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Prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes.

This study was conducted to compare the outcome in between prostaglandins and oxytocin as methods of induction of labour in prelabour rupture of membranes with unfavorable cervix. This is a prospective randomized double blinded study carried out from 1st July 2012 to 30th June 2013 at Hospital Su...

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Main Authors: Ong, Nabilah, Abu Ishak, Nurkhairulnisa, Raja Ismail, Raja Arif Shah, Awang, Mokhtar, Ismail, Ghazali
Format: Book
Language:English
Published: IIUM Press, International Islamic University Malaysia 2017
Subjects:
RG Gynecology and obstetrics
Online Access:http://irep.iium.edu.my/63087/1/63087_Prostanglandin%20versus%20oxytocin%20for%20induction%20of%20labour%20in%20prelabour%20rupture%20of%20membranes.pdf
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spelling my.iium.irep.630872022-01-07T08:29:53Z http://irep.iium.edu.my/63087/ Prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes. Ong, Nabilah Abu Ishak, Nurkhairulnisa Raja Ismail, Raja Arif Shah Awang, Mokhtar Ismail, Ghazali RG Gynecology and obstetrics This study was conducted to compare the outcome in between prostaglandins and oxytocin as methods of induction of labour in prelabour rupture of membranes with unfavorable cervix. This is a prospective randomized double blinded study carried out from 1st July 2012 to 30th June 2013 at Hospital Sultan Ismail Johor Bahru. A total of 148 women with singleton pregnancies at ≥ 37 weeks, no prior uterine scar, vertex presentation, reactive cardiotocogram (CTG) were randomly assigned to receive immediate induction of labour either by intravenous oxytocin infusion or vaginal prostaglandin E2. The primary outcomes were maternal and neonatal outcome. Data was analyzed using SPSS version 10.0 and p value of <0.05 was considered to be statistically significant. 148 patients were included in this study, 73 patients in prostaglandins arm, and 75 patients in oxytocin arm. The mean age was 27.8+4.9 years old and the mean gestational age was 38.7+1.2 weeks. Majority of them (73%) presented with PROM of less than 24 hours. Following induction of labour, 68% of them achieved vaginal delivery. In the oxytocin group, induction of labour to vaginal delivery interval (7.6+4.7 versus 16.5+14.8, p<0.001) and leaking liquor to delivery interval (19.1+11.8 versus 32.3+22.4, p<0.001) were significantly shorter than the PGE2 group. However caesarean delivery was found 3 times more (32.0% versus 9.6%, p=0.001) in the oxytocin group. The rate of neonatal infections (31.5% versus 8.0%, p<0.001) and NICU admission (38.4% versus 21.3%, p=0.023) were significantly lesser in the oxytocin group. In conclusion, neither oxytocin nor PGE2 was preferred as a method of induction of labour in patients with PROM at term with unfavourable cervix. The management of term PROM therefore needs to be individualized to achieve the best maternal and neonatal outcomes. Expectant management remains as an alternative option. IIUM Press, International Islamic University Malaysia 2017-12-01 Book PeerReviewed application/pdf en http://irep.iium.edu.my/63087/1/63087_Prostanglandin%20versus%20oxytocin%20for%20induction%20of%20labour%20in%20prelabour%20rupture%20of%20membranes.pdf Ong, Nabilah and Abu Ishak, Nurkhairulnisa and Raja Ismail, Raja Arif Shah and Awang, Mokhtar and Ismail, Ghazali (2017) Prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes. IIUM Press, International Islamic University Malaysia, Kuala Lumpur, Malaysia. ISBN 9789674187194
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RG Gynecology and obstetrics
spellingShingle RG Gynecology and obstetrics
Ong, Nabilah
Abu Ishak, Nurkhairulnisa
Raja Ismail, Raja Arif Shah
Awang, Mokhtar
Ismail, Ghazali
Prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes.
description This study was conducted to compare the outcome in between prostaglandins and oxytocin as methods of induction of labour in prelabour rupture of membranes with unfavorable cervix. This is a prospective randomized double blinded study carried out from 1st July 2012 to 30th June 2013 at Hospital Sultan Ismail Johor Bahru. A total of 148 women with singleton pregnancies at ≥ 37 weeks, no prior uterine scar, vertex presentation, reactive cardiotocogram (CTG) were randomly assigned to receive immediate induction of labour either by intravenous oxytocin infusion or vaginal prostaglandin E2. The primary outcomes were maternal and neonatal outcome. Data was analyzed using SPSS version 10.0 and p value of <0.05 was considered to be statistically significant. 148 patients were included in this study, 73 patients in prostaglandins arm, and 75 patients in oxytocin arm. The mean age was 27.8+4.9 years old and the mean gestational age was 38.7+1.2 weeks. Majority of them (73%) presented with PROM of less than 24 hours. Following induction of labour, 68% of them achieved vaginal delivery. In the oxytocin group, induction of labour to vaginal delivery interval (7.6+4.7 versus 16.5+14.8, p<0.001) and leaking liquor to delivery interval (19.1+11.8 versus 32.3+22.4, p<0.001) were significantly shorter than the PGE2 group. However caesarean delivery was found 3 times more (32.0% versus 9.6%, p=0.001) in the oxytocin group. The rate of neonatal infections (31.5% versus 8.0%, p<0.001) and NICU admission (38.4% versus 21.3%, p=0.023) were significantly lesser in the oxytocin group. In conclusion, neither oxytocin nor PGE2 was preferred as a method of induction of labour in patients with PROM at term with unfavourable cervix. The management of term PROM therefore needs to be individualized to achieve the best maternal and neonatal outcomes. Expectant management remains as an alternative option.
format Book
author Ong, Nabilah
Abu Ishak, Nurkhairulnisa
Raja Ismail, Raja Arif Shah
Awang, Mokhtar
Ismail, Ghazali
author_facet Ong, Nabilah
Abu Ishak, Nurkhairulnisa
Raja Ismail, Raja Arif Shah
Awang, Mokhtar
Ismail, Ghazali
author_sort Ong, Nabilah
title Prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes.
title_short Prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes.
title_full Prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes.
title_fullStr Prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes.
title_full_unstemmed Prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes.
title_sort prostanglandin versus oxytocin for induction of labour in prelabour rupture of membranes.
publisher IIUM Press, International Islamic University Malaysia
publishDate 2017
url http://irep.iium.edu.my/63087/1/63087_Prostanglandin%20versus%20oxytocin%20for%20induction%20of%20labour%20in%20prelabour%20rupture%20of%20membranes.pdf
http://irep.iium.edu.my/63087/
_version_ 1724072773659131904
score 13.211869

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