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Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization

In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is us...

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Main Authors: MF Sammour, Rana, Bakhtiar, Muhammad Taher, Chatterjee, Bappaditya, Shahiwala, Aliasgar, Mahmood, Syed
Format: Article
Language:English
English
Published: MDPI Basel 2019
Subjects:
RS192 Materia Medica-Pharmaceutical Technology
Online Access:http://irep.iium.edu.my/73453/1/pharmaceutics-11-00350%20%281%29.pdf
http://irep.iium.edu.my/73453/7/73453_Optimization%20of%20aceclofenac%20proniosomes%20by%20using%20different%20carriers%2C%20part%201-%20Development%20and%20characterization_Scopus.pdf
http://irep.iium.edu.my/73453/
https://www.mdpi.com/1999-4923/11/7/350
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spelling my.iium.irep.734532019-11-24T13:39:09Z http://irep.iium.edu.my/73453/ Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization MF Sammour, Rana Bakhtiar, Muhammad Taher Chatterjee, Bappaditya Shahiwala, Aliasgar Mahmood, Syed RS192 Materia Medica-Pharmaceutical Technology In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The present study is intended to develop an optimized proniosomal aceclofenac formula by the use of different carriers. Aceclofenac proniosomes have been prepared by slurry method, and different carriers such as maltodextrin, mannitol, and glucose were tried. Prepared proniosomes characterized by differential scanning calorimetry (DSC) analysis and Fourier transform infrared (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added, powder X-ray diffractometry (XRD) confirmed the amorphous phase of the prepared proniosomes, and finally, the surfactant layer was observed by scanning electron microscopy (SEM). Aceclofenac physical state transformations were confirmed with all formulas but maltodextrin proniosomes exhibited solubility more than other formulations. HPLC method has been used to analyze the niosomes derived from proniosomes in terms of their entrapment capability and drug content. The obtained results revealed that aceclofenac proniosomes can be successfully prepared by using different carriers. MDPI Basel 2019-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/73453/1/pharmaceutics-11-00350%20%281%29.pdf application/pdf en http://irep.iium.edu.my/73453/7/73453_Optimization%20of%20aceclofenac%20proniosomes%20by%20using%20different%20carriers%2C%20part%201-%20Development%20and%20characterization_Scopus.pdf MF Sammour, Rana and Bakhtiar, Muhammad Taher and Chatterjee, Bappaditya and Shahiwala, Aliasgar and Mahmood, Syed (2019) Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization. Pharmaceutics, 11 (7). pp. 1-19. E-ISSN 1999-4923 https://www.mdpi.com/1999-4923/11/7/350 10.3390/pharmaceutics11070350
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RS192 Materia Medica-Pharmaceutical Technology
spellingShingle RS192 Materia Medica-Pharmaceutical Technology
MF Sammour, Rana
Bakhtiar, Muhammad Taher
Chatterjee, Bappaditya
Shahiwala, Aliasgar
Mahmood, Syed
Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
description In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The present study is intended to develop an optimized proniosomal aceclofenac formula by the use of different carriers. Aceclofenac proniosomes have been prepared by slurry method, and different carriers such as maltodextrin, mannitol, and glucose were tried. Prepared proniosomes characterized by differential scanning calorimetry (DSC) analysis and Fourier transform infrared (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added, powder X-ray diffractometry (XRD) confirmed the amorphous phase of the prepared proniosomes, and finally, the surfactant layer was observed by scanning electron microscopy (SEM). Aceclofenac physical state transformations were confirmed with all formulas but maltodextrin proniosomes exhibited solubility more than other formulations. HPLC method has been used to analyze the niosomes derived from proniosomes in terms of their entrapment capability and drug content. The obtained results revealed that aceclofenac proniosomes can be successfully prepared by using different carriers.
format Article
author MF Sammour, Rana
Bakhtiar, Muhammad Taher
Chatterjee, Bappaditya
Shahiwala, Aliasgar
Mahmood, Syed
author_facet MF Sammour, Rana
Bakhtiar, Muhammad Taher
Chatterjee, Bappaditya
Shahiwala, Aliasgar
Mahmood, Syed
author_sort MF Sammour, Rana
title Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_short Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_full Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_fullStr Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_full_unstemmed Optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
title_sort optimization of aceclofenac proniosomes by using different carriers, part 1: development and characterization
publisher MDPI Basel
publishDate 2019
url http://irep.iium.edu.my/73453/1/pharmaceutics-11-00350%20%281%29.pdf
http://irep.iium.edu.my/73453/7/73453_Optimization%20of%20aceclofenac%20proniosomes%20by%20using%20different%20carriers%2C%20part%201-%20Development%20and%20characterization_Scopus.pdf
http://irep.iium.edu.my/73453/
https://www.mdpi.com/1999-4923/11/7/350
_version_ 1651865931850186752
score 13.211869

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