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Polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system

During these modern times, numerous types of diseases have been spread and cause death to humanity. One of the diseases that cause a major threat to humanity is cancer. According to the World Health Organization (2017), in 2015, cancer had caused 8.8 million deaths globally. The most lethal which is...

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Main Authors: Abdul Ghani, Radiah, Sahabudin, Adzly Hairee, How, Fiona Ni Foong, Ikmal Hisham, Ahmad Irfan
Format: Monograph
Language:English
Published: 2018
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/67241/1/PROFILE%20FRGS%20RADIAH.pdf
http://irep.iium.edu.my/67241/
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spelling my.iium.irep.672412018-11-30T07:22:02Z http://irep.iium.edu.my/67241/ Polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system Abdul Ghani, Radiah Sahabudin, Adzly Hairee How, Fiona Ni Foong Ikmal Hisham, Ahmad Irfan RB Pathology During these modern times, numerous types of diseases have been spread and cause death to humanity. One of the diseases that cause a major threat to humanity is cancer. According to the World Health Organization (2017), in 2015, cancer had caused 8.8 million deaths globally. The most lethal which is lung cancer (along with trachea and bronchus cancers) had caused 1.7 million deaths which is the 5th most caused death worldwide. Various new methods and drugs on ways to prevent as well as to cure, treat and reduce the effects of cancer have been discovered and researched. However, most of the drugs, artificial and natural, have been known to cause one or several side effects towards the patient while some may cause the cancer patient to undergo painful treatments.Despite most anticancer drugs possess potent cell killing activity in vitro studies; the selective delivery of drugs to cancer cells is thus far becomes a major challenge to oncology. The non-specific actions of drugs on healthy cells cause many restrictions in clinical use due to their systemic toxicity. In response to this matter, specific targeting of anticancer drugs towards cancer cells can be achieved by attaching them to a molecule that is transported into cancer cells via a selective transport system. One strategy to achieve this selective delivery is by exploiting specific transport mechanisms such as the polyamine transport system (PTS). The PTS is an energy-dependent machinery frequently over activated in cancer cells with a high demand for polyamines. Cancer cells differ from healthy cells by the amount of polyamine presents. In cancer cells, the amount of polyamine is higher as it needs more polyamine to grow. By using the PTS, it is hoped that the anti-cancer compound can be transferred to the targeted cells and minimize the harm to healthy cells. 2018 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/67241/1/PROFILE%20FRGS%20RADIAH.pdf Abdul Ghani, Radiah and Sahabudin, Adzly Hairee and How, Fiona Ni Foong and Ikmal Hisham, Ahmad Irfan (2018) Polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system. Project Report. UNSPECIFIED. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RB Pathology
spellingShingle RB Pathology
Abdul Ghani, Radiah
Sahabudin, Adzly Hairee
How, Fiona Ni Foong
Ikmal Hisham, Ahmad Irfan
Polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system
description During these modern times, numerous types of diseases have been spread and cause death to humanity. One of the diseases that cause a major threat to humanity is cancer. According to the World Health Organization (2017), in 2015, cancer had caused 8.8 million deaths globally. The most lethal which is lung cancer (along with trachea and bronchus cancers) had caused 1.7 million deaths which is the 5th most caused death worldwide. Various new methods and drugs on ways to prevent as well as to cure, treat and reduce the effects of cancer have been discovered and researched. However, most of the drugs, artificial and natural, have been known to cause one or several side effects towards the patient while some may cause the cancer patient to undergo painful treatments.Despite most anticancer drugs possess potent cell killing activity in vitro studies; the selective delivery of drugs to cancer cells is thus far becomes a major challenge to oncology. The non-specific actions of drugs on healthy cells cause many restrictions in clinical use due to their systemic toxicity. In response to this matter, specific targeting of anticancer drugs towards cancer cells can be achieved by attaching them to a molecule that is transported into cancer cells via a selective transport system. One strategy to achieve this selective delivery is by exploiting specific transport mechanisms such as the polyamine transport system (PTS). The PTS is an energy-dependent machinery frequently over activated in cancer cells with a high demand for polyamines. Cancer cells differ from healthy cells by the amount of polyamine presents. In cancer cells, the amount of polyamine is higher as it needs more polyamine to grow. By using the PTS, it is hoped that the anti-cancer compound can be transferred to the targeted cells and minimize the harm to healthy cells.
format Monograph
author Abdul Ghani, Radiah
Sahabudin, Adzly Hairee
How, Fiona Ni Foong
Ikmal Hisham, Ahmad Irfan
author_facet Abdul Ghani, Radiah
Sahabudin, Adzly Hairee
How, Fiona Ni Foong
Ikmal Hisham, Ahmad Irfan
author_sort Abdul Ghani, Radiah
title Polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system
title_short Polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system
title_full Polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system
title_fullStr Polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system
title_full_unstemmed Polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system
title_sort polyamine sulfur conjugates: a paradigmn for selective drug delivery to cancer cells via polyamine transport system
publishDate 2018
url http://irep.iium.edu.my/67241/1/PROFILE%20FRGS%20RADIAH.pdf
http://irep.iium.edu.my/67241/
_version_ 1643618169991987200
score 13.211869

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