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Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods...

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Main Authors: Rullah, Malaysia, Mohd Aluwi, Mohd Fadhlizil Fasihi, Khor, Poh Yen, Kok Wai, Lam
Format: Article
Language:English
English
Published: Elsevier 2019
Subjects:
RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:http://irep.iium.edu.my/75023/1/1-s2.0-S0223523419308566-main.pdf
http://irep.iium.edu.my/75023/7/75023_Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin_scopus.pdf
http://irep.iium.edu.my/75023/
https://www.sciencedirect.com/science/article/pii/S0223523419308566
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spelling my.iium.irep.750232019-10-26T17:24:45Z http://irep.iium.edu.my/75023/ Insights on the synthesis of asymmetric curcumin derivatives and their biological activities Rullah, Malaysia Mohd Aluwi, Mohd Fadhlizil Fasihi Khor, Poh Yen Kok Wai, Lam RS403 Materia Medica-Pharmaceutical Chemistry Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine. Elsevier 2019-12-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/75023/1/1-s2.0-S0223523419308566-main.pdf application/pdf en http://irep.iium.edu.my/75023/7/75023_Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin_scopus.pdf Rullah, Malaysia and Mohd Aluwi, Mohd Fadhlizil Fasihi and Khor, Poh Yen and Kok Wai, Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234 https://www.sciencedirect.com/science/article/pii/S0223523419308566 10.1016/j.ejmech.2019.111704
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle RS403 Materia Medica-Pharmaceutical Chemistry
Rullah, Malaysia
Mohd Aluwi, Mohd Fadhlizil Fasihi
Khor, Poh Yen
Kok Wai, Lam
Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
description Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine.
format Article
author Rullah, Malaysia
Mohd Aluwi, Mohd Fadhlizil Fasihi
Khor, Poh Yen
Kok Wai, Lam
author_facet Rullah, Malaysia
Mohd Aluwi, Mohd Fadhlizil Fasihi
Khor, Poh Yen
Kok Wai, Lam
author_sort Rullah, Malaysia
title Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_short Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_full Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_fullStr Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_full_unstemmed Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_sort insights on the synthesis of asymmetric curcumin derivatives and their biological activities
publisher Elsevier
publishDate 2019
url http://irep.iium.edu.my/75023/1/1-s2.0-S0223523419308566-main.pdf
http://irep.iium.edu.my/75023/7/75023_Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin_scopus.pdf
http://irep.iium.edu.my/75023/
https://www.sciencedirect.com/science/article/pii/S0223523419308566
_version_ 1648739832199905280
score 13.211869

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