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Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats

Introduction: Hypertension is having an increasing impact on the world population’s morbidity and mortality. The pathogenesis of hypertension is multifactorial but the ‘adrenaline hypothesis’ is being increasingly identified as a cause for hypertension in the young. Objective: The aim of this stud...

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Main Authors: Abdullah, Aszrin, Mohd Noor, Noriah, Abdul Razak, Tariq
Format: Article
Language:English
Published: Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2015
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/73868/1/IMJM-Vol-14-Supp-p09-10-Aszrin-Abdullah.pdf
http://irep.iium.edu.my/73868/
http://iiumedic.net/imjm/v1/download/volume_14_supplement/IMJM-Vol-14-Supp-p09-Aszrin-Abdullah.pdf
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spelling my.iium.irep.738682021-01-28T02:56:12Z http://irep.iium.edu.my/73868/ Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats Abdullah, Aszrin Mohd Noor, Noriah Abdul Razak, Tariq R Medicine (General) Introduction: Hypertension is having an increasing impact on the world population’s morbidity and mortality. The pathogenesis of hypertension is multifactorial but the ‘adrenaline hypothesis’ is being increasingly identified as a cause for hypertension in the young. Objective: The aim of this study is to assess the extent and sustainability of blood pressure fall following peripheral blockade of adrenaline synthesis and to assess the use of THIQ and its ability to block peripheral adrenaline synthesis. ive rats (SHRs) of Wistar-Kyoto Japanese strain rats were obtained and randomised into treated and control groups. Indirect systolic blood pressure (SBP) was measured under ether anaesthesia. 1,2,3,4-Tetrahydroisoquinoline administered chronically. Blood collected for plasma catecholamine measurement and BP/HR measured at regular intervals. Results: Baseline SBP, HR and body weight comparable between treated and control groups (p=1.00, p=0.20 and p=0.22, respectively). Significant SBP drop seen post PNMTI administration (p=0.02). SBP also showed significant drop in week 1 (p=0.03) and week 2 post treatment (p=0.04). Treated SHR plasma catecholamine and dopamine levels also dropped 2-weeks following the PNMTI administration (p= 0.04). Conclusion: This study is consistent with adrenaline hypothesis in the pathogenesis of essential hypertension in young spontaneously hypertensive rats. Consequently, we have also shown that chronic adrenal medullary inhibition with 1,2,3,4-Tetrahydroisoquinoline will result in sustained BP reduction. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2015-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/73868/1/IMJM-Vol-14-Supp-p09-10-Aszrin-Abdullah.pdf Abdullah, Aszrin and Mohd Noor, Noriah and Abdul Razak, Tariq (2015) Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats. International Medical Journal Malaysia, 14 (Supplement). pp. 9-10. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_14_supplement/IMJM-Vol-14-Supp-p09-Aszrin-Abdullah.pdf
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Abdullah, Aszrin
Mohd Noor, Noriah
Abdul Razak, Tariq
Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats
description Introduction: Hypertension is having an increasing impact on the world population’s morbidity and mortality. The pathogenesis of hypertension is multifactorial but the ‘adrenaline hypothesis’ is being increasingly identified as a cause for hypertension in the young. Objective: The aim of this study is to assess the extent and sustainability of blood pressure fall following peripheral blockade of adrenaline synthesis and to assess the use of THIQ and its ability to block peripheral adrenaline synthesis. ive rats (SHRs) of Wistar-Kyoto Japanese strain rats were obtained and randomised into treated and control groups. Indirect systolic blood pressure (SBP) was measured under ether anaesthesia. 1,2,3,4-Tetrahydroisoquinoline administered chronically. Blood collected for plasma catecholamine measurement and BP/HR measured at regular intervals. Results: Baseline SBP, HR and body weight comparable between treated and control groups (p=1.00, p=0.20 and p=0.22, respectively). Significant SBP drop seen post PNMTI administration (p=0.02). SBP also showed significant drop in week 1 (p=0.03) and week 2 post treatment (p=0.04). Treated SHR plasma catecholamine and dopamine levels also dropped 2-weeks following the PNMTI administration (p= 0.04). Conclusion: This study is consistent with adrenaline hypothesis in the pathogenesis of essential hypertension in young spontaneously hypertensive rats. Consequently, we have also shown that chronic adrenal medullary inhibition with 1,2,3,4-Tetrahydroisoquinoline will result in sustained BP reduction.
format Article
author Abdullah, Aszrin
Mohd Noor, Noriah
Abdul Razak, Tariq
author_facet Abdullah, Aszrin
Mohd Noor, Noriah
Abdul Razak, Tariq
author_sort Abdullah, Aszrin
title Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats
title_short Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats
title_full Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats
title_fullStr Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats
title_full_unstemmed Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats
title_sort phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats
publisher Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate 2015
url http://irep.iium.edu.my/73868/1/IMJM-Vol-14-Supp-p09-10-Aszrin-Abdullah.pdf
http://irep.iium.edu.my/73868/
http://iiumedic.net/imjm/v1/download/volume_14_supplement/IMJM-Vol-14-Supp-p09-Aszrin-Abdullah.pdf
_version_ 1690370703512043520
score 13.211869

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