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Cytomegalovirus impact on elderlies’ vaccination response

Disease burden from the Malaysian elderly population is increasing as demographics shifts towards longer life expectancy. It is increasingly evident that immunosenescence is the central process in many age-related illnesses. Latent human cytomegalovirus (HCMV) infection had been shown to chang...

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Main Authors: Abdull Jalil, Mohd Asyraf, Mohd Yusof, Nazri
Format: Book
Language:English
Published: IIUM Press, International Islamic University Malaysia 2017
Subjects:
QR Microbiology
Online Access:http://irep.iium.edu.my/73540/1/73540_Cytomegalovirus%20impact%20on%20elderlies%E2%80%99.pdf
http://irep.iium.edu.my/73540/
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spelling my.iium.irep.735402019-10-21T06:40:09Z http://irep.iium.edu.my/73540/ Cytomegalovirus impact on elderlies’ vaccination response Abdull Jalil, Mohd Asyraf Mohd Yusof, Nazri QR Microbiology Disease burden from the Malaysian elderly population is increasing as demographics shifts towards longer life expectancy. It is increasingly evident that immunosenescence is the central process in many age-related illnesses. Latent human cytomegalovirus (HCMV) infection had been shown to change the immune system in similar ways to aging, by causing chronic antigenic stress. However, direct evidence on the impact of such changes on health remains contentious due to limited data, variable population backgrounds and individual responses to HCMV. In this study among 59 elderly people in Kuantan, the impact of host HCMV control (measured using HCMV IgG level) on immunosenescence was assessed using Influenza vaccination response via haemagglutination inhibition (HI) assay. A criterion of ≥ fourfold rise in titre and a titre of ≥ 40 was used as an indicator for good response. Effect of chronic co-morbidities and history of significant infection was also studied as contributing factors. It was found that high HCMV IgG levels (> 90 RU/ml) was significantly associated with lower response rate to three vaccine strains (χ2(1) = 6.720, p = 0.010). IIUM Press, International Islamic University Malaysia 2017 Book PeerReviewed application/pdf en http://irep.iium.edu.my/73540/1/73540_Cytomegalovirus%20impact%20on%20elderlies%E2%80%99.pdf Abdull Jalil, Mohd Asyraf and Mohd Yusof, Nazri (2017) Cytomegalovirus impact on elderlies’ vaccination response. IIUM Press, International Islamic University Malaysia, Kuala Lumpur, Malaysia. ISBN 978-967-418-712-5
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QR Microbiology
spellingShingle QR Microbiology
Abdull Jalil, Mohd Asyraf
Mohd Yusof, Nazri
Cytomegalovirus impact on elderlies’ vaccination response
description Disease burden from the Malaysian elderly population is increasing as demographics shifts towards longer life expectancy. It is increasingly evident that immunosenescence is the central process in many age-related illnesses. Latent human cytomegalovirus (HCMV) infection had been shown to change the immune system in similar ways to aging, by causing chronic antigenic stress. However, direct evidence on the impact of such changes on health remains contentious due to limited data, variable population backgrounds and individual responses to HCMV. In this study among 59 elderly people in Kuantan, the impact of host HCMV control (measured using HCMV IgG level) on immunosenescence was assessed using Influenza vaccination response via haemagglutination inhibition (HI) assay. A criterion of ≥ fourfold rise in titre and a titre of ≥ 40 was used as an indicator for good response. Effect of chronic co-morbidities and history of significant infection was also studied as contributing factors. It was found that high HCMV IgG levels (> 90 RU/ml) was significantly associated with lower response rate to three vaccine strains (χ2(1) = 6.720, p = 0.010).
format Book
author Abdull Jalil, Mohd Asyraf
Mohd Yusof, Nazri
author_facet Abdull Jalil, Mohd Asyraf
Mohd Yusof, Nazri
author_sort Abdull Jalil, Mohd Asyraf
title Cytomegalovirus impact on elderlies’ vaccination response
title_short Cytomegalovirus impact on elderlies’ vaccination response
title_full Cytomegalovirus impact on elderlies’ vaccination response
title_fullStr Cytomegalovirus impact on elderlies’ vaccination response
title_full_unstemmed Cytomegalovirus impact on elderlies’ vaccination response
title_sort cytomegalovirus impact on elderlies’ vaccination response
publisher IIUM Press, International Islamic University Malaysia
publishDate 2017
url http://irep.iium.edu.my/73540/1/73540_Cytomegalovirus%20impact%20on%20elderlies%E2%80%99.pdf
http://irep.iium.edu.my/73540/
_version_ 1648739753456041984
score 13.211869

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