Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors
A series of forty-five 1,5-diphenylpenta-2,4-dien-1-one analogues were synthesized and evaluated for their nitric oxide (NO) inhibition activity in IFN-γ/LPS-activated RAW 264.7 cells. Compounds 3h, 7a, 7d and 7e exhibited comparable or significantly higher activity than the standard, curcumin (IC50...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry (RSC)
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/73544/1/Kamal%20Rullah%207.pdf http://irep.iium.edu.my/73544/ https://pubs.rsc.org/en/content/articlelanding/2015/md/c4md00541d#!divAbstract |
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