial effect of the extract on Lactobacillus casei. The MIC of E.L extract against both Candida albicans and Streptococcus mutans was 25 mg/ml. Conclusions: The results from this study revealed the potential use of Eurycoma longifolia jack as an antimicrobial agent which can be used to produce new oral care products. 2019-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/75384/7/75384%20Effects%20of%20Eurycoma%20Longifolia%20Jack.pdf application/pdf en http://irep.iium.edu.my/75384/8/75384%20Effects%20of%20Eurycoma%20Longifolia%20Jack%20SCOPUS.pdf Alloha, Irani and Binti Aziz, Nurul ‘Ain Liyana and Faisal, Ghasak Ghazi and Abllah, Zurainie and Arzmi, Mohd Hafiz (2019) Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens. Pharmacognosy Journal, 11 (5). pp. 1299-1302. ISSN 0975-3575 https://phcogj.com/sites/default/files/PJ-11-6-165.pdf 10.5530/pj.2019.11.201
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RB Pathology
spellingShingle RB Pathology
Alloha, Irani
Binti Aziz, Nurul ‘Ain Liyana
Faisal, Ghasak Ghazi
Abllah, Zurainie
Arzmi, Mohd Hafiz
Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens
description Introduction: Eurycoma longifolia jack (E.L) is a herbal medicinal plant of South-East Asian origin, popularly recognized as ‘Tongkat Ali.’ The plant roots have been scientifically proven to have many biological effects including antibacterial activity however, no previous research to date has studied the effect on oral pathogens including cariogenic bacteria. This study was done to determine the antibacterial and antifungal activities of E.L. root extract against three common oral pathogens. Material and Methods: The microorganisms used were Candida albicans, Streptococcus mutans and Lactobacillus casei. E.L root was extracted using soxhlet method. Disc diffusion assay was conducted using extract concentration of 200 mg/ml. Nystatin and Ampicillin were used as positive control for fungal and bacterial tests respectively. Minimum Inhibitory Concentration (MIC) was done to determine the lowest inhibitory concentration of the extract on the microorganisms. Results: E.L extract inhibited the growth of Candida albicans and Streptococcus mutans at a concentration of 200 mg/ ml with a zone of inhibition of 16.0 ± 3.0 mm and 7.0 ± 1.0 mm respectively. There was no antimicrobial effect of the extract on Lactobacillus casei. The MIC of E.L extract against both Candida albicans and Streptococcus mutans was 25 mg/ml. Conclusions: The results from this study revealed the potential use of Eurycoma longifolia jack as an antimicrobial agent which can be used to produce new oral care products.
format Article
author Alloha, Irani
Binti Aziz, Nurul ‘Ain Liyana
Faisal, Ghasak Ghazi
Abllah, Zurainie
Arzmi, Mohd Hafiz
author_facet Alloha, Irani
Binti Aziz, Nurul ‘Ain Liyana
Faisal, Ghasak Ghazi
Abllah, Zurainie
Arzmi, Mohd Hafiz
author_sort Alloha, Irani
title Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens
title_short Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens
title_full Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens
title_fullStr Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens
title_full_unstemmed Effects of Eurycoma longifolia jack (Tongkat Ali) alcoholic root extract against oral pathogens
title_sort effects of eurycoma longifolia jack (tongkat ali) alcoholic root extract against oral pathogens
publishDate 2019
url http://irep.iium.edu.my/75384/7/75384%20Effects%20of%20Eurycoma%20Longifolia%20Jack.pdf
http://irep.iium.edu.my/75384/8/75384%20Effects%20of%20Eurycoma%20Longifolia%20Jack%20SCOPUS.pdf
http://irep.iium.edu.my/75384/
https://phcogj.com/sites/default/files/PJ-11-6-165.pdf
_version_ 1651865982954635264
score 13.211869

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