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Anticancer activity of acetogenins from Annona muricata fruit

Medicinal plants become very important in our days for their therapeutic benefits to humankind. It sustains human health, and it is commonly known as herbal medicines since ancient times. Annona muricata is a heart-shaped fruit that is consumed raw or as the fruit juice in the tropical area. A. mu...

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Main Authors: Daddiouaissa, Djabir, Amid, Azura
Format: Article
Language:English
English
English
Published: IIUM Press 2018
Subjects:
TP248.13 Biotechnology
Online Access:http://irep.iium.edu.my/68372/8/68372_Anticancer%20activity%20of%20acetogenins%20from%20Annona%20muricata%20fruit_ARTICLE.pdf
http://irep.iium.edu.my/68372/7/68372_Anticancer%20activity%20of%20acetogenins%20from%20Annona%20muricata%20fruit_SCOPUS.pdf
http://irep.iium.edu.my/68372/19/68372%20Anticancer%20Activity%20of%20Acetogenins%20from%20Annona%20Muricata%20Fruit%20WOS.pdf
http://irep.iium.edu.my/68372/
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spelling my.iium.irep.683722019-01-27T07:13:14Z http://irep.iium.edu.my/68372/ Anticancer activity of acetogenins from Annona muricata fruit Daddiouaissa, Djabir Amid, Azura TP248.13 Biotechnology Medicinal plants become very important in our days for their therapeutic benefits to humankind. It sustains human health, and it is commonly known as herbal medicines since ancient times. Annona muricata is a heart-shaped fruit that is consumed raw or as the fruit juice in the tropical area. A. muricata is used in traditional and alternative medicine to treat different ailments such as diabetes, hypertension, respiratory and skin illness, inflammation and cancer. A. muricata contains essential anticancer agents named acetogenins that play the significant role in various cancer types. Acetogenins are strong nicotinamide adenine dinucleotide oxidase inhibitors of the cancer cell's mitochondrial membrane but showed neurotoxic effects in rats. Therefore, acetogenins need to be further investigated to determine the exact mechanisms of action, long-term safety, optimal dosage, and potential side effects. Given the extensive studies on A. muricata, this review focuses on the phytochemistry, medicinal uses, biological activities and the mechanisms of action for the fruit extracts and acetogenins, to stimulate further studies on the fruit pulp used for human consumption. IIUM Press 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68372/8/68372_Anticancer%20activity%20of%20acetogenins%20from%20Annona%20muricata%20fruit_ARTICLE.pdf application/pdf en http://irep.iium.edu.my/68372/7/68372_Anticancer%20activity%20of%20acetogenins%20from%20Annona%20muricata%20fruit_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/68372/19/68372%20Anticancer%20Activity%20of%20Acetogenins%20from%20Annona%20Muricata%20Fruit%20WOS.pdf Daddiouaissa, Djabir and Amid, Azura (2018) Anticancer activity of acetogenins from Annona muricata fruit. International Medical Journal Malaysia, 17 (3). pp. 103-112. ISSN 1823-4631
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic TP248.13 Biotechnology
spellingShingle TP248.13 Biotechnology
Daddiouaissa, Djabir
Amid, Azura
Anticancer activity of acetogenins from Annona muricata fruit
description Medicinal plants become very important in our days for their therapeutic benefits to humankind. It sustains human health, and it is commonly known as herbal medicines since ancient times. Annona muricata is a heart-shaped fruit that is consumed raw or as the fruit juice in the tropical area. A. muricata is used in traditional and alternative medicine to treat different ailments such as diabetes, hypertension, respiratory and skin illness, inflammation and cancer. A. muricata contains essential anticancer agents named acetogenins that play the significant role in various cancer types. Acetogenins are strong nicotinamide adenine dinucleotide oxidase inhibitors of the cancer cell's mitochondrial membrane but showed neurotoxic effects in rats. Therefore, acetogenins need to be further investigated to determine the exact mechanisms of action, long-term safety, optimal dosage, and potential side effects. Given the extensive studies on A. muricata, this review focuses on the phytochemistry, medicinal uses, biological activities and the mechanisms of action for the fruit extracts and acetogenins, to stimulate further studies on the fruit pulp used for human consumption.
format Article
author Daddiouaissa, Djabir
Amid, Azura
author_facet Daddiouaissa, Djabir
Amid, Azura
author_sort Daddiouaissa, Djabir
title Anticancer activity of acetogenins from Annona muricata fruit
title_short Anticancer activity of acetogenins from Annona muricata fruit
title_full Anticancer activity of acetogenins from Annona muricata fruit
title_fullStr Anticancer activity of acetogenins from Annona muricata fruit
title_full_unstemmed Anticancer activity of acetogenins from Annona muricata fruit
title_sort anticancer activity of acetogenins from annona muricata fruit
publisher IIUM Press
publishDate 2018
url http://irep.iium.edu.my/68372/8/68372_Anticancer%20activity%20of%20acetogenins%20from%20Annona%20muricata%20fruit_ARTICLE.pdf
http://irep.iium.edu.my/68372/7/68372_Anticancer%20activity%20of%20acetogenins%20from%20Annona%20muricata%20fruit_SCOPUS.pdf
http://irep.iium.edu.my/68372/19/68372%20Anticancer%20Activity%20of%20Acetogenins%20from%20Annona%20Muricata%20Fruit%20WOS.pdf
http://irep.iium.edu.my/68372/
_version_ 1643619056435068928
score 13.211869

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