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Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach

In this study, response surface methodology (RSM) in combination with central composite rotatable design (CCRD) were performed to optimize the extraction parameters for total phenolic content (TPC) on Syzygium aqueum (S. aqueum) leaves. The effect of operational conditions on the extraction of S. aq...

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Main Authors: Zarudin, Nurul Husna, Abdullah, Erna Normaya, Yunus, Kamaruzzaman, Ku Bulat, Ku Halim, Ahmad, Mohammad Norazmi
Format: Conference or Workshop Item
Language:English
English
English
Published: 2019
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/75325/1/FINAL-ABSTRACT-BOOK-2019.pdf
http://irep.iium.edu.my/75325/7/75325%20%20%20%20%20%20PRELIMINARY%20STUDY%20IN%20DISCOVERING.pdf
http://irep.iium.edu.my/75325/13/IWANCOS%20Presentation%20Ahmad%20et%20al.%202019c.pdf
http://irep.iium.edu.my/75325/
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spelling my.iium.irep.753252019-11-15T05:36:19Z http://irep.iium.edu.my/75325/ Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach Zarudin, Nurul Husna Abdullah, Erna Normaya Yunus, Kamaruzzaman Ku Bulat, Ku Halim Ahmad, Mohammad Norazmi QD Chemistry In this study, response surface methodology (RSM) in combination with central composite rotatable design (CCRD) were performed to optimize the extraction parameters for total phenolic content (TPC) on Syzygium aqueum (S. aqueum) leaves. The effect of operational conditions on the extraction of S. aqueum leaves using carbon dioxide (CO2) on TPC was investigated. The conditions used in the supercritical extraction with CO2 included temperatures of (40-70 °C), pressures (2200-4500 psi) and extraction time (40-100 min). The highest TPC (3.5893 mg GAE/mg) was obtained at optimum conditions of 55 °C, 3350 psi and 70 min. The major compound in the optimized crude extract was2-propen-1-one,1-(2,4Dihydroxyphenyl)-3-(4-methoxyphenyl)- (82.65 %) which was identified by GC-MS. COSMO-RS was introduced to study the σ-profile between CO2 and 2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4methoxyphenyl)-. Principal component analysis (PCA) was performed to classify major compound which exhibit similar chemical properties with selected control. 2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4methoxyphenyl)- has similar chemical properties with kaempferol as tyrosinase inhibitor. Molecular electrostatic potential (MEP) and molecular docking were plotted to investigate a recognition manner of 2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4-methoxyphenyl)-upon tyrosinase receptor. 2019 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/75325/1/FINAL-ABSTRACT-BOOK-2019.pdf application/pdf en http://irep.iium.edu.my/75325/7/75325%20%20%20%20%20%20PRELIMINARY%20STUDY%20IN%20DISCOVERING.pdf application/pdf en http://irep.iium.edu.my/75325/13/IWANCOS%20Presentation%20Ahmad%20et%20al.%202019c.pdf Zarudin, Nurul Husna and Abdullah, Erna Normaya and Yunus, Kamaruzzaman and Ku Bulat, Ku Halim and Ahmad, Mohammad Norazmi (2019) Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach. In: International Conference on Clean Water, Air and Soil (CLEANWAS 2019), 26th-28th July 2019, Hanoi, Vietnam. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic QD Chemistry
spellingShingle QD Chemistry
Zarudin, Nurul Husna
Abdullah, Erna Normaya
Yunus, Kamaruzzaman
Ku Bulat, Ku Halim
Ahmad, Mohammad Norazmi
Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach
description In this study, response surface methodology (RSM) in combination with central composite rotatable design (CCRD) were performed to optimize the extraction parameters for total phenolic content (TPC) on Syzygium aqueum (S. aqueum) leaves. The effect of operational conditions on the extraction of S. aqueum leaves using carbon dioxide (CO2) on TPC was investigated. The conditions used in the supercritical extraction with CO2 included temperatures of (40-70 °C), pressures (2200-4500 psi) and extraction time (40-100 min). The highest TPC (3.5893 mg GAE/mg) was obtained at optimum conditions of 55 °C, 3350 psi and 70 min. The major compound in the optimized crude extract was2-propen-1-one,1-(2,4Dihydroxyphenyl)-3-(4-methoxyphenyl)- (82.65 %) which was identified by GC-MS. COSMO-RS was introduced to study the σ-profile between CO2 and 2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4methoxyphenyl)-. Principal component analysis (PCA) was performed to classify major compound which exhibit similar chemical properties with selected control. 2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4methoxyphenyl)- has similar chemical properties with kaempferol as tyrosinase inhibitor. Molecular electrostatic potential (MEP) and molecular docking were plotted to investigate a recognition manner of 2-propen-1-one,1-(2,4-Dihydroxyphenyl)-3-(4-methoxyphenyl)-upon tyrosinase receptor.
format Conference or Workshop Item
author Zarudin, Nurul Husna
Abdullah, Erna Normaya
Yunus, Kamaruzzaman
Ku Bulat, Ku Halim
Ahmad, Mohammad Norazmi
author_facet Zarudin, Nurul Husna
Abdullah, Erna Normaya
Yunus, Kamaruzzaman
Ku Bulat, Ku Halim
Ahmad, Mohammad Norazmi
author_sort Zarudin, Nurul Husna
title Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach
title_short Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach
title_full Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach
title_fullStr Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach
title_full_unstemmed Preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach
title_sort preliminary study in discovering 2-propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)- from syzygium aqueum leaves as a tyrosinase inhibitor in food product: experimental and theoretical approach
publishDate 2019
url http://irep.iium.edu.my/75325/1/FINAL-ABSTRACT-BOOK-2019.pdf
http://irep.iium.edu.my/75325/7/75325%20%20%20%20%20%20PRELIMINARY%20STUDY%20IN%20DISCOVERING.pdf
http://irep.iium.edu.my/75325/13/IWANCOS%20Presentation%20Ahmad%20et%20al.%202019c.pdf
http://irep.iium.edu.my/75325/
_version_ 1651865981180444672
score 13.211869

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