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Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2)

Recently, the leaves of tomato plant that contained several active compound including alkaloid, steroid and flavanoid has been used for treatment of variety of diseases included anticancer, anti-oxidant and anti-gout. Although a number of pharmacological properties have already been demonstrat...

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Main Authors: Semail, Sulawati, Amid, Azura, Jamal, Parveen
Format: Conference or Workshop Item
Language:English
Published: 2011
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/7469/1/irep.iium.edu.my_7469.pdf
http://irep.iium.edu.my/7469/
http://www.iium.edu.my/icbioe/2011/
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spelling my.iium.irep.74692011-11-29T15:13:55Z http://irep.iium.edu.my/7469/ Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2) Semail, Sulawati Amid, Azura Jamal, Parveen R Medicine (General) Recently, the leaves of tomato plant that contained several active compound including alkaloid, steroid and flavanoid has been used for treatment of variety of diseases included anticancer, anti-oxidant and anti-gout. Although a number of pharmacological properties have already been demonstrated, the anti-inflammatory effect of tomato leaves action and its associated molecular mechanisms have not yet been fully investigated. In this study, in order to observe the antiinflammatory action of Solanum lycopersicum extract on lipopolysaccharide (LPS)-stimulated macrophages, its inhibitory of inflammation activity was investigated by observing the Prostaglandin E2 (PGE2 ) production using PGE2 enzyme immunometric assay kit (Cayman CO., Ann Arbor, MI, USA). Results showed that the tomato leaves extract inhibited the productions of inflammatory mediators (PGE2 ) which plays a central role in the anti-inflammatory activity. At the highest concentration (100µg/ml) of tomato leaves extract tested, the PGE2 production was reduced 37.41% compared to the untreated. The COX-2 gene expression also reduced following increment in the extract concentration. Hence, these present study may support that the leaves of Solanum lycopersicum extract potentially use in treatment of inflammatory related disease through the inhibition of PGE2 releases. 2011-05-17 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/7469/1/irep.iium.edu.my_7469.pdf Semail, Sulawati and Amid, Azura and Jamal, Parveen (2011) Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2). In: International Conference on Biotechnology Engineering (ICBioE 2011), 17-19 May, 2011 , Kuala Lumpur. http://www.iium.edu.my/icbioe/2011/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Semail, Sulawati
Amid, Azura
Jamal, Parveen
Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2)
description Recently, the leaves of tomato plant that contained several active compound including alkaloid, steroid and flavanoid has been used for treatment of variety of diseases included anticancer, anti-oxidant and anti-gout. Although a number of pharmacological properties have already been demonstrated, the anti-inflammatory effect of tomato leaves action and its associated molecular mechanisms have not yet been fully investigated. In this study, in order to observe the antiinflammatory action of Solanum lycopersicum extract on lipopolysaccharide (LPS)-stimulated macrophages, its inhibitory of inflammation activity was investigated by observing the Prostaglandin E2 (PGE2 ) production using PGE2 enzyme immunometric assay kit (Cayman CO., Ann Arbor, MI, USA). Results showed that the tomato leaves extract inhibited the productions of inflammatory mediators (PGE2 ) which plays a central role in the anti-inflammatory activity. At the highest concentration (100µg/ml) of tomato leaves extract tested, the PGE2 production was reduced 37.41% compared to the untreated. The COX-2 gene expression also reduced following increment in the extract concentration. Hence, these present study may support that the leaves of Solanum lycopersicum extract potentially use in treatment of inflammatory related disease through the inhibition of PGE2 releases.
format Conference or Workshop Item
author Semail, Sulawati
Amid, Azura
Jamal, Parveen
author_facet Semail, Sulawati
Amid, Azura
Jamal, Parveen
author_sort Semail, Sulawati
title Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2)
title_short Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2)
title_full Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2)
title_fullStr Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2)
title_full_unstemmed Tomato leaves methanol extract posses anti-inflammatory activity via inhibition of Lipopolysacharide (LPS)-induced Prostaglandin (PGE2)
title_sort tomato leaves methanol extract posses anti-inflammatory activity via inhibition of lipopolysacharide (lps)-induced prostaglandin (pge2)
publishDate 2011
url http://irep.iium.edu.my/7469/1/irep.iium.edu.my_7469.pdf
http://irep.iium.edu.my/7469/
http://www.iium.edu.my/icbioe/2011/
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score 13.211869

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