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Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan

Aim: The present study was aimed to highlight the current prescribing pattern of oral hypoglycemia in type 2 diabetes mellitus and to evaluate the therapeutic effectiveness of these therapeutic categories in achieving target glycemic control. Methods: This is a prospective, cross-sectional, observat...

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Main Authors:	Rana, Bareera, Bukhsh, Allah, Khan, Tahir Mehmood, Sarwar, Ammar, Omer, Muhammad Ovais, Jamshed, Shazia Qasim
Format:	Article
Language:	English English English
Published:	Medknow Publications 2017
Subjects:	RC Internal medicine RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/62851/1/62851_Evaluation%20of%20therapeutic%20effectiveness%20of%20prescribed_article.pdf http://irep.iium.edu.my/62851/2/62851_Evaluation%20of%20therapeutic%20effectiveness%20of%20prescribed_scopus.pdf http://irep.iium.edu.my/62851/13/62851_Evaluation%20of%20therapeutic%20effectiveness.pdf http://irep.iium.edu.my/62851/ http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2017;volume=9;issue=2;spage=121;epage=125;aulast=Rana;type=0
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spelling	my.iium.irep.628512018-04-25T02:55:47Z http://irep.iium.edu.my/62851/ Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan Rana, Bareera Bukhsh, Allah Khan, Tahir Mehmood Sarwar, Ammar Omer, Muhammad Ovais Jamshed, Shazia Qasim RC Internal medicine RS Pharmacy and materia medica Aim: The present study was aimed to highlight the current prescribing pattern of oral hypoglycemia in type 2 diabetes mellitus and to evaluate the therapeutic effectiveness of these therapeutic categories in achieving target glycemic control. Methods: This is a prospective, cross-sectional, observational study of 6 months' duration conducted in a tertiary care hospital of Lahore, Pakistan. Results: The current research recruited 145 patients presented in diabetes management center of a tertiary care hospital in Lahore, Pakistan. Mean age of the participants was 50.2 (± 8.5) years. Out of the 145 patients, 63% were females and 37% were males. Most patients were diagnosed to have diabetes within the past 5 years. Diabetes-induced neuropathy was the most common complication (71.7%) among the patients. A large proportion of these patients (70.3%) were also suffering from other comorbidities among which the most common one is hypertension. The average number of prescribed medications was 1.31. Metformin was prescribed to a majority of patients (64%) as monotherapy while 28.96% received combination therapy. Mean glycated hemoglobin (HBA1c) before and after 3 months of treatment was 8.5 (± 2.3) and 8.04 (± 2.1), respectively. Inferential statistics show a strong association between HBA1c and life style modifications and adherence to medication therapy (P = 0.05). However, the correlation between HBA1c and Morisky score and duration of disease was inverse and weak (P = 0.6, 0.4). The t-test values show a small difference between HBA1c values before and after 3 months (t = 0.440 and 0.466, respectively). Conclusion: Optimization of medication regimen and continuous patient education regarding life style modification and adherence to medication therapy are necessitated to bring HBA1c values near to target Medknow Publications 2017-06 Article REM application/pdf en http://irep.iium.edu.my/62851/1/62851_Evaluation%20of%20therapeutic%20effectiveness%20of%20prescribed_article.pdf application/pdf en http://irep.iium.edu.my/62851/2/62851_Evaluation%20of%20therapeutic%20effectiveness%20of%20prescribed_scopus.pdf application/pdf en http://irep.iium.edu.my/62851/13/62851_Evaluation%20of%20therapeutic%20effectiveness.pdf Rana, Bareera and Bukhsh, Allah and Khan, Tahir Mehmood and Sarwar, Ammar and Omer, Muhammad Ovais and Jamshed, Shazia Qasim (2017) Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan. Journal of Pharmacy and Bioallied Sciences, 9 (2 (April-June)). pp. 121-125. ISSN 0976-4879 http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2017;volume=9;issue=2;spage=121;epage=125;aulast=Rana;type=0 10.4103/jpbs.JPBS_29_17
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English English
topic	RC Internal medicine RS Pharmacy and materia medica
spellingShingle	RC Internal medicine RS Pharmacy and materia medica Rana, Bareera Bukhsh, Allah Khan, Tahir Mehmood Sarwar, Ammar Omer, Muhammad Ovais Jamshed, Shazia Qasim Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan
description	Aim: The present study was aimed to highlight the current prescribing pattern of oral hypoglycemia in type 2 diabetes mellitus and to evaluate the therapeutic effectiveness of these therapeutic categories in achieving target glycemic control. Methods: This is a prospective, cross-sectional, observational study of 6 months' duration conducted in a tertiary care hospital of Lahore, Pakistan. Results: The current research recruited 145 patients presented in diabetes management center of a tertiary care hospital in Lahore, Pakistan. Mean age of the participants was 50.2 (± 8.5) years. Out of the 145 patients, 63% were females and 37% were males. Most patients were diagnosed to have diabetes within the past 5 years. Diabetes-induced neuropathy was the most common complication (71.7%) among the patients. A large proportion of these patients (70.3%) were also suffering from other comorbidities among which the most common one is hypertension. The average number of prescribed medications was 1.31. Metformin was prescribed to a majority of patients (64%) as monotherapy while 28.96% received combination therapy. Mean glycated hemoglobin (HBA1c) before and after 3 months of treatment was 8.5 (± 2.3) and 8.04 (± 2.1), respectively. Inferential statistics show a strong association between HBA1c and life style modifications and adherence to medication therapy (P = 0.05). However, the correlation between HBA1c and Morisky score and duration of disease was inverse and weak (P = 0.6, 0.4). The t-test values show a small difference between HBA1c values before and after 3 months (t = 0.440 and 0.466, respectively). Conclusion: Optimization of medication regimen and continuous patient education regarding life style modification and adherence to medication therapy are necessitated to bring HBA1c values near to target
format	Article
author	Rana, Bareera Bukhsh, Allah Khan, Tahir Mehmood Sarwar, Ammar Omer, Muhammad Ovais Jamshed, Shazia Qasim
author_facet	Rana, Bareera Bukhsh, Allah Khan, Tahir Mehmood Sarwar, Ammar Omer, Muhammad Ovais Jamshed, Shazia Qasim
author_sort	Rana, Bareera
title	Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan
title_short	Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan
title_full	Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan
title_fullStr	Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan
title_full_unstemmed	Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan
title_sort	evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, lahore, pakistan
publisher	Medknow Publications
publishDate	2017
url	http://irep.iium.edu.my/62851/1/62851_Evaluation%20of%20therapeutic%20effectiveness%20of%20prescribed_article.pdf http://irep.iium.edu.my/62851/2/62851_Evaluation%20of%20therapeutic%20effectiveness%20of%20prescribed_scopus.pdf http://irep.iium.edu.my/62851/13/62851_Evaluation%20of%20therapeutic%20effectiveness.pdf http://irep.iium.edu.my/62851/ http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2017;volume=9;issue=2;spage=121;epage=125;aulast=Rana;type=0
_version_	1643616253815816192
score	13.223943

Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan

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