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Differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease. In the knee OA, several joint changes were observed and among these include articular cartilage (AC) degeneration, and subchondral bone (Sb) remodeling. Despite of extensive experimental and clinical studies, the role of bone remodeling in the two...

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Main Authors: Zamli, Zaitunnatakhin, Talib, Nurul Ain Aisyah, Akman, Akma Azmiera
Format: Monograph
Language:English
Published: 2018
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/63851/2/FINAL%20REPORT%20ENDOWMENT%20B%20%28EDW%20B%2014-207-1092%29.pdf
http://irep.iium.edu.my/63851/
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spelling my.iium.irep.638512020-01-28T03:52:34Z http://irep.iium.edu.my/63851/ Differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis Zamli, Zaitunnatakhin Talib, Nurul Ain Aisyah Akman, Akma Azmiera R Medicine (General) Osteoarthritis (OA) is a degenerative joint disease. In the knee OA, several joint changes were observed and among these include articular cartilage (AC) degeneration, and subchondral bone (Sb) remodeling. Despite of extensive experimental and clinical studies, the role of bone remodeling in the two sub-regions of Sb, i.e. the subchondral bone plate (Sbp) and trabecular bone (Tb), during the initiation and development of OA has yet to be determined. Hence, this study aims to determine the rate of Sbp and Tb remodeling in Dunkin Hartley (DH) guinea pigs at 10, 20 and 30 weeks of age. To achieve this aim, the Sb remodeling parameters and AC degeneration were assessed in the medial and lateral side of the tibia by using histomorphometric and histological techniques, respectively. The data showed that the AC degeneration was more pronounced in the medial than the lateral side, and worsen with ageing. At 30 weeks of age, the percentage of mineralizing surface (MS) of Sbp was higher in the medial than the lateral (medial: 4.17 ± 0 %, lateral: 4.17 ± 0 %). In contrast, the MS, mineral apposition rate (MAR) and bone formation rate (BFR) of Tb was decreased at the final time point and significantly greater in the lateral than the medial side of the tibia. Taken together, the above findings suggest that the decrease of Tb remodeling was due to stress-shielding effects as a result of Sbp thickening and hypermineralization. 2018-05-24 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/63851/2/FINAL%20REPORT%20ENDOWMENT%20B%20%28EDW%20B%2014-207-1092%29.pdf Zamli, Zaitunnatakhin and Talib, Nurul Ain Aisyah and Akman, Akma Azmiera (2018) Differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis. Research Report. UNSPECIFIED. (Unpublished)
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Zamli, Zaitunnatakhin
Talib, Nurul Ain Aisyah
Akman, Akma Azmiera
Differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis
description Osteoarthritis (OA) is a degenerative joint disease. In the knee OA, several joint changes were observed and among these include articular cartilage (AC) degeneration, and subchondral bone (Sb) remodeling. Despite of extensive experimental and clinical studies, the role of bone remodeling in the two sub-regions of Sb, i.e. the subchondral bone plate (Sbp) and trabecular bone (Tb), during the initiation and development of OA has yet to be determined. Hence, this study aims to determine the rate of Sbp and Tb remodeling in Dunkin Hartley (DH) guinea pigs at 10, 20 and 30 weeks of age. To achieve this aim, the Sb remodeling parameters and AC degeneration were assessed in the medial and lateral side of the tibia by using histomorphometric and histological techniques, respectively. The data showed that the AC degeneration was more pronounced in the medial than the lateral side, and worsen with ageing. At 30 weeks of age, the percentage of mineralizing surface (MS) of Sbp was higher in the medial than the lateral (medial: 4.17 ± 0 %, lateral: 4.17 ± 0 %). In contrast, the MS, mineral apposition rate (MAR) and bone formation rate (BFR) of Tb was decreased at the final time point and significantly greater in the lateral than the medial side of the tibia. Taken together, the above findings suggest that the decrease of Tb remodeling was due to stress-shielding effects as a result of Sbp thickening and hypermineralization.
format Monograph
author Zamli, Zaitunnatakhin
Talib, Nurul Ain Aisyah
Akman, Akma Azmiera
author_facet Zamli, Zaitunnatakhin
Talib, Nurul Ain Aisyah
Akman, Akma Azmiera
author_sort Zamli, Zaitunnatakhin
title Differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis
title_short Differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis
title_full Differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis
title_fullStr Differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis
title_full_unstemmed Differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis
title_sort differential remodeling of subchondral bone plate and trabecular bone of the tibia in spontaneous animal models of osteoarthritis
publishDate 2018
url http://irep.iium.edu.my/63851/2/FINAL%20REPORT%20ENDOWMENT%20B%20%28EDW%20B%2014-207-1092%29.pdf
http://irep.iium.edu.my/63851/
_version_ 1657565897948135424
score 13.211869

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