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Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A

A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The cancer associated LDHA isoform was inhibited with IC...

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Bibliographic Details
Main Authors: Altamimi, Abdul Malek S., Alafeefy, Ahmed Mahmoud, Balode, Agnese, Vozny, Igor V., Pustenko, Aleksandrs, El Shikh, Mohey Eldin M., Alasmary, Fatmah Ali S., Abdel-Gawad, Sherif A., Žalubovskis, Raivis
Format: Article
Language:English
English
Published: Taylor & Francis 2018
Subjects:
QC Physics
Online Access:http://irep.iium.edu.my/65282/1/65282_Symmetric%20molecules%20with%201%2C4-triazole%20moieties%20_article.pdf
http://irep.iium.edu.my/65282/2/65282_Symmetric%20molecules%20with%201%2C4-triazole%20moieties%20_scopus.pdf
http://irep.iium.edu.my/65282/
https://www.tandfonline.com/doi/full/10.1080/14756366.2017.1404593
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http://irep.iium.edu.my/65282/1/65282_Symmetric%20molecules%20with%201%2C4-triazole%20moieties%20_article.pdf
http://irep.iium.edu.my/65282/2/65282_Symmetric%20molecules%20with%201%2C4-triazole%20moieties%20_scopus.pdf
http://irep.iium.edu.my/65282/
https://www.tandfonline.com/doi/full/10.1080/14756366.2017.1404593

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