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Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square

Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscop...

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Main Authors: Saleh, Mohammed S M, Siddiqui, Mohammad Jamshed Ahmad, Mat So'ad, Siti Zaiton, Roheem, Fatimah, Bes-Bes, Salima Saidi, Khatib, Alfi
Format: Article
Language:English
English
English
Published: MDPI 2018
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/64259/7/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20Salak%20%28Salacca%20zalacca%29_article.pdf
http://irep.iium.edu.my/64259/13/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak%20%28salacca%20zalacca%29%20fruit%20extracts%20utilizing%20orthogonal%20partial%20least%20square_WOS.pdf
http://irep.iium.edu.my/64259/18/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak_SCOPUS.pdf
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spelling my.iium.irep.642592019-01-24T02:28:08Z http://irep.iium.edu.my/64259/ Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mat So'ad, Siti Zaiton Roheem, Fatimah Bes-Bes, Salima Saidi Khatib, Alfi QD Chemistry Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscopy (FT-IR) fingerprint, utilizing orthogonal partial least square. This calibration model was applied to develop a rapid analytical method tool for quality control of this fruit. A total of 36 extracts prepared with different solvent ratios of ethanol–water (100, 80, 60, 40.20, 0% v/v) and their α-glucosidase inhibitory activities determined. The FT-IR spectra of ethanol–water extracts measured in the region of 400 and 4000 cm−1 at a resolution of 4 cm−1. Multivariate analysis with a combination of orthogonal partial least-squares (OPLS) algorithm was used to correlate the bioactivity of the samples with the FT-IR spectral data. The OPLS biplot model identified several functional groups (C–H, C=O, C–N, N–H, C–O, and C=C) which actively induced α-glucosidase inhibitory activity. MDPI 2018-06-13 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64259/7/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20Salak%20%28Salacca%20zalacca%29_article.pdf application/pdf en http://irep.iium.edu.my/64259/13/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak%20%28salacca%20zalacca%29%20fruit%20extracts%20utilizing%20orthogonal%20partial%20least%20square_WOS.pdf application/pdf en http://irep.iium.edu.my/64259/18/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak_SCOPUS.pdf Saleh, Mohammed S M and Siddiqui, Mohammad Jamshed Ahmad and Mat So'ad, Siti Zaiton and Roheem, Fatimah and Bes-Bes, Salima Saidi and Khatib, Alfi (2018) Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square. Molecules, 23 (6). pp. 1-10. ISSN 1420-3049 http://www.mdpi.com/1420-3049/23/6/1434/htm 10.3390/molecules23061434
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic QD Chemistry
spellingShingle QD Chemistry
Saleh, Mohammed S M
Siddiqui, Mohammad Jamshed Ahmad
Mat So'ad, Siti Zaiton
Roheem, Fatimah
Bes-Bes, Salima Saidi
Khatib, Alfi
Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
description Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscopy (FT-IR) fingerprint, utilizing orthogonal partial least square. This calibration model was applied to develop a rapid analytical method tool for quality control of this fruit. A total of 36 extracts prepared with different solvent ratios of ethanol–water (100, 80, 60, 40.20, 0% v/v) and their α-glucosidase inhibitory activities determined. The FT-IR spectra of ethanol–water extracts measured in the region of 400 and 4000 cm−1 at a resolution of 4 cm−1. Multivariate analysis with a combination of orthogonal partial least-squares (OPLS) algorithm was used to correlate the bioactivity of the samples with the FT-IR spectral data. The OPLS biplot model identified several functional groups (C–H, C=O, C–N, N–H, C–O, and C=C) which actively induced α-glucosidase inhibitory activity.
format Article
author Saleh, Mohammed S M
Siddiqui, Mohammad Jamshed Ahmad
Mat So'ad, Siti Zaiton
Roheem, Fatimah
Bes-Bes, Salima Saidi
Khatib, Alfi
author_facet Saleh, Mohammed S M
Siddiqui, Mohammad Jamshed Ahmad
Mat So'ad, Siti Zaiton
Roheem, Fatimah
Bes-Bes, Salima Saidi
Khatib, Alfi
author_sort Saleh, Mohammed S M
title Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_short Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_full Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_fullStr Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_full_unstemmed Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_sort correlation of ft-ir fingerprint and α-glucosidase inhibitory activity of salak (salacca zalacca) fruit extracts utilizing orthogonal partial least square
publisher MDPI
publishDate 2018
url http://irep.iium.edu.my/64259/7/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20Salak%20%28Salacca%20zalacca%29_article.pdf
http://irep.iium.edu.my/64259/13/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak%20%28salacca%20zalacca%29%20fruit%20extracts%20utilizing%20orthogonal%20partial%20least%20square_WOS.pdf
http://irep.iium.edu.my/64259/18/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak_SCOPUS.pdf
http://irep.iium.edu.my/64259/
http://www.mdpi.com/1420-3049/23/6/1434/htm
_version_ 1643618804145586176
score 13.211869

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