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Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting

In this work, the trajectories and capturing of magnetic nanoparticles coated with drug agent are investigated for drug targeting application. Nanoparticles are injected at the entrance of a microvessel and captured by a permanent magnet located at a specified location where tumor exists. The pro...

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Main Authors: Shazri, Syireen, Idres, Moumen
Format: Conference or Workshop Item
Language:English
English
Published: Institute of Physics Publishing 2017
Subjects:
T Technology (General)
Online Access:http://irep.iium.edu.my/62288/1/Shazri_2017_IOP_Conf._Ser.%253A_Mater._Sci._Eng._184_012061.pdf
http://irep.iium.edu.my/62288/7/62288_Numerical%20Investigation%20of%20Magnetic%20Nanoparticles_scopus.pdf
http://irep.iium.edu.my/62288/
http://iopscience.iop.org/article/10.1088/1757-899X/184/1/012061/pdf
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spelling my.iium.irep.62288 http://irep.iium.edu.my/62288/ Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting Shazri, Syireen Idres, Moumen T Technology (General) In this work, the trajectories and capturing of magnetic nanoparticles coated with drug agent are investigated for drug targeting application. Nanoparticles are injected at the entrance of a microvessel and captured by a permanent magnet located at a specified location where tumor exists. The problem is divided into two steps; blood flow solution and nanoparticles trajectory solution. The blood flow in microvessel is obtained both analytically and numerically. Integration of nanoparticles equations of motion to obtain the trajectories is performed using both Matlab and ANSYS Fluent. Discrete Phase Model (DPM) in ANSYS Fluent is used for nanoparticles tracking. The dominant magnetization and drag forces acting on magnetic particles are incorporated to study the trajectories of magnetic particles. Parametric studies for steady flow with single point and multiple point injections are conducted. This includes varying particle diameter and magnet location. Critical minimum diameter for capturing is predicted. Capturing efficiency is reported for all cases. It is found that particle trajectories are strongly dependent on particle size and location of the magnet. The simulation can be used to determine the optimum particle size for treating a tumor, given its size and location. Institute of Physics Publishing 2017-04-03 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/62288/1/Shazri_2017_IOP_Conf._Ser.%253A_Mater._Sci._Eng._184_012061.pdf application/pdf en http://irep.iium.edu.my/62288/7/62288_Numerical%20Investigation%20of%20Magnetic%20Nanoparticles_scopus.pdf Shazri, Syireen and Idres, Moumen (2017) Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting. In: 3rd International Conference on Mechanical, Automotive and Aerospace Engineering 2016 (ICMAAE’16), 25th-27th July 2016, Kuala Lumpur, Malaysia. http://iopscience.iop.org/article/10.1088/1757-899X/184/1/012061/pdf 10.1088/1757-899X/184/1/012061
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic T Technology (General)
spellingShingle T Technology (General)
Shazri, Syireen
Idres, Moumen
Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
description In this work, the trajectories and capturing of magnetic nanoparticles coated with drug agent are investigated for drug targeting application. Nanoparticles are injected at the entrance of a microvessel and captured by a permanent magnet located at a specified location where tumor exists. The problem is divided into two steps; blood flow solution and nanoparticles trajectory solution. The blood flow in microvessel is obtained both analytically and numerically. Integration of nanoparticles equations of motion to obtain the trajectories is performed using both Matlab and ANSYS Fluent. Discrete Phase Model (DPM) in ANSYS Fluent is used for nanoparticles tracking. The dominant magnetization and drag forces acting on magnetic particles are incorporated to study the trajectories of magnetic particles. Parametric studies for steady flow with single point and multiple point injections are conducted. This includes varying particle diameter and magnet location. Critical minimum diameter for capturing is predicted. Capturing efficiency is reported for all cases. It is found that particle trajectories are strongly dependent on particle size and location of the magnet. The simulation can be used to determine the optimum particle size for treating a tumor, given its size and location.
format Conference or Workshop Item
author Shazri, Syireen
Idres, Moumen
author_facet Shazri, Syireen
Idres, Moumen
author_sort Shazri, Syireen
title Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_short Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_full Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_fullStr Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_full_unstemmed Numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
title_sort numerical investigation of magnetic nanoparticles trajectories for magnetic drug targeting
publisher Institute of Physics Publishing
publishDate 2017
url http://irep.iium.edu.my/62288/1/Shazri_2017_IOP_Conf._Ser.%253A_Mater._Sci._Eng._184_012061.pdf
http://irep.iium.edu.my/62288/7/62288_Numerical%20Investigation%20of%20Magnetic%20Nanoparticles_scopus.pdf
http://irep.iium.edu.my/62288/
http://iopscience.iop.org/article/10.1088/1757-899X/184/1/012061/pdf
_version_ 1643617060577607680
score 13.211869

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