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Effects of solvents on polymorphism and shape of mefenamic acid crystals

Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, et...

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Main Authors:	Abdul Mudalip, Siti Kholijah, Abu Bakar, Mohd Rushdi, Jamal, Parveen, Adam, Fatmawati, Che Man, Rohaida, Sulaiman, Siti Zubaidah, Mohd Arshad, Zatul Iffah, Md. Shaarani, Shalyda
Format:	Conference or Workshop Item
Language:	English English
Published:	EDP Sciences 2018
Subjects:	T Technology (General) T175 Industrial research. Research and development
Online Access:	http://irep.iium.edu.my/62633/13/62633%20Effects%20of%20Solvents%20on%20Polymorphism%20and%20Shape.pdf http://irep.iium.edu.my/62633/19/62633_Effects%20of%20solvents%20on%20polymorphism%20and%20shape_scopus_new.pdf http://irep.iium.edu.my/62633/ https://www.matec-conferences.org/articles/matecconf/pdf/2018/09/matecconf_mucet2018_02004.pdf
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spelling	my.iium.irep.62633 http://irep.iium.edu.my/62633/ Effects of solvents on polymorphism and shape of mefenamic acid crystals Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Adam, Fatmawati Che Man, Rohaida Sulaiman, Siti Zubaidah Mohd Arshad, Zatul Iffah Md. Shaarani, Shalyda T Technology (General) T175 Industrial research. Research and development Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, ethyl acetate, dimethyl acetamide, dimethyl formamide, and acetone. Natural cooling was employed during the crystallisation process. The crystals produced were dried and analysed using optical microscopy, differential scanning calorimetry, thermal gravimetric analysis, x-ray powder diffraction (XRPD) and fourier transform infrared spectroscopy (FTIR). The analysis confirmed that the crystals obtained using ethyl acetate, ethanol, isopropanol, and acetone are pure Form I with a needle-like flat shape. Meanwhile, the crystallisation using DMF produced polymorphic Form II in cubic shape. EDP Sciences 2018 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/62633/13/62633%20Effects%20of%20Solvents%20on%20Polymorphism%20and%20Shape.pdf application/pdf en http://irep.iium.edu.my/62633/19/62633_Effects%20of%20solvents%20on%20polymorphism%20and%20shape_scopus_new.pdf Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Jamal, Parveen and Adam, Fatmawati and Che Man, Rohaida and Sulaiman, Siti Zubaidah and Mohd Arshad, Zatul Iffah and Md. Shaarani, Shalyda (2018) Effects of solvents on polymorphism and shape of mefenamic acid crystals. In: Malaysia Technical Universities Conference on Engineering and Technology (MUCET 2017)., 6-7 Dec,2017, Penang. https://www.matec-conferences.org/articles/matecconf/pdf/2018/09/matecconf_mucet2018_02004.pdf 10.1051/matecconf/201815002004
institution	Universiti Islam Antarabangsa Malaysia
building	IIUM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	International Islamic University Malaysia
content_source	IIUM Repository (IREP)
url_provider	http://irep.iium.edu.my/
language	English English
topic	T Technology (General) T175 Industrial research. Research and development
spellingShingle	T Technology (General) T175 Industrial research. Research and development Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Adam, Fatmawati Che Man, Rohaida Sulaiman, Siti Zubaidah Mohd Arshad, Zatul Iffah Md. Shaarani, Shalyda Effects of solvents on polymorphism and shape of mefenamic acid crystals
description	Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, ethyl acetate, dimethyl acetamide, dimethyl formamide, and acetone. Natural cooling was employed during the crystallisation process. The crystals produced were dried and analysed using optical microscopy, differential scanning calorimetry, thermal gravimetric analysis, x-ray powder diffraction (XRPD) and fourier transform infrared spectroscopy (FTIR). The analysis confirmed that the crystals obtained using ethyl acetate, ethanol, isopropanol, and acetone are pure Form I with a needle-like flat shape. Meanwhile, the crystallisation using DMF produced polymorphic Form II in cubic shape.
format	Conference or Workshop Item
author	Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Adam, Fatmawati Che Man, Rohaida Sulaiman, Siti Zubaidah Mohd Arshad, Zatul Iffah Md. Shaarani, Shalyda
author_facet	Abdul Mudalip, Siti Kholijah Abu Bakar, Mohd Rushdi Jamal, Parveen Adam, Fatmawati Che Man, Rohaida Sulaiman, Siti Zubaidah Mohd Arshad, Zatul Iffah Md. Shaarani, Shalyda
author_sort	Abdul Mudalip, Siti Kholijah
title	Effects of solvents on polymorphism and shape of mefenamic acid crystals
title_short	Effects of solvents on polymorphism and shape of mefenamic acid crystals
title_full	Effects of solvents on polymorphism and shape of mefenamic acid crystals
title_fullStr	Effects of solvents on polymorphism and shape of mefenamic acid crystals
title_full_unstemmed	Effects of solvents on polymorphism and shape of mefenamic acid crystals
title_sort	effects of solvents on polymorphism and shape of mefenamic acid crystals
publisher	EDP Sciences
publishDate	2018
url	http://irep.iium.edu.my/62633/13/62633%20Effects%20of%20Solvents%20on%20Polymorphism%20and%20Shape.pdf http://irep.iium.edu.my/62633/19/62633_Effects%20of%20solvents%20on%20polymorphism%20and%20shape_scopus_new.pdf http://irep.iium.edu.my/62633/ https://www.matec-conferences.org/articles/matecconf/pdf/2018/09/matecconf_mucet2018_02004.pdf
_version_	1643617081449512960
score	13.211869

Effects of solvents on polymorphism and shape of mefenamic acid crystals

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