Ameliorative effects of Aquilaria malaccensis leaves aqueous extract on reproductive toxicity induced by cyclophosphamide in male rats
Background: Cyclophosphamide (CP) is a widely used anti-neoplastic and immunosuppressive agent that is associated with adverse side effects including reproductive toxicity. Aquilaria malaccensis (AM) is a traditional medicinal plant which was reported to exhibit high anti-oxidant and free radical...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Penerbit Universiti Sains Malaysia
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/72609/1/72609%20Ameliorative%20Effects.pdf http://irep.iium.edu.my/72609/2/72609%20Ameliorative%20effects%20of%20Aquilaria%20SCOPUS.pdf http://irep.iium.edu.my/72609/13/72609_Ameliorative%20effects%20of%20Aquilaria%20malaccensis_wos.pdf http://irep.iium.edu.my/72609/ http://www.mjms.usm.my/MJMS26012019/04MJMS26012019_OA1.pdf |
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| Summary: | Background: Cyclophosphamide (CP) is a widely used anti-neoplastic and
immunosuppressive agent that is associated with adverse side effects including reproductive
toxicity. Aquilaria malaccensis (AM) is a traditional medicinal plant which was reported to exhibit
high anti-oxidant and free radical scavenging properties. The present study was aimed to evaluate
the protective effects of AM leaves extract on sperm quality following toxic exposure to CP.
Methods: Forty-eight male Sprague Dawley rats were allocated into eight groups of six
rats (n = 6): control, CP only (200 mg kg−1
), AM only (100 mg kg−1
, 300 mg kg−1
and 500 mg kg−1
)
and CP + AM (100 mg kg−1
, 300 mg kg−1
and 500 mg kg−1
). Animals were sacrificed after 63 days of
treatment and the sperm from the caudal epididymis was taken for sperm analysis.
Results: The body and the reproductive organs weight, sperm count and motility did not
differ between CP and other groups (P > 0.05). A significant increase (P < 0.05) in percentage of the
dead and abnormal sperm were seen in the CP alone treated group compared to the control group.
Co-administration of AM to the CP exposed rats significantly reduced the (P < 0.05) percentage of
abnormal sperm as compared to the CP only group.
Conclusion: Overall, the present results represent the potential of AM to protect against
CP induced reproductive toxicity. |
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