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Biodegradable microparticles and nanoparticles by electrospraying techniques

Purpose: Biodegradable microparticles and nanoparticles are receiving increased attention for their ability to serve as a vi- able carrier for site-specific delivery of genes, drugs and other biomolecules. Electrospraying represents a challenging tech- nology which allows for the preparation of biod...

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Main Authors: Guarino, Vincenzo, Wan Abdul Khodir, Wan Khartini, Ambrosio, Luigi
Format: Article
Language:English
Published: SAGE Publishing 2012
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/75244/1/guarino2012_JABFM.pdf
http://irep.iium.edu.my/75244/
https://journals.sagepub.com/doi/pdf/10.5301/JABFM.2012.10369
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spelling my.iium.irep.752442021-05-24T06:53:05Z http://irep.iium.edu.my/75244/ Biodegradable microparticles and nanoparticles by electrospraying techniques Guarino, Vincenzo Wan Abdul Khodir, Wan Khartini Ambrosio, Luigi QD Chemistry Purpose: Biodegradable microparticles and nanoparticles are receiving increased attention for their ability to serve as a vi- able carrier for site-specific delivery of genes, drugs and other biomolecules. Electrospraying represents a challenging tech- nology which allows for the preparation of biodegradable particles with high bioavailability, good encapsulation, controlled release and fewer toxic properties. Methods: chitosan and polycaprolactone (PcL) particles were processed via electrospraying with control of basic process parameters: voltage and flow rate. Results: PcL microparticles with spherical shape or flattened particles were obtained as a function of the concentration of the processed solutions, which affects evaporation and chain entanglement formation. chitosan nanoparticles with submi- crometric sizes were obtained by carefully adjusting voltage and flow rate, which enables the control of particle size and distribution. Conclusion: We evaluated the benefits of the electrospraying technique to control the morphology of biodegradable mic- roparticles and nanoparticles for drug-delivery applications. the implementation of simple technological solutions which combine the use of standard electrospraying and electrospinning by simultaneous or sequential steps, opens the way toward the development of new, interesting devices for drug-delivery applications such as tumor targeting and oral delivery. SAGE Publishing 2012-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/75244/1/guarino2012_JABFM.pdf Guarino, Vincenzo and Wan Abdul Khodir, Wan Khartini and Ambrosio, Luigi (2012) Biodegradable microparticles and nanoparticles by electrospraying techniques. Journal of Applied Biomaterials & Functional Materials, 10 (3 (September-December)). pp. 191-196. ISSN 2280-8000 E-ISSN 2280-8000 https://journals.sagepub.com/doi/pdf/10.5301/JABFM.2012.10369 10.5301/JABFM.2012.10369
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Guarino, Vincenzo
Wan Abdul Khodir, Wan Khartini
Ambrosio, Luigi
Biodegradable microparticles and nanoparticles by electrospraying techniques
description Purpose: Biodegradable microparticles and nanoparticles are receiving increased attention for their ability to serve as a vi- able carrier for site-specific delivery of genes, drugs and other biomolecules. Electrospraying represents a challenging tech- nology which allows for the preparation of biodegradable particles with high bioavailability, good encapsulation, controlled release and fewer toxic properties. Methods: chitosan and polycaprolactone (PcL) particles were processed via electrospraying with control of basic process parameters: voltage and flow rate. Results: PcL microparticles with spherical shape or flattened particles were obtained as a function of the concentration of the processed solutions, which affects evaporation and chain entanglement formation. chitosan nanoparticles with submi- crometric sizes were obtained by carefully adjusting voltage and flow rate, which enables the control of particle size and distribution. Conclusion: We evaluated the benefits of the electrospraying technique to control the morphology of biodegradable mic- roparticles and nanoparticles for drug-delivery applications. the implementation of simple technological solutions which combine the use of standard electrospraying and electrospinning by simultaneous or sequential steps, opens the way toward the development of new, interesting devices for drug-delivery applications such as tumor targeting and oral delivery.
format Article
author Guarino, Vincenzo
Wan Abdul Khodir, Wan Khartini
Ambrosio, Luigi
author_facet Guarino, Vincenzo
Wan Abdul Khodir, Wan Khartini
Ambrosio, Luigi
author_sort Guarino, Vincenzo
title Biodegradable microparticles and nanoparticles by electrospraying techniques
title_short Biodegradable microparticles and nanoparticles by electrospraying techniques
title_full Biodegradable microparticles and nanoparticles by electrospraying techniques
title_fullStr Biodegradable microparticles and nanoparticles by electrospraying techniques
title_full_unstemmed Biodegradable microparticles and nanoparticles by electrospraying techniques
title_sort biodegradable microparticles and nanoparticles by electrospraying techniques
publisher SAGE Publishing
publishDate 2012
url http://irep.iium.edu.my/75244/1/guarino2012_JABFM.pdf
http://irep.iium.edu.my/75244/
https://journals.sagepub.com/doi/pdf/10.5301/JABFM.2012.10369
_version_ 1701162758453592064
score 13.211869

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