Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo
Introduction: Derris trifoliata has been traditionally used as folk for the treatment of , rheumatic joints, diarrhoea, and dysmenorrhea, and rotenoids isolated from the plant have shown to exhibit anti-cancer properties. This study aimed to assess the toxicity effects and antiangiogenic activity of...
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| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English English English English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/69896/3/ISOPS12%20Ankara%20Turkiye%20%20oral%20DrWan%20Azizi%2027.06.2018.pdf http://irep.iium.edu.my/69896/9/ISOPS12-AbstractBook.pdf http://irep.iium.edu.my/69896/10/Acceptance%20Wan%20Mohd%20Azizi%20BIn%20Wan%20Sulaiman-ANTI-ANGIOGENIC%20AND%20TOXICITY%20EFFECTS.pdf http://irep.iium.edu.my/69896/11/Full%20Paper%20DrWan%20Azizi%20ISOPS%20Ankara%20Turkey%20June%202018.pdf http://irep.iium.edu.my/69896/ |
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| Summary: | Introduction: Derris trifoliata has been traditionally used as folk for the treatment of , rheumatic joints, diarrhoea, and dysmenorrhea, and rotenoids isolated from the plant have shown to exhibit anti-cancer properties. This study aimed to assess the toxicity effects and antiangiogenic activity of extract of Derris trifoliata on zebrafish embryo model.
Materials and Methods: Zebrafihs embryos were treated with aqueous extract of Derris Trifoliata to evaluate its effects on angiogenesis and zebrafish-toxicity. Angiogenic response was analyzed using whole-mount alkaline phosphatase (AP) vessel staining on 72 hours post fertilization (hpf) zebrafish embryos.
Results: 1.0 mg/ml concentration was toxic to zebrafish embryos and embryos exposed to concentrations at 0.5 mg/ml and below showed some malformations. Derris trifoliata aqueous extract also showed some anti-angiogenic activity in vivo in the zebrafish embryo model wereby at high concentration inhibited vessel formation in zebrafish embryo.
Conclusions: The anti-angiogenic response of extract of Derris trifoliata in zebrafish in vivo model suggest its therapeutic potential as anti-cancer agent. |
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