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A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines

Researches in compound containing sulphur and the polyamine transport system is beneficial in oncology as both affect cancer cells. Compounds containing sulphur such as organosulphur are known for its anti-cancer properties. Through various experiments by researcher, several new compounds were succe...

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Main Authors: Sahabudin, Adzly Hairee, Abdul Ghani, Radiah, How, Fiona Ni Foong, Halim, Norsuhana, Jamil, Masnizahani
Format: Conference or Workshop Item
Language:English
English
Published: 2017
Subjects:
RM300 Drugs and their action
Online Access:http://irep.iium.edu.my/62787/1/Scan%2027%20Nov%202017%2C%2012.10.pdf
http://irep.iium.edu.my/62787/2/UPM%20poster.pdf
http://irep.iium.edu.my/62787/
http://www.upm.edu.my/activities/fundamental_science_congress_2017_fsc_2017-11199
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spelling my.iium.irep.627872018-04-06T04:08:13Z http://irep.iium.edu.my/62787/ A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines Sahabudin, Adzly Hairee Abdul Ghani, Radiah How, Fiona Ni Foong Halim, Norsuhana Jamil, Masnizahani RM300 Drugs and their action Researches in compound containing sulphur and the polyamine transport system is beneficial in oncology as both affect cancer cells. Compounds containing sulphur such as organosulphur are known for its anti-cancer properties. Through various experiments by researcher, several new compounds were successfully synthesized to combat cancer cells. Some of the compounds that were successfully synthesized were the polyamine-sulphur compounds. By adding sulphur to known natural polyamine, the analogues will be delivered specifically to cancer cells via polyamine transport system (PTS). For the synthesis of the compound, carbon disulphide and benzyl chloride were added to the polyamine (Putrescine or Spermidine) via a method called Room Temperature Mediated Synthesis. The addition of carbon disulphide was to add the sulphur element while the addition of benzyl chloride was to make the compound bulkier and stable. For the addition of carbon disulphide only, the compounds were named PSA-1 and SSA-1 for putrescine and spermidine respectively while for the addition of both carbon disulphide and benzyl chloride were named PSA-2 and SSA-2. The compounds were then analyzed by using Fourier Transformed Infrared Spectroscopy (FTIR) and Gas Chromatography-Mass Spectroscopy (GC-MS) to determine the successful addition of sulphur and benzyl compound. The compounds were then tested with human lung adenocarcinoma cells (A549), human breast adenocarcinoma cell (MCF-7) and human colorectal adenocarcinoma cells (HCT-8). The cytotoxicity effects of these compounds were carried by using MTT assay against these in-vitro cells. The results show the cytotoxic effects were not potent against these cell lines as a higher concentration of compounds were needed to inhibit the cells growth. 2017-11 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/62787/1/Scan%2027%20Nov%202017%2C%2012.10.pdf application/pdf en http://irep.iium.edu.my/62787/2/UPM%20poster.pdf Sahabudin, Adzly Hairee and Abdul Ghani, Radiah and How, Fiona Ni Foong and Halim, Norsuhana and Jamil, Masnizahani (2017) A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines. In: Fundamental Science Congress 2017 (FSC 2017), 21st-22nd Nov. 2017, Serdang, Selangor. (Unpublished) http://www.upm.edu.my/activities/fundamental_science_congress_2017_fsc_2017-11199
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RM300 Drugs and their action
spellingShingle RM300 Drugs and their action
Sahabudin, Adzly Hairee
Abdul Ghani, Radiah
How, Fiona Ni Foong
Halim, Norsuhana
Jamil, Masnizahani
A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines
description Researches in compound containing sulphur and the polyamine transport system is beneficial in oncology as both affect cancer cells. Compounds containing sulphur such as organosulphur are known for its anti-cancer properties. Through various experiments by researcher, several new compounds were successfully synthesized to combat cancer cells. Some of the compounds that were successfully synthesized were the polyamine-sulphur compounds. By adding sulphur to known natural polyamine, the analogues will be delivered specifically to cancer cells via polyamine transport system (PTS). For the synthesis of the compound, carbon disulphide and benzyl chloride were added to the polyamine (Putrescine or Spermidine) via a method called Room Temperature Mediated Synthesis. The addition of carbon disulphide was to add the sulphur element while the addition of benzyl chloride was to make the compound bulkier and stable. For the addition of carbon disulphide only, the compounds were named PSA-1 and SSA-1 for putrescine and spermidine respectively while for the addition of both carbon disulphide and benzyl chloride were named PSA-2 and SSA-2. The compounds were then analyzed by using Fourier Transformed Infrared Spectroscopy (FTIR) and Gas Chromatography-Mass Spectroscopy (GC-MS) to determine the successful addition of sulphur and benzyl compound. The compounds were then tested with human lung adenocarcinoma cells (A549), human breast adenocarcinoma cell (MCF-7) and human colorectal adenocarcinoma cells (HCT-8). The cytotoxicity effects of these compounds were carried by using MTT assay against these in-vitro cells. The results show the cytotoxic effects were not potent against these cell lines as a higher concentration of compounds were needed to inhibit the cells growth.
format Conference or Workshop Item
author Sahabudin, Adzly Hairee
Abdul Ghani, Radiah
How, Fiona Ni Foong
Halim, Norsuhana
Jamil, Masnizahani
author_facet Sahabudin, Adzly Hairee
Abdul Ghani, Radiah
How, Fiona Ni Foong
Halim, Norsuhana
Jamil, Masnizahani
author_sort Sahabudin, Adzly Hairee
title A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines
title_short A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines
title_full A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines
title_fullStr A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines
title_full_unstemmed A review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines
title_sort review on polyamine analogues and its cytotoxic effects against selected human cancer cell lines
publishDate 2017
url http://irep.iium.edu.my/62787/1/Scan%2027%20Nov%202017%2C%2012.10.pdf
http://irep.iium.edu.my/62787/2/UPM%20poster.pdf
http://irep.iium.edu.my/62787/
http://www.upm.edu.my/activities/fundamental_science_congress_2017_fsc_2017-11199
_version_ 1643616239135752192
score 13.211869

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