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Prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment

Introduction: The oil extract of black cumin seeds Nigella sativa (NSO) demonstrated considerable preservation of spatial cognitive functions in rats subjected to chronic brain hypoperfusion (CBH). The hippocampal CA1 region pyramidal cells are the earliest neurons suffering neurodegeneration foll...

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Main Authors: Azzubaidi, Marwan Saad, Al-Ani, Imad Matloub Dally, Saxena, Anil Kumar, Faisal, Ghasak Ghazi
Format: Article
Language:English
English
English
Published: Kulliyyah of Medicine, International Islamic University Malaysia 2018
Subjects:
QM Human anatomy
RB Pathology
RM216 Diet Therapy. Clinical Nutrition
Online Access:http://irep.iium.edu.my/63714/7/63714%20Prevention%20of%20brain%20hypoperfusion%20SCOPUS.pdf
http://irep.iium.edu.my/63714/13/63714_Prevention%20of%20brain%20hypoperfusion-induced.pdf
http://irep.iium.edu.my/63714/14/63714_Prevention%20of%20brain%20hypoperfusion-induced_WOS.pdf
http://irep.iium.edu.my/63714/
http://iiumedic.net/imjm/v1/download/volume_17_no_1/Vol17-No1-p103112.pdf
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spelling my.iium.irep.63714 http://irep.iium.edu.my/63714/ Prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment Azzubaidi, Marwan Saad Al-Ani, Imad Matloub Dally Saxena, Anil Kumar Faisal, Ghasak Ghazi QM Human anatomy RB Pathology RM216 Diet Therapy. Clinical Nutrition Introduction: The oil extract of black cumin seeds Nigella sativa (NSO) demonstrated considerable preservation of spatial cognitive functions in rats subjected to chronic brain hypoperfusion (CBH). The hippocampal CA1 region pyramidal cells are the earliest neurons suffering neurodegeneration following CBH. Objective: The current study was devoted to assess the protective effects of Nigella sativa (NSO) treatment on CA1 hippocampal pyramidal cells of rats subjected to chronic brain hypoperfusion (CBH) that was achieved through permanent two vessel occlusion (2VO) procedure. Methods: Twenty four rats were equally divided into three groups; sham control, untreated 2VO and NSO treated group (2VO with daily oral NSO treatment. After the 10th postoperative week coronal sections of the hippocampus were collected for histopathological and electron microscopical examinations. Results: The number of viable pyramidal cells within CA1 hippocampal region in sham control and NSO treated groups was significantly higher than that of untreated 2VO group, while the difference was not significant when comparing the viable pyramidal cells number of sham control with NSO treated groups. Furthermore, 2VO group showed marked intracellular ultrastructural distortions that were less pronounced in NSO treated group. Conclusion: NSO displayed a robust potential to protect hippocampal pyramidal cells from CBH induced neurodegeneration putting forward its prospective neuroprotective activity against age related cognitive decline of Alzheimer’s disease and vascular dementia. Kulliyyah of Medicine, International Islamic University Malaysia 2018-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63714/7/63714%20Prevention%20of%20brain%20hypoperfusion%20SCOPUS.pdf application/pdf en http://irep.iium.edu.my/63714/13/63714_Prevention%20of%20brain%20hypoperfusion-induced.pdf application/pdf en http://irep.iium.edu.my/63714/14/63714_Prevention%20of%20brain%20hypoperfusion-induced_WOS.pdf Azzubaidi, Marwan Saad and Al-Ani, Imad Matloub Dally and Saxena, Anil Kumar and Faisal, Ghasak Ghazi (2018) Prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment. International Medical Journal Malaysia, 17 (1). pp. 103-112. http://iiumedic.net/imjm/v1/download/volume_17_no_1/Vol17-No1-p103112.pdf
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic QM Human anatomy
RB Pathology
RM216 Diet Therapy. Clinical Nutrition
spellingShingle QM Human anatomy
RB Pathology
RM216 Diet Therapy. Clinical Nutrition
Azzubaidi, Marwan Saad
Al-Ani, Imad Matloub Dally
Saxena, Anil Kumar
Faisal, Ghasak Ghazi
Prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment
description Introduction: The oil extract of black cumin seeds Nigella sativa (NSO) demonstrated considerable preservation of spatial cognitive functions in rats subjected to chronic brain hypoperfusion (CBH). The hippocampal CA1 region pyramidal cells are the earliest neurons suffering neurodegeneration following CBH. Objective: The current study was devoted to assess the protective effects of Nigella sativa (NSO) treatment on CA1 hippocampal pyramidal cells of rats subjected to chronic brain hypoperfusion (CBH) that was achieved through permanent two vessel occlusion (2VO) procedure. Methods: Twenty four rats were equally divided into three groups; sham control, untreated 2VO and NSO treated group (2VO with daily oral NSO treatment. After the 10th postoperative week coronal sections of the hippocampus were collected for histopathological and electron microscopical examinations. Results: The number of viable pyramidal cells within CA1 hippocampal region in sham control and NSO treated groups was significantly higher than that of untreated 2VO group, while the difference was not significant when comparing the viable pyramidal cells number of sham control with NSO treated groups. Furthermore, 2VO group showed marked intracellular ultrastructural distortions that were less pronounced in NSO treated group. Conclusion: NSO displayed a robust potential to protect hippocampal pyramidal cells from CBH induced neurodegeneration putting forward its prospective neuroprotective activity against age related cognitive decline of Alzheimer’s disease and vascular dementia.
format Article
author Azzubaidi, Marwan Saad
Al-Ani, Imad Matloub Dally
Saxena, Anil Kumar
Faisal, Ghasak Ghazi
author_facet Azzubaidi, Marwan Saad
Al-Ani, Imad Matloub Dally
Saxena, Anil Kumar
Faisal, Ghasak Ghazi
author_sort Azzubaidi, Marwan Saad
title Prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment
title_short Prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment
title_full Prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment
title_fullStr Prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment
title_full_unstemmed Prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment
title_sort prevention of brain hypoperfusion-induced neurodegeneration in rat’s hippocampus by black cumin fixed oil treatment
publisher Kulliyyah of Medicine, International Islamic University Malaysia
publishDate 2018
url http://irep.iium.edu.my/63714/7/63714%20Prevention%20of%20brain%20hypoperfusion%20SCOPUS.pdf
http://irep.iium.edu.my/63714/13/63714_Prevention%20of%20brain%20hypoperfusion-induced.pdf
http://irep.iium.edu.my/63714/14/63714_Prevention%20of%20brain%20hypoperfusion-induced_WOS.pdf
http://irep.iium.edu.my/63714/
http://iiumedic.net/imjm/v1/download/volume_17_no_1/Vol17-No1-p103112.pdf
_version_ 1643617147093516288
score 13.211869

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